HitPredict

Interactor 1: TPM3 (P06753)
Tropomyosin alpha-3 chain (Gamma-tropomyosin) (Tropomyosin-3) (Tropomyosin-5) (hTM5)
Gene: TPM3

Interactor 2: PP1B (P62140)
Serine/threonine-protein phosphatase PP1-beta catalytic subunit (PP-1B) (PPP1CD) (EC 3.1.3.16) (EC 3.1.3.53)
Gene: PPP1CB

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	26496610
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0070062 - extracellular exosome
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 285 Hs			1 327
+	Hs
		451229 TPM1_HUMAN (2-285): 2.54e-44: 153: 91.20		PP1B_HUMAN (1-327): 0: 597: 100.00
+	Dm
		419100 TPM1_DROME (2-282): 8.67e-51: 171: 45.97		PP1B_DROME (1-322): 0: 568: 90.37
+	Hs
		434366 TPM2_HUMAN (2-285): 1.42e-39: 141: 86.27		PP1B_HUMAN (1-327): 0: 597: 100.00
+	Hs
		418899 TPM3_HUMAN (1-285): 3.63e-44: 153: 100.00		PP1G_HUMAN (1-327): 0: 569: 86.89
+	Hs
		906405 TPM4_HUMAN (43-285): 1.76e-33: 124: 69.96		PP1B_HUMAN (1-327): 0: 597: 100.00
+	Dm
		451124 TPM2_DROME (2-284): 6.48e-36: 131: 47.70		PP1B_DROME (1-322): 0: 568: 90.37
+	Hs
		737733 TPM4_HUMAN (43-285): 1.76e-33: 124: 69.96		PP1G_HUMAN (1-327): 0: 569: 86.89
+	Hs
		905955 FKB15_HUMAN (1-284): 5.16e-27: 112: 13.40		PP1A_HUMAN (1-326): 0: 576: 88.79
+	Hs
		110799 H7BYY1_HUMAN (2-228): 1.39e-10: 62.2: 21.37		PP1B_HUMAN (1-327): 0: 597: 100.00
+	Hs
		931058 MRCKB_HUMAN (12-285): 1.02e-11: 67.2: 14.92		PP2AA_HUMAN (8-303): 2.77e-176: 491: 45.79