HitPredict

Interactor 1: TNFA (P06804)
Tumor necrosis factor (Cachectin) (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) [Cleaved into: Tumor necrosis factor, membrane form (N-terminal fragment) (NTF); Intracellular domain 1 (ICD1); Intracellular domain 2 (ICD2); C-domain 1; C-domain 2; Tumor necrosis factor, soluble form]
Gene: Tnf

Interactor 2: NFAT5 (Q9WV30)
Nuclear factor of activated T-cells 5 (NF-AT5) (Rel domain-containing transcription factor NFAT5) (T-cell transcription factor NFAT5)
Gene: NFAT5

Species: Mus musculus

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	20685965
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0010628 - positive regulation of gene expression GO:0043123 - positive regulation of canonical NF-kappaB signal transduction GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 235 Mm			1 1534
+	Hs
		300514 TNFA_HUMAN (1-235): 2.1e-104: 303: 78.39		NFAT5_HUMAN (1-1534): 0: 787: 91.35
+	Mm
		420392 TNFA_MOUSE (1-235): 4.5e-105: 305: 100.00		NFKB1_MOUSE (271-779): 1.62e-91: 322: 15.17
+	Hs
		352589 TNFA_HUMAN (1-235): 2.1e-104: 303: 78.39		TF65_HUMAN (267-788): 2.88e-74: 260: 17.59
+	Mm
		420397 TNFA_MOUSE (1-235): 4.5e-105: 305: 100.00		TF65_MOUSE (267-788): 1.37e-71: 252: 17.22
+	Hs
		352598 TNFA_HUMAN (1-235): 2.1e-104: 303: 78.39		NFAC3_HUMAN (267-821): 3.79e-66: 247: 28.30
+	Mm
		420398 TNFA_MOUSE (1-235): 4.5e-105: 305: 100.00		RELB_MOUSE (274-719): 5.33e-67: 239: 15.24
+	Hs
		352584 TNFA_HUMAN (1-235): 2.1e-104: 303: 78.39		RELB_HUMAN (269-719): 3.66e-63: 228: 15.69
+	Mm
		78126 TNFA_MOUSE (1-235): 4.5e-105: 305: 100.00		B5B2U4_MOUSE (267-821): 1.28e-59: 226: 28.20
+	Hs
		352617 TNFA_HUMAN (1-235): 2.1e-104: 303: 78.39		NFAC4_HUMAN (267-732): 1.13e-57: 218: 28.22
+	Hs
		352606 TNFA_HUMAN (1-235): 2.1e-104: 303: 78.39		NFAC2_HUMAN (267-685): 4.08e-57: 217: 33.33
+	Hs
		317883 TNFA_HUMAN (1-235): 2.1e-104: 303: 78.39		NFAC1_HUMAN (267-810): 6.67e-51: 198: 27.59
+	Hs
		669879 CD40L_HUMAN (83-235): 6.82e-37: 131: 22.98		REL_HUMAN (273-829): 3.19e-89: 305: 16.16
+	Hs
		155683 TNF11_HUMAN (49-235): 5.29e-58: 188: 20.10		NFAC3_HUMAN (267-821): 3.79e-66: 247: 28.30
+	Hs
		352671 TNFA_HUMAN (1-235): 2.1e-104: 303: 78.39		CBP_HUMAN (768-1462): 2.19e-09: 64.8: 11.94
+	Hs
		669883 CD40L_HUMAN (83-235): 6.82e-37: 131: 22.98		NFAC2_HUMAN (267-685): 4.08e-57: 217: 33.33
+	Hs
		317913 CD40L_HUMAN (83-235): 6.82e-37: 131: 22.98		NFAC1_HUMAN (267-810): 6.67e-51: 198: 27.59