HitPredict

Interactor 1: TNFA (P06804)
Tumor necrosis factor (Cachectin) (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) [Cleaved into: Tumor necrosis factor, membrane form (N-terminal fragment) (NTF); Intracellular domain 1 (ICD1); Intracellular domain 2 (ICD2); C-domain 1; C-domain 2; Tumor necrosis factor, soluble form]
Gene: Tnf

Interactor 2: TNR1A (P25118)
Tumor necrosis factor receptor superfamily member 1A (Tumor necrosis factor receptor 1) (TNF-R1) (Tumor necrosis factor receptor type I) (TNF-RI) (TNFR-I) (p55) (p60) (CD antigen CD120a)
Gene: Tnfrsf1a

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.91 1.00 0.957

The method score is based on:

Property Details
Experiments 11448951, 29891719, 29203883, 30420664, 18621737, 24469399, 18022363
Identification Methods pull down, affinity chromatography technology, surface plasmon resonance, anti bait coimmunoprecipitation
Interaction Type direct interaction, physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains TNF~TNFR_c6
Common GO terms GO:0002020 - protease binding
GO:0005615 - extracellular space
GO:0005886 - plasma membrane
GO:0006952 - defense response
GO:0006954 - inflammatory response
and 19 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 235
Mm

1 454
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024