HitPredict

Interactor 1: TPM3 (P06753)
Tropomyosin alpha-3 chain (Gamma-tropomyosin) (Tropomyosin-3) (Tropomyosin-5) (hTM5)
Gene: TPM3

Interactor 2: BRE1A (Q5VTR2)
E3 ubiquitin-protein ligase BRE1A (BRE1-A) (hBRE1) (EC 2.3.2.27) (RING finger protein 20) (RING-type E3 ubiquitin transferase BRE1A)
Gene: RNF20

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.50	0.437

Property	Details
Experiments	27557628
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 285 Hs			1 975
+	Hs
		256241 TPM4_HUMAN (43-285): 1.76e-33: 124: 69.96		BRE1B_HUMAN (1-974): 4.61e-62: 230: 56.49
+	Hs
		418895 TPM3_HUMAN (1-285): 3.63e-44: 153: 100.00		MYH9_HUMAN (235-957): 1.06e-32: 139: 11.26
+	Hs
		451201 TPM1_HUMAN (2-285): 2.54e-44: 153: 91.20		MYH9_HUMAN (235-957): 1.06e-32: 139: 11.26
+	Hs
		434354 TPM2_HUMAN (2-285): 1.42e-39: 141: 86.27		MYH9_HUMAN (235-957): 1.06e-32: 139: 11.26
+	Hs
		724765 TPM4_HUMAN (43-285): 1.76e-33: 124: 69.96		MYH9_HUMAN (235-957): 1.06e-32: 139: 11.26
+	Dm
		404216 TPM2_DROME (2-284): 6.48e-36: 131: 47.70		MYSA_DROME (2-829): 3.47e-29: 128: 10.76
+	Hs
		148289 TPM3_HUMAN (1-285): 3.63e-44: 153: 100.00		CTRO_HUMAN (49-890): 9.97e-15: 81.5: 14.94
+	Hs
		419011 TPM3_HUMAN (1-285): 3.63e-44: 153: 100.00		MY18A_HUMAN (326-919): 1.43e-10: 67.7: 15.69
+	Hs
		451293 TPM1_HUMAN (2-285): 2.54e-44: 153: 91.20		MY18A_HUMAN (326-919): 1.43e-10: 67.7: 15.69
+	Hs
		434415 TPM2_HUMAN (2-285): 1.42e-39: 141: 86.27		MY18A_HUMAN (326-919): 1.43e-10: 67.7: 15.69
+	Hs
		148661 TPM4_HUMAN (43-285): 1.76e-33: 124: 69.96		CTRO_HUMAN (49-890): 9.97e-15: 81.5: 14.94
+	Hs
		110796 H7BYY1_HUMAN (2-228): 1.39e-10: 62.2: 21.37		MYH9_HUMAN (235-957): 1.06e-32: 139: 11.26
+	Hs
		932031 TPM4_HUMAN (43-285): 1.76e-33: 124: 69.96		MY18A_HUMAN (326-919): 1.43e-10: 67.7: 15.69
+	Hs
		1268126 MRCKB_HUMAN (12-285): 1.02e-11: 67.2: 14.92		MY18A_HUMAN (326-919): 1.43e-10: 67.7: 15.69
+	Hs
		110802 H7BYY1_HUMAN (2-228): 1.39e-10: 62.2: 21.37		MY18A_HUMAN (326-919): 1.43e-10: 67.7: 15.69