Protein: AP3B1
AP-3 complex subunit beta-1 (Adaptor protein complex AP-3 subunit beta-1) (Adaptor-related protein complex 3 subunit beta-1) (Beta-3A-adaptin) (Clathrin assembly protein complex 3 beta-1 large chain)

Gene: AP3B1
Organism: Homo sapiens
Interactions: 194
UniProt ID: O00203

Gene Ontology (top 5):
GO:0000902 - cell morphogenesis
GO:0002224 - toll-like receptor signaling pathway
GO:0002244 - hematopoietic progenitor cell differentiation
GO:0003016 - respiratory system process
GO:0005739 - mitochondrion

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

126203

AP3M1
AP-3 complex subunit mu-1

3

20

High-throughput

0.855

High

126078

AP3M2
AP-3 complex subunit mu-2

2

20

High-throughput

0.811

High

126157

AP3S1
AP-3 complex subunit sigma-1

2

20

High-throughput

0.811

High

126022

AP3D1
AP-3 complex subunit delta-1

2

16

Small-scale

0.768

High

126087

ARF6
ADP-ribosylation factor 6

2

20

Small-scale

0.768

High

126093

ARF5
ADP-ribosylation factor 5

2

20

Small-scale

0.768

High

126160

EDA
Ectodysplasin-A

4

2

High-throughput

0.691

High

126165

DTBP1
Dysbindin

3

1

High-throughput

0.667

High

126188

AGO3
Protein argonaute-3

3

2

High-throughput

0.667

High

126028

CREB3
Cyclic AMP-responsive element-binding protein 3

3

3

High-throughput

0.650

High

126092

ARF1
ADP-ribosylation factor 1

1

20

Small-scale

0.647

High

126198

VTI1B
Vesicle transport through interaction with t-SNAREs homolog 1B

3

0

High-throughput

0.638

High

126152

CAMKV
CaM kinase-like vesicle-associated protein

4

1

High-throughput

0.636

High

126021

PESC
Pescadillo homolog

2

1

High-throughput

0.628

High

126123

VASN
Vasorin

2

5

High-throughput

0.628

High

126163

CR3L1
Cyclic AMP-responsive element-binding protein 3-like protein 1

2

3

High-throughput

0.628

High

126083

AP3S2
AP-3 complex subunit sigma-2

1

20

Small-scale

0.618

High

126084

ARF3
ADP-ribosylation factor 3

1

20

High-throughput

0.618

High

126102

AP3B2
AP-3 complex subunit beta-2

1

14

High-throughput

0.618

High

126033

TM63A
Mechanosensitive cation channel TMEM63A

2

0

High-throughput

0.602

High

126079

FGF8
Fibroblast growth factor 8

2

0

High-throughput

0.602

High

126153

TPC2
Two pore channel protein 2

2

0

High-throughput

0.602

High

126172

ERMAP
Erythroid membrane-associated protein

2

0

High-throughput

0.602

High

126150

SYT2
Synaptotagmin-2

2

4

High-throughput

0.601

High

126066

SYUA
Alpha-synuclein

2

3

High-throughput

0.601

High

126029

PRKN
E3 ubiquitin-protein ligase parkin

2

17

High-throughput

0.584

High

126095

HEN2
Helix-loop-helix protein 2

2

0

High-throughput

0.576

High

126025

E41L2
Band 4.1-like protein 2

2

5

High-throughput

0.574

High

126074

PI42A
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha

2

5

High-throughput

0.574

High

126202

E41L3
Band 4.1-like protein 3

2

5

High-throughput

0.574

High

126040

ESR1
Estrogen receptor

2

14

High-throughput

0.571

High

126119

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

2

8

Small-scale

0.571

High

126099

ANK3
Ankyrin-3

1

2

Small-scale

0.552

High

126204

KIF3A
Kinesin-like protein KIF3A

1

5

Small-scale

0.552

High

126137

LRRT4
Leucine-rich repeat transmembrane neuronal protein 4

2

1

High-throughput

0.549

High

126184

E41L1
Band 4.1-like protein 1

2

5

High-throughput

0.549

High

126052

HSP7C
Heat shock cognate 71 kDa protein

1

5

High-throughput

0.536

High

126073

TFPI2
Tissue factor pathway inhibitor 2

1

5

High-throughput

0.536

High

126091

1433Z
14-3-3 protein zeta/delta

1

3

High-throughput

0.536

High

126106

SNW1
SNW domain-containing protein 1

1

2

High-throughput

0.536

High

126121

CR3L3
Cyclic AMP-responsive element-binding protein 3-like protein 3

1

8

High-throughput

0.536

High

126145

FGRL1
Fibroblast growth factor receptor-like 1

1

4

High-throughput

0.536

High

126170

NLRP3
NACHT, LRR and PYD domains-containing protein 3

1

1

High-throughput

0.536

High

126174

SEC62
Translocation protein SEC62

1

2

High-throughput

0.536

High

126190

CHD8
Chromodomain-helicase-DNA-binding protein 8

1

4

High-throughput

0.536

High

126194

PKHJ1
Pleckstrin homology domain-containing family J member 1

1

18

High-throughput

0.536

High

126077

BMX
Cytoplasmic tyrosine-protein kinase BMX

2

7

High-throughput

0.521

High

126101

ATM
Serine-protein kinase ATM

1

5

Small-scale

0.516

High

126058

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

1

High-throughput

0.515

High

126076

ARRB1
Beta-arrestin-1

1

9

High-throughput

0.515

High

126132

ATG9A
Autophagy-related protein 9A

1

6

High-throughput

0.515

High

126069

HD
Huntingtin

1

8

High-throughput

0.515

High

126072

BAG6
Large proline-rich protein BAG6

1

7

High-throughput

0.515

High

126164

OPTN
Optineurin

1

9

High-throughput

0.515

High

126209

RM42
Large ribosomal subunit protein mL42

1

0

High-throughput

0.513

High

126176

ZNT3
Probable proton-coupled zinc antiporter SLC30A3

1

2

Small-scale

0.501

High

126035

DUS14
Dual specificity protein phosphatase 14

1

1

High-throughput

0.489

High

126154

PI42C
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma

1

5

High-throughput

0.489

High

126159

DLG3
Disks large homolog 3

1

3

High-throughput

0.489

High

126191

E41L5
Band 4.1-like protein 5

1

5

High-throughput

0.489

High

126197

IKBL1
NF-kappa-B inhibitor-like protein 1

1

1

High-throughput

0.489

High

126207

WIF1
Wnt inhibitory factor 1

1

1

High-throughput

0.489

High

65922

CC154
Coiled-coil domain-containing protein 154

1

7

High-throughput

0.479

High

126024

XPO1
Exportin-1

1

17

High-throughput

0.479

High

126026

TGON2
Trans-Golgi network integral membrane protein 2

1

12

High-throughput

0.479

High

126037

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

2

High-throughput

0.479

High

126039

AGR2
Anterior gradient protein 2 homolog

1

6

High-throughput

0.479

High

126041

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

5

High-throughput

0.479

High

126042

GCR
Glucocorticoid receptor

1

14

High-throughput

0.479

High

126043

NTRK1
High affinity nerve growth factor receptor

1

14

High-throughput

0.479

High

126044

P53
Cellular tumor antigen p53

1

3

High-throughput

0.479

High

126049

CLCA
Clathrin light chain A

1

14

High-throughput

0.479

High

126050

CLCB
Clathrin light chain B

1

12

High-throughput

0.479

High

126053

LAMP1
Lysosome-associated membrane glycoprotein 1

1

7

High-throughput

0.479

High

126054

RFA2
Replication protein A 32 kDa subunit

1

5

High-throughput

0.479

High

126059

MCM3
DNA replication licensing factor MCM3

1

4

High-throughput

0.479

High

126062

STIP1
Stress-induced-phosphoprotein 1

1

3

High-throughput

0.479

High

126070

PE2R3
Prostaglandin E2 receptor EP3 subtype

1

4

High-throughput

0.479

High

126071

ATRX
Transcriptional regulator ATRX

1

3

High-throughput

0.479

High

126075

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

5

High-throughput

0.479

High

126082

HDAC4
Histone deacetylase 4

1

4

High-throughput

0.479

High

126088

H4
Histone H4

1

2

High-throughput

0.479

High

126097

EP300
Histone acetyltransferase p300

1

15

High-throughput

0.479

High

126103

PLD1
Phospholipase D1

1

2

High-throughput

0.479

High

126104

BIRC3
Baculoviral IAP repeat-containing protein 3

1

2

High-throughput

0.479

High

126107

CUL4A
Cullin-4A

1

6

High-throughput

0.479

High

126113

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

5

High-throughput

0.479

High

126114

KIF14
Kinesin-like protein KIF14

1

10

High-throughput

0.479

High

126115

EEA1
Early endosome antigen 1

1

6

High-throughput

0.479

High

126117

LARP7
La-related protein 7

1

2

High-throughput

0.479

High

126124

LTOR1
Ragulator complex protein LAMTOR1

1

6

High-throughput

0.479

High

126127

LRSM1
E3 ubiquitin-protein ligase LRSAM1

1

1

Small-scale

0.479

High

126130

LMTK1
Serine/threonine-protein kinase LMTK1

1

20

High-throughput

0.479

High

126135

SYVN1
E3 ubiquitin-protein ligase synoviolin

1

2

High-throughput

0.479

High

126147

MINK1
Misshapen-like kinase 1

1

4

High-throughput

0.479

High

126156

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

5

High-throughput

0.479

High

126158

ESR2
Estrogen receptor beta

1

14

High-throughput

0.479

High

126182

WWTR1
WW domain-containing transcription regulator protein 1

1

1

High-throughput

0.479

High

126183

DNJC5
DnaJ homolog subfamily C member 5

1

2

High-throughput

0.479

High

126200

DDX20
Probable ATP-dependent RNA helicase DDX20

1

3

High-throughput

0.479

High

126208

SNX11
Sorting nexin-11

1

6

High-throughput

0.479

High

126063

ARRB2
Beta-arrestin-2

1

9

High-throughput

0.470

High

126120

GKAP1
G kinase-anchoring protein 1

1

0

High-throughput

0.460

High

126032

ENTP6
Ectonucleoside triphosphate diphosphohydrolase 6

1

0

High-throughput

0.458

High

126048

LDHB
L-lactate dehydrogenase B chain

1

0

High-throughput

0.458

High

126055

HMGA1
High mobility group protein HMG-I/HMG-Y

1

0

Small-scale

0.458

High

126061

DPOD1
DNA polymerase delta catalytic subunit

1

0

High-throughput

0.458

High

126081

BID
BH3-interacting domain death agonist

1

0

Small-scale

0.458

High

126116

SEPT7
Septin-7

1

0

Small-scale

0.458

High

126140

FA20C
Extracellular serine/threonine protein kinase FAM20C

1

0

High-throughput

0.458

High

126171

RBM14
RNA-binding protein 14

1

0

High-throughput

0.458

High

126192

PICK1
PRKCA-binding protein

1

0

High-throughput

0.458

High

126027

BUB1
Mitotic checkpoint serine/threonine-protein kinase BUB1

1

10

Small-scale

0.457

High

126046

JUN
Transcription factor Jun

1

8

High-throughput

0.445

High

126057

SYT1
Synaptotagmin-1

1

4

High-throughput

0.445

High

126067

ECHA
Trifunctional enzyme subunit alpha, mitochondrial

1

1

High-throughput

0.445

High

126126

CAVN1
Caveolae-associated protein 1

1

1

High-throughput

0.445

High

60149

HFM1
Probable ATP-dependent DNA helicase HFM1

1

1

High-throughput

0.437

High

104800

APRIO
Alternative prion protein

1

6

High-throughput

0.437

High

126038

M4K4
Mitogen-activated protein kinase kinase kinase kinase 4

1

9

High-throughput

0.437

High

126045

H2A1B
Histone H2A type 1-B/E

1

1

High-throughput

0.437

High

126056

VGFR1
Vascular endothelial growth factor receptor 1

1

3

High-throughput

0.437

High

126060

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

5

High-throughput

0.437

High

126064

GRK5
G protein-coupled receptor kinase 5

1

4

High-throughput

0.437

High

126065

RFA3
Replication protein A 14 kDa subunit

1

5

High-throughput

0.437

High

126068

CCNF
Cyclin-F

1

3

High-throughput

0.437

High

126080

MFAP1
Microfibrillar-associated protein 1

1

6

High-throughput

0.437

High

126085

RPAB2
DNA-directed RNA polymerases I, II, and III subunit RPABC2

1

1

High-throughput

0.437

High

126086

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

3

High-throughput

0.437

High

126094

VIGLN
Vigilin

1

5

High-throughput

0.437

High

126098

M4K2
Mitogen-activated protein kinase kinase kinase kinase 2

1

5

High-throughput

0.437

High

126100

TIF1B
Transcription intermediary factor 1-beta

1

3

High-throughput

0.437

High

126108

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

5

High-throughput

0.437

High

126109

TRI25
E3 ubiquitin/ISG15 ligase TRIM25

1

1

High-throughput

0.437

High

126112

NOLC1
Nucleolar and coiled-body phosphoprotein 1

1

7

High-throughput

0.437

High

126118

DUS28
Dual specificity phosphatase 28

1

1

High-throughput

0.437

High

126122

VIR
Protein virilizer homolog

1

2

High-throughput

0.437

High

126125

STYK1
Tyrosine-protein kinase STYK1

1

9

High-throughput

0.437

High

126128

LMBRL
Protein LMBR1L

1

3

High-throughput

0.437

High

126129

TPTE2
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2

1

7

High-throughput

0.437

High

126131

TRI67
Tripartite motif-containing protein 67

1

6

High-throughput

0.437

High

126133

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

3

High-throughput

0.437

High

126141

SLX4
Structure-specific endonuclease subunit SLX4

1

10

High-throughput

0.437

High

126143

RHG24
Rho GTPase-activating protein 24

1

5

High-throughput

0.437

High

126149

CGAS
Cyclic GMP-AMP synthase

1

1

High-throughput

0.437

High

126155

ZNRF4
E3 ubiquitin-protein ligase ZNRF4

1

8

High-throughput

0.437

High

126161

FBX32
F-box only protein 32

1

1

High-throughput

0.437

High

126178

E2AK1
Eukaryotic translation initiation factor 2-alpha kinase 1

1

7

High-throughput

0.437

High

126180

YTHD1
YTH domain-containing family protein 1

1

7

High-throughput

0.437

High

126185

PKHA4
Pleckstrin homology domain-containing family A member 4

1

20

High-throughput

0.437

High

126186

BRD9
Bromodomain-containing protein 9

1

13

High-throughput

0.437

High

126187

WDR76
WD repeat-containing protein 76

1

5

High-throughput

0.437

High

126189

CPAP
Centrosomal P4.1-associated protein

1

4

High-throughput

0.437

High

126195

TLS1
Splicing factor C9orf78

1

5

High-throughput

0.437

High

126199

ZRAN1
Ubiquitin thioesterase ZRANB1

1

2

High-throughput

0.437

High

126201

FBW1A
F-box/WD repeat-containing protein 1A

1

5

High-throughput

0.437

High

126206

YTHD2
YTH domain-containing family protein 2

1

7

High-throughput

0.437

High

62409

S35F4
Solute carrier family 35 member F4

1

0

High-throughput

0.426

High

126089

RS24
Small ribosomal subunit protein eS24

1

0

High-throughput

0.426

High

126173

DIRC2
Solute carrier family 49 member 4

1

0

High-throughput

0.426

High

126177

MICU1
Calcium uptake protein 1, mitochondrial

1

0

High-throughput

0.426

High

126030

BUB1B
Mitotic checkpoint serine/threonine-protein kinase BUB1 beta

1

11

Small-scale

0.417

High

126105

ATR
Serine/threonine-protein kinase ATR

1

5

Small-scale

0.408

High

126031

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

4

High-throughput

0.407

High

126036

PTBP3
Polypyrimidine tract-binding protein 3

1

1

High-throughput

0.407

High

126096

BTK
Tyrosine-protein kinase BTK

1

7

High-throughput

0.407

High

126138

IQGA3
Ras GTPase-activating-like protein IQGAP3

1

4

High-throughput

0.407

High

126162

PBIP1
Pre-B-cell leukemia transcription factor-interacting protein 1

1

2

High-throughput

0.407

High

126168

FRMD6
FERM domain-containing protein 6

1

6

High-throughput

0.407

High

126142

FAM9A
Protein FAM9A

3

0

High-throughput

0.347

High

126034

KDM4B
Lysine-specific demethylase 4B

1

0

High-throughput

0.279

Low

126110

FGFP1
Fibroblast growth factor-binding protein 1

1

0

High-throughput

0.279

Low

126111

ZN460
Zinc finger protein 460

1

0

High-throughput

0.279

Low

126136

PNM8A
Paraneoplastic antigen-like protein 8A

1

0

High-throughput

0.279

Low

126139

SKA3
Spindle and kinetochore-associated protein 3

1

0

High-throughput

0.279

Low

126144

PLCD3
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3

1

0

High-throughput

0.279

Low

126146

RYBP
RING1 and YY1-binding protein

1

0

High-throughput

0.279

Low

126179

UTP23
rRNA-processing protein UTP23 homolog

1

0

High-throughput

0.279

Low

126047

K2C8
Keratin, type II cytoskeletal 8

1

0

High-throughput

0.269

Low

3490

A0A0S2Z5Q7
Alsin Rho guanine nucleotide exchange factor ALS2

1

0

High-throughput

0.268

Low

126023

IDLC
Axonemal dynein light intermediate polypeptide 1

1

0

High-throughput

0.268

Low

126090

RS25
Small ribosomal subunit protein eS25

1

0

High-throughput

0.249

Low

126134

SLN11
Schlafen family member 11

1

0

Small-scale

0.249

Low

126148

CCD33
Coiled-coil domain-containing protein 33

1

0

High-throughput

0.249

Low

126151

PR38A
Pre-mRNA-splicing factor 38A

1

0

High-throughput

0.249

Low

126166

NAF1
H/ACA ribonucleoprotein complex non-core subunit NAF1

1

0

High-throughput

0.249

Low

126167

EAF1
ELL-associated factor 1

1

0

High-throughput

0.249

Low

126169

BROMI
Protein broad-minded

1

0

Small-scale

0.249

Low

126175

CTIP
DNA endonuclease RBBP8

1

0

Small-scale

0.249

Low

126181

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

0

High-throughput

0.249

Low

126193

RAD18
E3 ubiquitin-protein ligase RAD18

1

0

High-throughput

0.249

Low

126196

PD1L1
Programmed cell death 1 ligand 1

1

0

Small-scale

0.249

Low

126051

CT456
Cancer/testis antigen family 45 member A6

1

0

High-throughput

0.232

Low

126205

INSL6
Insulin-like peptide INSL6

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025