HitPredict

Interactor 1: TNFA (P06804)
Tumor necrosis factor (Cachectin) (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) [Cleaved into: Tumor necrosis factor, membrane form (N-terminal fragment) (NTF); Intracellular domain 1 (ICD1); Intracellular domain 2 (ICD2); C-domain 1; C-domain 2; Tumor necrosis factor, soluble form]
Gene: Tnf

Interactor 2: TBK1 (Q9WUN2)
Serine/threonine-protein kinase TBK1 (EC 2.7.11.1) (T2K) (TANK-binding kinase 1)
Gene: TBK1

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	30420664
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0010629 - negative regulation of gene expression GO:0043123 - positive regulation of canonical NF-kappaB signal transduction GO:0045944 - positive regulation of transcription by RNA polymerase II GO:0050830 - defense response to Gram-positive bacterium GO:0140374 - antiviral innate immune response
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 235 Mm			1 729
+	Hs
		352717 TNFA_HUMAN (1-235): 2.1e-104: 303: 78.39		TBK1_HUMAN (1-729): 0: 562: 94.10
+	Mm
		420408 TNFA_MOUSE (1-235): 4.5e-105: 305: 100.00		IKKE_MOUSE (1-715): 1.11e-155: 470: 46.58
+	Hs
		352612 TNFA_HUMAN (1-235): 2.1e-104: 303: 78.39		IKKE_HUMAN (1-715): 7.37e-150: 455: 48.54
+	Hs
		158362 TNFA_HUMAN (1-235): 2.1e-104: 303: 78.39		IKKB_HUMAN (9-709): 4.06e-128: 400: 18.63
+	Mm
		291434 TNFA_MOUSE (1-235): 4.5e-105: 305: 100.00		IKKB_MOUSE (9-709): 3.3e-126: 395: 18.90
+	Hs
		167437 TNFA_HUMAN (1-235): 2.1e-104: 303: 78.39		IKKA_HUMAN (9-643): 5.48e-119: 375: 20.53