HitPredict

Interactor 1: TNFA (P06804)
Tumor necrosis factor (Cachectin) (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) [Cleaved into: Tumor necrosis factor, membrane form (N-terminal fragment) (NTF); Intracellular domain 1 (ICD1); Intracellular domain 2 (ICD2); C-domain 1; C-domain 2; Tumor necrosis factor, soluble form]
Gene: Tnf

Interactor 2: RIPK1 (Q60855)
Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Cell death protein RIP) (Receptor-interacting protein 1) (RIP-1)
Gene: RIPK1

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.87 0.60 0.723

The method score is based on:

Property Details
Experiments 29891719, 29203883, 30420664, 18621737, 19955178, 24469399
Identification Methods affinity chromatography technology, pull down
Interaction Type physical association, direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0001934 - positive regulation of protein phosphorylation
GO:0006954 - inflammatory response
GO:0008625 - extrinsic apoptotic signaling pathway via death domain receptors
GO:0032757 - positive regulation of interleukin-8 production
GO:0033209 - tumor necrosis factor-mediated signaling pathway
and 12 others

more...
Homologous interactions 14

Homologous interactions

Color coding for hit scores

1 235
Mm

1 656
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024