HitPredict

Interactor 1: TOP2 (P06786)
DNA topoisomerase 2 (EC 5.6.2.2) (DNA topoisomerase II)
Gene: TOP2

Interactor 2: BDF2 (Q07442)
Bromodomain-containing factor 2
Gene: BDF2

Species: Saccharomyces cerevisiae S288C

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	37968396
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 1428 Sc			1 638
+	Sc
		420112 TOP2_YEAST (1-1428): 0: 1426: 100.00		BDF1_YEAST (60-631): 1.57e-89: 294: 36.20
+	Sp
		435853 TOP2_SCHPO (11-1414): 0: 1365: 47.86		YK82_SCHPO (4-626): 1.53e-99: 321: 21.67
+	Hs
		509005 TOP2A_HUMAN (2-1427): 0: 1480: 41.18		BRD3_HUMAN (296-491): 2.95e-27: 119: 20.41
+	Hs
		243848 TOP2A_HUMAN (2-1427): 0: 1480: 41.18		BRD4_HUMAN (278-457): 1.37e-25: 114: 22.22
+	Hs
		973337 TOP2B_HUMAN (2-1420): 0: 1475: 40.55		BRD3_HUMAN (296-491): 2.95e-27: 119: 20.41
+	Hs
		508826 TOP2A_HUMAN (2-1427): 0: 1480: 41.18		BRD2_HUMAN (445-637): 1.38e-24: 111: 14.21
+	Hs
		244311 TOP2B_HUMAN (2-1420): 0: 1475: 40.55		BRD4_HUMAN (278-457): 1.37e-25: 114: 22.22
+	Hs
		631406 TOP2B_HUMAN (2-1420): 0: 1475: 40.55		BRD2_HUMAN (445-637): 1.38e-24: 111: 14.21
+	Mm
		964613 TOP2A_MOUSE (3-1427): 0: 1488: 40.97		PB1_MOUSE (41-329): 1.08e-19: 96.3: 14.14
+	Hs
		509044 TOP2A_HUMAN (2-1427): 0: 1480: 41.18		PB1_HUMAN (65-329): 8.02e-20: 96.7: 12.41
+	Hs
		508967 TOP2A_HUMAN (2-1427): 0: 1480: 41.18		EP300_HUMAN (342-419): 4.06e-12: 72: 44.87
+	Hs
		973319 TOP2B_HUMAN (2-1420): 0: 1475: 40.55		EP300_HUMAN (342-419): 4.06e-12: 72: 44.87
+	Sc
		728775 MDN1_YEAST (838-1427): 3.39e-52: 205: 10.77		BDF1_YEAST (60-631): 1.57e-89: 294: 36.20
+	Hs
		631467 CAPR2_HUMAN (905-1423): 9.32e-40: 163: 12.10		BRD2_HUMAN (445-637): 1.38e-24: 111: 14.21