HitPredict

Interactor 1: NPM (P06748)
Nucleophosmin (NPM) (Nucleolar phosphoprotein B23) (Nucleolar protein NO38) (Numatrin)
Gene: NPM1

Interactor 2: RFC1 (P35251)
Replication factor C subunit 1 (Activator 1 140 kDa subunit) (A1 140 kDa subunit) (Activator 1 large subunit) (Activator 1 subunit 1) (DNA-binding protein PO-GA) (Replication factor C 140 kDa subunit) (RF-C 140 kDa subunit) (RFC140) (Replication factor C large subunit)
Gene: RFC1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	33961781, 35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006281 - DNA repair GO:0045893 - positive regulation of DNA-templated transcription GO:0140297 - DNA-binding transcription factor binding
Homologous interactions	3

Homologous interactions

Color coding for hit scores

	1 294 Hs			1 1148
+	Hs
		417986 NPM_HUMAN (1-294): 1.47e-143: 407: 100.00		RFC4_HUMAN (557-927): 1.06e-72: 248: 19.47
+	Hs
		418004 NPM_HUMAN (1-294): 1.47e-143: 407: 100.00		RFC5_HUMAN (565-913): 8.86e-65: 225: 19.22
+	Hs
		417987 NPM_HUMAN (1-294): 1.47e-143: 407: 100.00		RFC2_HUMAN (561-915): 3.38e-62: 218: 18.26