Protein: K2C1
Keratin, type II cytoskeletal 1 (67 kDa cytokeratin) (Cytokeratin-1) (CK-1) (Hair alpha protein) (Keratin-1) (K1) (Type-II keratin Kb1)

Gene: K2C1, KRT1
Organism: Homo sapiens
Interactions: 225
UniProt ID: P04264

Gene Ontology (top 5):
GO:0001533 - cornified envelope
GO:0001867 - complement activation, lectin pathway
GO:0005576 - extracellular region
GO:0005615 - extracellular space
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

380554

K1C15
Keratin, type I cytoskeletal 15

3

20

High-throughput

0.875

High

380611

KT33B
Keratin, type I cuticular Ha3-II

3

20

High-throughput

0.875

High

280507

KRT34
Keratin, type I cuticular Ha4

2

20

High-throughput

0.783

High

280768

KRT36
Keratin, type I cuticular Ha6

2

20

High-throughput

0.783

High

280844

KRT37
Keratin, type I cuticular Ha7

2

20

High-throughput

0.783

High

280942

KRT38
Keratin, type I cuticular Ha8

2

20

High-throughput

0.783

High

359288

K1C14
Keratin, type I cytoskeletal 14

2

20

High-throughput

0.783

High

380538

K1C19
Keratin, type I cytoskeletal 19

2

20

High-throughput

0.783

High

380539

K1C16
Keratin, type I cytoskeletal 16

2

20

High-throughput

0.783

High

380549

K1C13
Keratin, type I cytoskeletal 13

2

20

High-throughput

0.783

High

380618

K1H1
Keratin, type I cuticular Ha1

2

20

High-throughput

0.783

High

380624

K1C24
Keratin, type I cytoskeletal 24

2

20

High-throughput

0.783

High

380632

K1C39
Keratin, type I cytoskeletal 39

2

20

High-throughput

0.783

High

380645

K1C28
Keratin, type I cytoskeletal 28

2

20

High-throughput

0.783

High

380646

K1C27
Keratin, type I cytoskeletal 27

2

20

High-throughput

0.783

High

380647

K1C26
Keratin, type I cytoskeletal 26

2

20

High-throughput

0.783

High

380648

K1C25
Keratin, type I cytoskeletal 25

2

20

High-throughput

0.783

High

380657

KRT35
Keratin, type I cuticular Ha5

2

20

High-throughput

0.783

High

380548

K1C10
Keratin, type I cytoskeletal 10

1

20

Small-scale

0.761

High

380573

NUP62
Nuclear pore glycoprotein p62

3

5

High-throughput

0.664

High

380631

K1C40
Keratin, type I cytoskeletal 40

1

20

High-throughput

0.621

High

380534

K2C8
Keratin, type II cytoskeletal 8

1

20

High-throughput

0.618

High

380550

GFAP
Glial fibrillary acidic protein

1

20

High-throughput

0.618

High

380597

K1C17
Keratin, type I cytoskeletal 17

1

20

High-throughput

0.618

High

380606

CUL3
Cullin-3

2

20

High-throughput

0.611

High

380608

CUL4B
Cullin-4B

2

20

Small-scale

0.611

High

380665

HAUS1
HAUS augmin-like complex subunit 1

2

1

High-throughput

0.606

High

380667

HOOK2
Protein Hook homolog 2

2

8

High-throughput

0.606

High

380669

SGTB
Small glutamine-rich tetratricopeptide repeat-containing protein beta

2

4

High-throughput

0.606

High

380681

TRI54
Tripartite motif-containing protein 54

2

20

High-throughput

0.606

High

380695

HM20A
High mobility group protein 20A

2

4

High-throughput

0.606

High

380699

TFP11
Tuftelin-interacting protein 11

2

4

High-throughput

0.606

High

380706

AMOL2
Angiomotin-like protein 2

2

12

High-throughput

0.606

High

380600

GOGA2
Golgin subfamily A member 2

3

7

High-throughput

0.603

High

380555

VCAM1
Vascular cell adhesion protein 1

2

4

High-throughput

0.601

High

380691

MLP3A
Microtubule-associated proteins 1A/1B light chain 3A

2

20

High-throughput

0.585

High

380560

CBL
E3 ubiquitin-protein ligase CBL

2

10

High-throughput

0.584

High

380626

LARP7
La-related protein 7

2

10

High-throughput

0.584

High

380633

RINT1
RAD50-interacting protein 1

2

0

High-throughput

0.580

High

380674

TLCD4
TLC domain-containing protein 4

2

0

High-throughput

0.580

High

337744

EGFR
Epidermal growth factor receptor

2

6

Small-scale

0.571

High

62264

GG6L9
Golgin subfamily A member 6-like protein 9

2

13

High-throughput

0.553

High

183215

FFAR2
Free fatty acid receptor 2

2

2

High-throughput

0.553

High

380595

U2AF1
Splicing factor U2AF 35 kDa subunit

2

1

High-throughput

0.553

High

362667

FINC
Fibronectin

1

5

High-throughput

0.536

High

363681

ALBU
Albumin

1

3

High-throughput

0.536

High

380574

IF4A3
Eukaryotic initiation factor 4A-III

1

10

High-throughput

0.536

High

380604

CUL1
Cullin-1

1

20

High-throughput

0.536

High

380605

CUL2
Cullin-2

1

20

High-throughput

0.536

High

380607

CUL4A
Cullin-4A

1

20

High-throughput

0.536

High

380613

FL2D
Pre-mRNA-splicing regulator WTAP

1

6

High-throughput

0.536

High

380621

NEDD8
NEDD8

1

3

High-throughput

0.536

High

380644

CSN6
COP9 signalosome complex subunit 6

1

9

High-throughput

0.536

High

380649

MTA70
N6-adenosine-methyltransferase catalytic subunit

1

13

High-throughput

0.536

High

380650

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

5

High-throughput

0.536

High

380660

CSN5
COP9 signalosome complex subunit 5

1

15

High-throughput

0.536

High

380662

CUL5
Cullin-5

1

20

High-throughput

0.536

High

380670

DCNL1
DCN1-like protein 1

1

3

High-throughput

0.536

High

380694

MET14
N6-adenosine-methyltransferase non-catalytic subunit

1

13

High-throughput

0.536

High

380552

TRI27
Zinc finger protein RFP

1

7

High-throughput

0.529

High

380553

DESP
Desmoplakin

1

20

Small-scale

0.527

High

380545

CADH1
Cadherin-1

1

1

Small-scale

0.515

High

380563

1433T
14-3-3 protein theta

1

20

High-throughput

0.515

High

380564

DPP4
Dipeptidyl peptidase 4

1

1

High-throughput

0.515

High

380617

PCM1
Pericentriolar material 1 protein

1

4

High-throughput

0.515

High

361294

APOA1
Apolipoprotein A-I

1

0

High-throughput

0.513

High

174537

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

1

High-throughput

0.501

High

380536

INVO
Involucrin

1

2

Small-scale

0.501

High

380598

UBE3A
Ubiquitin-protein ligase E3A

1

4

Small-scale

0.501

High

380593

2ABB
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

1

6

High-throughput

0.484

High

380619

T22D1
TSC22 domain family protein 1

1

1

Small-scale

0.484

High

380705

NINL
Ninein-like protein

1

12

High-throughput

0.481

High

345036

CYTA
Cystatin-A

1

0

Small-scale

0.480

High

345165

KNG1
Kininogen-1

1

0

Small-scale

0.480

High

380556

ELAF
Elafin

1

0

Small-scale

0.480

High

380561

LORI
Loricrin

1

0

Small-scale

0.480

High

124718

EIF3F
Eukaryotic translation initiation factor 3 subunit F

1

9

Small-scale

0.479

High

129157

P85B
Phosphatidylinositol 3-kinase regulatory subunit beta

1

18

High-throughput

0.479

High

133832

DDX3X
ATP-dependent RNA helicase DDX3X

1

5

Small-scale

0.479

High

150813

DVL2
Segment polarity protein dishevelled homolog DVL-2

1

4

High-throughput

0.479

High

152996

IMPA2
Inositol monophosphatase 2

1

1

High-throughput

0.479

High

176339

SHIP2
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2

1

7

High-throughput

0.479

High

197182

SERA
D-3-phosphoglycerate dehydrogenase

1

4

Small-scale

0.479

High

226232

PRKN
E3 ubiquitin-protein ligase parkin

1

11

High-throughput

0.479

High

241931

PAGE4
P antigen family member 4

1

1

High-throughput

0.479

High

260453

PITX3
Pituitary homeobox 3

1

3

Small-scale

0.479

High

267839

EED
Polycomb protein EED

1

9

High-throughput

0.479

High

282466

RNF8
E3 ubiquitin-protein ligase RNF8

1

12

High-throughput

0.479

High

298040

UFL1
E3 UFM1-protein ligase 1

1

1

High-throughput

0.479

High

301526

TRI37
E3 ubiquitin-protein ligase TRIM37

1

20

High-throughput

0.479

High

302768

HEXI1
Protein HEXIM1

1

16

High-throughput

0.479

High

312440

ARI2
E3 ubiquitin-protein ligase ARIH2

1

14

High-throughput

0.479

High

345661

MYC
Myc proto-oncogene protein

1

12

High-throughput

0.479

High

352431

TNFA
Tumor necrosis factor

1

4

High-throughput

0.479

High

368794

ESR1
Estrogen receptor

1

13

Small-scale

0.479

High

373488

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

6

High-throughput

0.479

High

378892

MYCN
N-myc proto-oncogene protein

1

12

High-throughput

0.479

High

380227

HG2A
HLA class II histocompatibility antigen gamma chain

1

3

High-throughput

0.479

High

380533

P53
Cellular tumor antigen p53

1

7

Small-scale

0.479

High

380535

PTMA
Prothymosin alpha [Cleaved into: Prothymosin alpha, N-terminally processed; Thymosin alpha-1]

1

2

Small-scale

0.479

High

380537

ADRB2
Beta-2 adrenergic receptor

1

1

High-throughput

0.479

High

380540

F16P1
Fructose-1,6-bisphosphatase 1

1

3

High-throughput

0.479

High

380541

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

7

High-throughput

0.479

High

380542

ARAF
Serine/threonine-protein kinase A-Raf

1

5

High-throughput

0.479

High

380546

CFTR
Cystic fibrosis transmembrane conductance regulator

1

16

High-throughput

0.479

High

380547

ITA4
Integrin alpha-4

1

3

High-throughput

0.479

High

380551

IRF2
Interferon regulatory factor 2

1

1

High-throughput

0.479

High

380557

CCNA2
Cyclin-A2

1

1

Small-scale

0.479

High

380558

BTF3
Transcription factor BTF3

1

2

High-throughput

0.479

High

380559

EFNA1
Ephrin-A1

1

19

High-throughput

0.479

High

380562

APC
Adenomatous polyposis coli protein

1

4

Small-scale

0.479

High

380565

SHC1
SHC-transforming protein 1

1

20

High-throughput

0.479

High

380567

CPSM
Carbamoyl-phosphate synthase [ammonia], mitochondrial

1

1

Small-scale

0.479

High

380568

1433S
14-3-3 protein sigma

1

20

Small-scale

0.479

High

380570

ARL2
ADP-ribosylation factor-like protein 2

1

4

High-throughput

0.479

High

380571

ARL3
ADP-ribosylation factor-like protein 3

1

4

High-throughput

0.479

High

380572

TRI23
E3 ubiquitin-protein ligase TRIM23

1

8

High-throughput

0.479

High

380575

EPS15
Epidermal growth factor receptor substrate 15

1

11

High-throughput

0.479

High

380576

MAGA3
Melanoma-associated antigen 3

1

4

Small-scale

0.479

High

380578

CRK
Adapter molecule crk

1

20

High-throughput

0.479

High

380579

YAP1
Transcriptional coactivator YAP1

1

17

Small-scale

0.479

High

380581

ARL4D
ADP-ribosylation factor-like protein 4D

1

3

High-throughput

0.479

High

380584

EFNA4
Ephrin-A4

1

19

High-throughput

0.479

High

380585

TERA
Transitional endoplasmic reticulum ATPase

1

4

High-throughput

0.479

High

380587

MGN
Protein mago nashi homolog

1

2

High-throughput

0.479

High

380588

WDR5
WD repeat-containing protein 5

1

4

High-throughput

0.479

High

380589

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

9

High-throughput

0.479

High

380590

GRB2
Growth factor receptor-bound protein 2

1

13

High-throughput

0.479

High

380591

ARF1
ADP-ribosylation factor 1

1

2

High-throughput

0.479

High

380592

ARF5
ADP-ribosylation factor 5

1

2

High-throughput

0.479

High

380596

KPCE
Protein kinase C epsilon type

1

1

Small-scale

0.479

High

380599

ZO1
Tight junction protein ZO-1

1

6

Small-scale

0.479

High

380601

ARL16
ADP-ribosylation factor-like protein 16

1

7

High-throughput

0.479

High

380602

CHD3
Chromodomain-helicase-DNA-binding protein 3

1

20

High-throughput

0.479

High

380609

DX39B
Spliceosome RNA helicase DDX39B

1

20

Small-scale

0.479

High

380612

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

20

High-throughput

0.479

High

380614

TNIP1
TNFAIP3-interacting protein 1

1

6

High-throughput

0.479

High

380615

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

5

High-throughput

0.479

High

380616

IQCB1
IQ calmodulin-binding motif-containing protein 1

1

15

High-throughput

0.479

High

380622

EZH2
Histone-lysine N-methyltransferase EZH2

1

8

High-throughput

0.479

High

380627

PAN2
PAN2-PAN3 deadenylation complex catalytic subunit PAN2

1

4

High-throughput

0.479

High

380628

MIDN
Midnolin

1

1

High-throughput

0.479

High

380630

VIR
Protein virilizer homolog

1

4

High-throughput

0.479

High

380634

PRP8
Pre-mRNA-processing-splicing factor 8

1

7

High-throughput

0.479

High

380636

RICTR
Rapamycin-insensitive companion of mTOR

1

6

High-throughput

0.479

High

380638

FGD5
FYVE, RhoGEF and PH domain-containing protein 5

1

6

High-throughput

0.479

High

380639

TRI67
Tripartite motif-containing protein 67

1

20

High-throughput

0.479

High

380643

MEPCE
7SK snRNA methylphosphate capping enzyme

1

10

High-throughput

0.479

High

380651

RHG24
Rho GTPase-activating protein 24

1

3

High-throughput

0.479

High

380653

TNIP2
TNFAIP3-interacting protein 2

1

4

High-throughput

0.479

High

380654

RIN3
Ras and Rab interactor 3

1

3

High-throughput

0.479

High

380655

UBS3B
Ubiquitin-associated and SH3 domain-containing protein B

1

19

High-throughput

0.479

High

380656

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

9

High-throughput

0.479

High

380658

HDAC2
Histone deacetylase 2

1

11

High-throughput

0.479

High

380659

TANK
TRAF family member-associated NF-kappa-B activator

1

1

High-throughput

0.479

High

380661

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

3

Small-scale

0.479

High

380664

ZUP1
Zinc finger-containing ubiquitin peptidase 1

1

7

Small-scale

0.479

High

380666

AP2M1
AP-2 complex subunit mu

1

7

High-throughput

0.479

High

380668

RNF31
E3 ubiquitin-protein ligase RNF31

1

14

High-throughput

0.479

High

380672

DDRGK
DDRGK domain-containing protein 1

1

1

High-throughput

0.479

High

380675

TRIB3
Tribbles homolog 3

1

3

Small-scale

0.479

High

380676

NECD
Necdin

1

4

High-throughput

0.479

High

380679

FACD2
Fanconi anemia group D2 protein

1

8

High-throughput

0.479

High

380680

ACE2
Angiotensin-converting enzyme 2

1

6

High-throughput

0.479

High

380682

TRI31
E3 ubiquitin-protein ligase TRIM31

1

10

High-throughput

0.479

High

380683

TRIM7
E3 ubiquitin-protein ligase TRIM7

1

7

Small-scale

0.479

High

380686

DDX24
ATP-dependent RNA helicase DDX24

1

17

High-throughput

0.479

High

380688

RN208
RING finger protein 208

1

20

Small-scale

0.479

High

380690

GAN
Gigaxonin

1

5

High-throughput

0.479

High

380692

RC3H2
Roquin-2

1

11

High-throughput

0.479

High

380693

NMRL1
NmrA-like family domain-containing protein 1

1

1

High-throughput

0.479

High

380696

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

10

High-throughput

0.479

High

380697

ANLN
Anillin

1

11

High-throughput

0.479

High

380698

PIHD1
PIH1 domain-containing protein 1

1

2

High-throughput

0.479

High

380700

HDAC6
Histone deacetylase 6

1

11

High-throughput

0.479

High

380701

KS6B2
Ribosomal protein S6 kinase beta-2

1

5

High-throughput

0.479

High

380702

ZRAN1
Ubiquitin thioesterase ZRANB1

1

11

High-throughput

0.479

High

380703

FBXL4
F-box/LRR-repeat protein 4

1

1

Small-scale

0.479

High

380704

FAF1
FAS-associated factor 1

1

4

High-throughput

0.479

High

380708

TRAF6
TNF receptor-associated factor 6

1

20

Small-scale

0.479

High

380709

UCHL5
Ubiquitin carboxyl-terminal hydrolase isozyme L5

1

9

Small-scale

0.479

High

380710

SAR1B
Small COPII coat GTPase SAR1B

1

4

High-throughput

0.479

High

176528

FANCA
Fanconi anemia group A protein

1

0

Small-scale

0.460

High

380594

FANCC
Fanconi anemia group C protein

1

0

Small-scale

0.460

High

353365

PIGR
Polymeric immunoglobulin receptor

1

0

Small-scale

0.458

High

380544

MBL2
Mannose-binding protein C

1

0

Small-scale

0.458

High

380566

EF1D
Elongation factor 1-delta

1

0

Small-scale

0.458

High

380569

PHB1
Prohibitin 1

1

0

High-throughput

0.458

High

380577

NKX21
Homeobox protein Nkx-2.1

1

0

High-throughput

0.458

High

380582

HDGF
Hepatoma-derived growth factor

1

0

High-throughput

0.458

High

380623

CPEB4
Cytoplasmic polyadenylation element-binding protein 4

1

0

Small-scale

0.458

High

380663

LRC59
Leucine-rich repeat-containing protein 59

1

0

High-throughput

0.458

High

380677

RIOK1
Serine/threonine-protein kinase RIO1

1

0

High-throughput

0.458

High

305888

GBRAP
Gamma-aminobutyric acid receptor-associated protein

1

20

High-throughput

0.445

High

353608

IGHG1
Immunoglobulin heavy constant gamma 1

1

6

High-throughput

0.445

High

353905

IGHM
Immunoglobulin heavy constant mu

1

7

High-throughput

0.445

High

354024

IGHA1
Immunoglobulin heavy constant alpha 1

1

5

High-throughput

0.445

High

380543

TAU
Microtubule-associated protein tau

1

3

High-throughput

0.445

High

380586

GBRL2
Gamma-aminobutyric acid receptor-associated protein-like 2

1

20

High-throughput

0.445

High

380603

CTBP1
C-terminal-binding protein 1

1

4

High-throughput

0.445

High

380610

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

6

High-throughput

0.445

High

380620

MK11
Mitogen-activated protein kinase 11

1

4

Small-scale

0.445

High

380640

NEK10
Serine/threonine-protein kinase Nek10

1

3

High-throughput

0.445

High

380685

MLP3B
Microtubule-associated proteins 1A/1B light chain 3B

1

20

High-throughput

0.445

High

380687

GBRL1
Gamma-aminobutyric acid receptor-associated protein-like 1

1

20

High-throughput

0.445

High

181031

INSI1
Insulin-induced gene 1 protein

1

6

High-throughput

0.437

High

225460

PCDH7
Protocadherin-7

1

2

High-throughput

0.437

High

380580

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

1

High-throughput

0.437

High

380583

EFNA3
Ephrin-A3

1

19

High-throughput

0.437

High

380625

MINY4
Probable ubiquitin carboxyl-terminal hydrolase MINDY-4

1

2

Small-scale

0.437

High

380629

RC3H1
Roquin-1

1

5

High-throughput

0.437

High

380635

FBX42
F-box only protein 42

1

1

High-throughput

0.437

High

380637

LRC31
Leucine-rich repeat-containing protein 31

1

7

High-throughput

0.437

High

380641

ASXL2
Putative Polycomb group protein ASXL2

1

6

High-throughput

0.437

High

380642

KCTD9
BTB/POZ domain-containing protein KCTD9

1

1

High-throughput

0.437

High

380652

ARL10
ADP-ribosylation factor-like protein 10

1

4

High-throughput

0.437

High

380671

DIRA2
GTP-binding protein Di-Ras2

1

1

Small-scale

0.437

High

380673

ARL5B
ADP-ribosylation factor-like protein 5B

1

3

High-throughput

0.437

High

380678

LGR4
Leucine-rich repeat-containing G-protein coupled receptor 4

1

5

High-throughput

0.437

High

380684

ASXL3
Putative Polycomb group protein ASXL3

1

2

High-throughput

0.437

High

380689

UN93B
Protein unc-93 homolog B1

1

1

High-throughput

0.437

High

380707

AAR2
Protein AAR2 homolog

1

5

High-throughput

0.437

High

135195

E2F3
Transcription factor E2F3

1

0

Small-scale

0.426

High

275362

PR15A
Protein phosphatase 1 regulatory subunit 15A

1

0

High-throughput

0.426

High

881

SIM26
Small integral membrane protein 26

1

6

High-throughput

0.407

High


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024