Protein: STAT3
Signal transducer and activator of transcription 3 (Acute-phase response factor)

Gene: STAT3
Organism: Homo sapiens
Interactions: 476
UniProt ID: P40763

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0000976 - transcription cis-regulatory region binding
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

362902

EGFR
Epidermal growth factor receptor

20

20

Small-scale

0.989

High

827688

STAT1
Signal transducer and activator of transcription 1-alpha/beta

12

17

Small-scale

0.978

High

827684

STAT3
Signal transducer and activator of transcription 3

13

16

Small-scale

0.974

High

253318

JAK2
Tyrosine-protein kinase JAK2

11

20

Small-scale

0.972

High

827712

BMX
Cytoplasmic tyrosine-protein kinase BMX

8

17

Small-scale

0.966

High

607539

PTN2
Tyrosine-protein phosphatase non-receptor type 2

7

18

Small-scale

0.959

High

827693

KSYK
Tyrosine-protein kinase SYK

6

20

Small-scale

0.949

High

557147

SRC
Proto-oncogene tyrosine-protein kinase Src

6

16

Small-scale

0.947

High

827706

BLK
Tyrosine-protein kinase Blk

5

16

High-throughput

0.925

High

658648

JAK1
Tyrosine-protein kinase JAK1

5

20

Small-scale

0.912

High

827691

MTOR
Serine/threonine-protein kinase mTOR

4

3

Small-scale

0.899

High

410680

ERBB2
Receptor tyrosine-protein kinase erbB-2

4

20

Small-scale

0.881

High

827779

LRC32
Transforming growth factor beta activator LRRC32

3

1

High-throughput

0.855

High

463916

RET
Proto-oncogene tyrosine-protein kinase receptor Ret

3

20

Small-scale

0.847

High

827755

PTN11
Tyrosine-protein phosphatase non-receptor type 11

3

18

Small-scale

0.827

High

439978

LCK
Tyrosine-protein kinase Lck

3

16

Small-scale

0.827

High

213845

M3K7
Mitogen-activated protein kinase kinase kinase 7

2

4

Small-scale

0.802

High

611020

PTN1
Tyrosine-protein phosphatase non-receptor type 1

2

18

Small-scale

0.789

High

486666

FGR
Tyrosine-protein kinase Fgr

2

16

Small-scale

0.767

High

136320

P85B
Phosphatidylinositol 3-kinase regulatory subunit beta

2

20

High-throughput

0.767

High

699623

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

2

4

High-throughput

0.767

High

827692

ABL2
Tyrosine-protein kinase ABL2

2

15

High-throughput

0.767

High

827867

P55G
Phosphatidylinositol 3-kinase regulatory subunit gamma

2

20

High-throughput

0.767

High

827931

SH22A
SH2 domain-containing protein 2A

2

16

High-throughput

0.767

High

827777

FAK2
Protein-tyrosine kinase 2-beta

2

20

Small-scale

0.763

High

827761

EP300
Histone acetyltransferase p300

11

13

Small-scale

0.755

High

463385

LYN
Tyrosine-protein kinase Lyn

2

16

Small-scale

0.755

High

465440

IGF1R
Insulin-like growth factor 1 receptor

2

13

Small-scale

0.754

High

820514

IL6RB
Interleukin-6 receptor subunit beta

2

8

Small-scale

0.754

High

827964

ALK
ALK tyrosine kinase receptor

2

20

Small-scale

0.754

High

155154

SOCS7
Suppressor of cytokine signaling 7

1

18

Small-scale

0.740

High

827979

PIAS3
E3 SUMO-protein ligase PIAS3

7

5

Small-scale

0.737

High

827753

KPCD
Protein kinase C delta type

1

7

Small-scale

0.724

High

827795

CIP4
Cdc42-interacting protein 4

1

2

Small-scale

0.724

High

827750

TF65
Transcription factor p65

5

5

Small-scale

0.713

High

212012

M3K13
Mitogen-activated protein kinase kinase kinase 13

1

5

High-throughput

0.698

High

827689

STAT6
Signal transducer and activator of transcription 6

1

16

High-throughput

0.698

High

827698

PA24A
Cytosolic phospholipase A2

1

2

High-throughput

0.691

High

827881

SPSB4
SPRY domain-containing SOCS box protein 4

1

7

High-throughput

0.691

High

464857

SP1
Transcription factor Sp1

4

4

Small-scale

0.691

High

827771

HDAC1
Histone deacetylase 1

4

11

Small-scale

0.687

High

827804

HIF1A
Hypoxia-inducible factor 1-alpha

4

6

Small-scale

0.683

High

519808

ANDR
Androgen receptor

4

18

Small-scale

0.680

High

403888

GCR
Glucocorticoid receptor

4

19

Small-scale

0.676

High

188197

HDAC3
Histone deacetylase 3

4

10

Small-scale

0.676

High

533892

IRF1
Interferon regulatory factor 1

4

20

Small-scale

0.676

High

827838

TRI59
Tripartite motif-containing protein 59

4

5

Small-scale

0.676

High

588092

RFA2
Replication protein A 32 kDa subunit

3

2

Small-scale

0.666

High

827715

JAK3
Tyrosine-protein kinase JAK3

1

20

Small-scale

0.665

High

664660

CCND1
G1/S-specific cyclin-D1

3

5

Small-scale

0.664

High

249102

DSCAM
Cell adhesion molecule DSCAM

1

0

High-throughput

0.663

High

827846

I22R1
Interleukin-22 receptor subunit alpha-1

3

14

Small-scale

0.661

High

827694

MK08
Mitogen-activated protein kinase 8

3

8

Small-scale

0.660

High

827817

VASN
Vasorin

1

0

High-throughput

0.656

High

827912

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

3

5

High-throughput

0.654

High

440422

FYN
Tyrosine-protein kinase Fyn

1

16

Small-scale

0.647

High

473377

HCK
Tyrosine-protein kinase HCK

1

16

Small-scale

0.647

High

533835

GHR
Growth hormone receptor

1

20

Small-scale

0.647

High

827943

PHAG1
Phosphoprotein associated with glycosphingolipid-enriched microdomains 1

1

3

Small-scale

0.646

High

827973

TRAF6
TNF receptor-associated factor 6

3

7

Small-scale

0.640

High

721142

SORCN
Sorcin

2

3

Small-scale

0.640

High

291627

XRP2
Protein XRP2

3

0

High-throughput

0.638

High

827792

TCAL1
Transcription elongation factor A protein-like 1

3

0

High-throughput

0.638

High

827934

TRPV5
Transient receptor potential cation channel subfamily V member 5

3

0

High-throughput

0.638

High

827978

CCG2
Voltage-dependent calcium channel gamma-2 subunit

3

0

High-throughput

0.638

High

827825

Q6ZVU3
cDNA FLJ42079 fis, clone SYNOV2021320, highly similar to SH3 DOMAIN-BINDING PROTEIN 3BP-2

1

1

High-throughput

0.637

High

827891

BICD1
Protein bicaudal D homolog 1

2

5

High-throughput

0.631

High

827897

CDK15
Cyclin-dependent kinase 15

2

1

High-throughput

0.628

High

827958

I20RA
Interleukin-20 receptor subunit alpha

2

20

High-throughput

0.628

High

827733

GRB2
Growth factor receptor-bound protein 2

1

13

Small-scale

0.625

High

827902

CSF3R
Granulocyte colony-stimulating factor receptor

1

8

Small-scale

0.625

High

606359

CEBPB
CCAAT/enhancer-binding protein beta

2

8

Small-scale

0.624

High

713912

PML
Protein PML

2

14

Small-scale

0.624

High

827781

HIC1
Hypermethylated in cancer 1 protein

2

2

Small-scale

0.624

High

827797

NCOA1
Nuclear receptor coactivator 1

2

10

Small-scale

0.624

High

827738

3BP2
SH3 domain-binding protein 2

1

1

High-throughput

0.621

High

827848

CE120
Centrosomal protein of 120 kDa

1

4

High-throughput

0.621

High

827915

IKBZ
NF-kappa-B inhibitor zeta

2

8

Small-scale

0.619

High

155410

PTPRT
Receptor-type tyrosine-protein phosphatase T

1

1

Small-scale

0.618

High

155919

SOCS3
Suppressor of cytokine signaling 3

1

20

Small-scale

0.618

High

247245

PHLP1
PH domain leucine-rich repeat-containing protein phosphatase 1

1

2

High-throughput

0.618

High

400417

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

5

High-throughput

0.618

High

411504

NTRK1
High affinity nerve growth factor receptor

1

19

High-throughput

0.618

High

424641

KPCG
Protein kinase C gamma type

1

8

Small-scale

0.618

High

439673

INSR
Insulin receptor

1

14

Small-scale

0.618

High

456096

FES
Tyrosine-protein kinase Fes/Fps

1

18

Small-scale

0.618

High

472012

MET
Hepatocyte growth factor receptor

1

18

Small-scale

0.618

High

541379

FGFR1
Fibroblast growth factor receptor 1

1

16

Small-scale

0.618

High

599170

IL7RA
Interleukin-7 receptor subunit alpha

1

2

High-throughput

0.618

High

609957

VGFR1
Vascular endothelial growth factor receptor 1

1

13

Small-scale

0.618

High

641133

FGFR2
Fibroblast growth factor receptor 2

1

19

Small-scale

0.618

High

711049

PTN6
Tyrosine-protein phosphatase non-receptor type 6

1

13

Small-scale

0.618

High

778032

VGFR2
Vascular endothelial growth factor receptor 2

1

13

Small-scale

0.618

High

827690

STA5A
Signal transducer and activator of transcription 5A

1

16

Small-scale

0.618

High

827710

STA5B
Signal transducer and activator of transcription 5B

1

16

Small-scale

0.618

High

827716

STAT2
Signal transducer and activator of transcription 2

1

16

Small-scale

0.618

High

827721

EPHA5
Ephrin type-A receptor 5

1

11

Small-scale

0.618

High

827724

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

3

High-throughput

0.618

High

827744

IRF9
Interferon regulatory factor 9

1

20

Small-scale

0.618

High

827748

ROR1
Inactive tyrosine-protein kinase transmembrane receptor ROR1

1

20

Small-scale

0.618

High

827752

FAK1
Focal adhesion kinase 1

1

20

Small-scale

0.618

High

827756

BTK
Tyrosine-protein kinase BTK

1

16

Small-scale

0.618

High

827785

STAT4
Signal transducer and activator of transcription 4

1

17

Small-scale

0.618

High

827823

TRI67
Tripartite motif-containing protein 67

1

8

High-throughput

0.618

High

827896

NED4L
E3 ubiquitin-protein ligase NEDD4-like

1

6

Small-scale

0.618

High

827938

SH2B1
SH2B adapter protein 1

1

14

Small-scale

0.618

High

442891

PRGR
Progesterone receptor

2

17

Small-scale

0.612

High

628607

CAP7
Azurocidin

2

3

High-throughput

0.611

High

552522

IMDH2
Inosine-5'-monophosphate dehydrogenase 2

2

1

High-throughput

0.606

High

827892

P121A
Nuclear envelope pore membrane protein POM 121

2

4

High-throughput

0.606

High

827801

NF2L2
Nuclear factor erythroid 2-related factor 2

1

9

Small-scale

0.603

High

684943

DNMT1
DNA

2

2

Small-scale

0.601

High

703470

MK01
Mitogen-activated protein kinase 1

2

5

Small-scale

0.601

High

827873

CBP
CREB-binding protein

2

14

Small-scale

0.595

High

827799

EZH2
Histone-lysine N-methyltransferase EZH2

2

1

Small-scale

0.594

High

249724

DOK2
Docking protein 2

2

2

High-throughput

0.594

High

651199

CBL
E3 ubiquitin-protein ligase CBL

2

9

High-throughput

0.594

High

827700

MAPK2
MAP kinase-activated protein kinase 2

2

3

High-throughput

0.594

High

827749

PPARD
Peroxisome proliferator-activated receptor delta

2

16

High-throughput

0.594

High

827786

LASP1
LIM and SH3 domain protein 1

2

1

High-throughput

0.594

High

827796

TWST1
Twist-related protein 1

2

2

High-throughput

0.594

High

827808

ZN829
Zinc finger protein 829

2

2

High-throughput

0.594

High

827812

TASO2
Protein TASOR 2

2

1

High-throughput

0.594

High

827827

DOK3
Docking protein 3

2

2

High-throughput

0.594

High

827842

WDFY3
WD repeat and FYVE domain-containing protein 3

2

1

High-throughput

0.594

High

827893

VPS39
Vam6/Vps39-like protein

2

1

High-throughput

0.594

High

827939

BRWD1
Bromodomain and WD repeat-containing protein 1

2

5

High-throughput

0.594

High

827954

HESX1
Homeobox expressed in ES cells 1

2

1

High-throughput

0.594

High

827969

ZN281
Zinc finger protein 281

2

1

High-throughput

0.594

High

827899

ERBIN
Erbin

1

0

High-throughput

0.589

High

395628

ESR1
Estrogen receptor

2

20

Small-scale

0.586

High

827834

SIAH1
E3 ubiquitin-protein ligase SIAH1

2

1

Small-scale

0.586

High

827879

FBXW7
F-box/WD repeat-containing protein 7

2

4

Small-scale

0.586

High

827948

MYOF
Myoferlin

1

0

Small-scale

0.586

High

827965

DD19B
ATP-dependent RNA helicase DDX19B

2

0

High-throughput

0.585

High

131784

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

2

6

Small-scale

0.584

High

240964

PRKN
E3 ubiquitin-protein ligase parkin

2

3

High-throughput

0.584

High

259562

BRD4
Bromodomain-containing protein 4

2

4

Small-scale

0.584

High

370591

FOS
Protein c-Fos

2

11

Small-scale

0.584

High

461232

HS90A
Heat shock protein HSP 90-alpha

2

5

Small-scale

0.584

High

717389

PDIA3
Protein disulfide-isomerase A3

2

2

Small-scale

0.584

High

807971

CDN1A
Cyclin-dependent kinase inhibitor 1

2

1

Small-scale

0.584

High

827856

BICD2
Protein bicaudal D homolog 2

2

5

Small-scale

0.584

High

827900

UBP28
Ubiquitin carboxyl-terminal hydrolase 28

2

7

Small-scale

0.584

High

246459

KDM1A
Lysine-specific histone demethylase 1A

1

3

Small-scale

0.578

High

827705

CDK9
Cyclin-dependent kinase 9

1

7

Small-scale

0.578

High

827707

SMCA4
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4

1

5

Small-scale

0.578

High

827766

TIF1B
Transcription intermediary factor 1-beta

1

11

Small-scale

0.578

High

827780

HES1
Transcription factor HES-1

1

3

Small-scale

0.578

High

176760

NACAD
NAC-alpha domain-containing protein 1

2

1

High-throughput

0.576

High

617131

ATF3
Cyclic AMP-dependent transcription factor ATF-3

2

18

High-throughput

0.576

High

827686

MNDA
Myeloid cell nuclear differentiation antigen

2

1

High-throughput

0.576

High

827849

ZN557
Zinc finger protein 557

2

2

High-throughput

0.576

High

827861

CTF18
Chromosome transmission fidelity protein 18 homolog

2

1

High-throughput

0.576

High

827933

NXT2
NTF2-related export protein 2

2

1

High-throughput

0.576

High

827936

BATF3
Basic leucine zipper transcriptional factor ATF-like 3

2

13

High-throughput

0.576

High

827960

KLF15
Krueppel-like factor 15

2

5

High-throughput

0.576

High

650073

FGFR3
Fibroblast growth factor receptor 3

1

20

Small-scale

0.575

High

827759

DDR1
Epithelial discoidin domain-containing receptor 1

1

19

Small-scale

0.575

High

827940

TB22B
TBC1 domain family member 22B

2

1

High-throughput

0.574

High

457056

CAN1
Calpain-1 catalytic subunit

1

3

High-throughput

0.573

High

652465

NR4A1
Nuclear receptor subfamily 4immunitygroup A member 1

1

19

High-throughput

0.573

High

724369

COR1A
Coronin-1A

1

5

High-throughput

0.573

High

827763

ECH1
Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial

1

2

High-throughput

0.573

High

827818

ELP2
Elongator complex protein 2

1

5

Small-scale

0.573

High

827841

PELP1
Proline-, glutamic acid- and leucine-rich protein 1

1

11

Small-scale

0.573

High

681766

RBTN2
Rhombotin-2

1

3

High-throughput

0.573

High

764223

CAH8
Carbonic anhydrase-related protein

2

0

High-throughput

0.569

High

827728

KR107
Keratin-associated protein 10-7

2

0

High-throughput

0.569

High

827829

NUFP2
FMR1-interacting protein NUFIP2

2

0

High-throughput

0.569

High

827832

PAQR7
Membrane progestin receptor alpha

2

0

High-throughput

0.569

High

827850

GSTCD
Glutathione S-transferase C-terminal domain-containing protein

2

0

High-throughput

0.569

High

827887

T4S19
Transmembrane 4 L6 family member 19

2

0

High-throughput

0.569

High

827941

CCD87
Coiled-coil domain-containing protein 87

2

0

High-throughput

0.569

High

827971

RBGP1
Rab GTPase-activating protein 1

2

0

High-throughput

0.569

High

827972

DTNA
Dystrobrevin alpha

2

0

High-throughput

0.569

High

827854

G45IP
Large ribosomal subunit protein mL64

2

0

Small-scale

0.566

High

429446

JUN
Transcription factor Jun

1

12

Small-scale

0.561

High

581629

MYOD1
Myoblast determination protein 1

1

3

Small-scale

0.561

High

626110

NFKB1
Nuclear factor NF-kappa-B p105 subunit

1

10

Small-scale

0.561

High

827811

HES5
Transcription factor HES-5

1

3

Small-scale

0.561

High

827844

TAB3
TGF-beta-activated kinase 1 and MAP3K7-binding protein 3

1

5

Small-scale

0.561

High

827888

SIR1
NAD-dependent protein deacetylase sirtuin-1

2

0

Small-scale

0.559

High

827695

MK09
Mitogen-activated protein kinase 9

1

8

Small-scale

0.554

High

827860

SETD7
Histone-lysine N-methyltransferase SETD7

1

0

Small-scale

0.554

High

827734

RAC1
Ras-related C3 botulinum toxin substrate 1

1

1

Small-scale

0.552

High

827949

NDUAD
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13

1

1

Small-scale

0.552

High

827737

PA1B2
Platelet-activating factor acetylhydrolase IB subunit alpha2

2

0

High-throughput

0.551

High

827772

TDG
G/T mismatch-specific thymine DNA glycosylase

2

0

High-throughput

0.551

High

827894

CNDP2
Cytosolic non-specific dipeptidase

2

0

High-throughput

0.551

High

827697

RS9
Small ribosomal subunit protein uS4

1

0

High-throughput

0.549

High

827757

ST2A1
Sulfotransferase 2A1

1

0

High-throughput

0.549

High

827859

MORC4
MORC family CW-type zinc finger protein 4

1

0

High-throughput

0.549

High

827870

RT31
Small ribosomal subunit protein mS31

1

0

High-throughput

0.549

High

827910

GNL3
Guanine nucleotide-binding protein-like 3

1

0

High-throughput

0.549

High

211222

HXC11
Homeobox protein Hox-C11

1

1

High-throughput

0.541

High

273983

CREST
Calcium-responsive transactivator

1

5

High-throughput

0.541

High

442624

RB
Retinoblastoma-associated protein

1

0

Small-scale

0.537

High

827901

SIN3A
Paired amphipathic helix protein Sin3a

1

0

Small-scale

0.537

High

827935

RPR1B
Regulation of nuclear pre-mRNA domain-containing protein 1B

1

0

Small-scale

0.537

High

388162

GLPA
Glycophorin-A

1

2

High-throughput

0.536

High

580738

PVR
Poliovirus receptor

1

1

High-throughput

0.536

High

664034

PRTN3
Myeloblastin

1

3

High-throughput

0.536

High

733299

CCR1
C-C chemokine receptor type 1

1

6

High-throughput

0.536

High

827741

SSBP2
Single-stranded DNA-binding protein 2

1

1

High-throughput

0.536

High

827802

C3AR
C3a anaphylatoxin chemotactic receptor

1

5

High-throughput

0.536

High

827836

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

1

High-throughput

0.536

High

827882

EFMT3
EEF1A lysine methyltransferase 3

1

3

High-throughput

0.536

High

827918

SEM4C
Semaphorin-4C

1

1

High-throughput

0.536

High

827961

PHF11
PHD finger protein 11

1

3

High-throughput

0.536

High

827974

RN115
E3 ubiquitin-protein ligase RNF115

1

1

High-throughput

0.536

High

827976

GPR45
Probable G-protein coupled receptor 45

1

4

High-throughput

0.536

High

766140

NOS2
Nitric oxide synthase, inducible

1

3

Small-scale

0.534

High

827767

NMI
N-myc-interactor

1

6

Small-scale

0.527

High

166627

BCKD
Branched-chain alpha-ketoacid dehydrogenase kinase

1

2

High-throughput

0.523

High

827962

OGDHL
2-oxoglutarate dehydrogenase-like, mitochondrial

1

2

High-throughput

0.523

High

827921

PHS2
Pterin-4-alpha-carbinolamine dehydratase 2

1

0

High-throughput

0.518

High

212641

DAPK3
Death-associated protein kinase 3

1

3

Small-scale

0.515

High

270781

ROCK2
Rho-associated protein kinase 2

1

1

Small-scale

0.515

High

584672

MCP
Membrane cofactor protein

1

2

Small-scale

0.515

High

642681

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

1

High-throughput

0.515

High

827685

CCNF
Cyclin-F

1

1

High-throughput

0.515

High

827708

IRAK1
Interleukin-1 receptor-associated kinase 1

1

2

Small-scale

0.515

High

827743

NFKB2
Nuclear factor NF-kappa-B p100 subunit

1

10

Small-scale

0.515

High

421638

A4
Amyloid-beta precursor protein

1

2

High-throughput

0.515

High

827725

STX17
Syntaxin-17

1

0

High-throughput

0.513

High

827727

TIRAP
Toll/interleukin-1 receptor domain-containing adapter protein

1

0

High-throughput

0.513

High

827742

2ABB
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

1

0

High-throughput

0.513

High

827815

MBLC2
Acyl-coenzyme A thioesterase MBLAC2

1

0

High-throughput

0.513

High

827831

KIF27
Kinesin-like protein KIF27

1

0

High-throughput

0.513

High

827908

MMTA2
Multiple myeloma tumor-associated protein 2

1

0

High-throughput

0.513

High

827928

PACC1
Proton-activated chloride channel

1

0

High-throughput

0.513

High

827937

MBNL1
Muscleblind-like protein 1

1

0

High-throughput

0.513

High

827942

EKI2
Ethanolamine kinase 2

1

0

High-throughput

0.513

High

827968

SSUH2
Protein SSUH2 homolog

1

0

High-throughput

0.513

High

827977

LRRF2
Leucine-rich repeat flightless-interacting protein 2

1

0

High-throughput

0.513

High

827955

DAXX
Death domain-associated protein 6

1

0

Small-scale

0.512

High

827776

FHL2
Four and a half LIM domains protein 2

1

2

Small-scale

0.508

High

443020

PTMA
Prothymosin alpha [Cleaved into: Prothymosin alpha, N-terminally processed; Thymosin alpha-1]

1

0

Small-scale

0.506

High

575813

IL2RB
Interleukin-2 receptor subunit beta

1

20

Small-scale

0.501

High

827711

KS6A3
Ribosomal protein S6 kinase alpha-3

1

2

Small-scale

0.501

High

827722

RAD
GTP-binding protein RAD

1

1

Small-scale

0.501

High

827740

GTF2I
General transcription factor II-I

1

1

Small-scale

0.501

High

827794

KS6A1
Ribosomal protein S6 kinase alpha-1

1

2

Small-scale

0.501

High

827889

RNF31
E3 ubiquitin-protein ligase RNF31

1

7

Small-scale

0.501

High

359604

DHE3
Glutamate dehydrogenase 1, mitochondrial

1

1

High-throughput

0.500

High

827760

LG3BP
Galectin-3-binding protein

1

2

High-throughput

0.500

High

827864

SYNE2
Nesprin-2

1

5

High-throughput

0.500

High

697031

APEX1
DNA repair nuclease/redox regulator APEX1

1

0

Small-scale

0.493

High

751305

DUT
Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial

1

0

High-throughput

0.493

High

827758

KHDR1
KH domain-containing, RNA-binding, signal transduction-associated protein 1

1

0

Small-scale

0.493

High

827787

NFIX
Nuclear factor 1 X-type

1

0

Small-scale

0.493

High

827945

HIF1N
Hypoxia-inducible factor 1-alpha inhibitor

1

0

High-throughput

0.493

High

827963

HECD1
E3 ubiquitin-protein ligase HECTD1

1

6

High-throughput

0.489

High

827951

NLK
Serine/threonine-protein kinase NLK

1

6

Small-scale

0.484

High

827975

RBM8A
RNA-binding protein 8A

1

1

Small-scale

0.484

High

211543

SIAH2
E3 ubiquitin-protein ligase SIAH2

1

3

High-throughput

0.481

High

333446

MPZL1
Myelin protein zero-like protein 1

1

1

High-throughput

0.481

High

389625

AMBP
Protein AMBP

1

2

High-throughput

0.481

High

412938

CPNS1
Calpain small subunit 1

1

3

High-throughput

0.481

High

458311

ADRB2
Beta-2 adrenergic receptor

1

2

Small-scale

0.481

High

586242

ZEP1
Zinc finger protein 40

1

1

High-throughput

0.481

High

827713

HNRPM
Heterogeneous nuclear ribonucleoprotein M

1

1

High-throughput

0.481

High

827701

TCPG
T-complex protein 1 subunit gamma

1

0

Small-scale

0.480

High

216166

MTG8R
Protein CBFA2T2

1

0

Small-scale

0.479

High

285605

BAF
Barrier-to-autointegration factor

1

0

High-throughput

0.479

High

732256

PRDX2
Peroxiredoxin-2

1

0

Small-scale

0.479

High

827885

S2536
Solute carrier family 25 member 36

1

0

High-throughput

0.479

High

827909

HNRL1
Heterogeneous nuclear ribonucleoprotein U-like protein 1

1

0

High-throughput

0.479

High

141198

SOX1
Transcription factor SOX-1

1

1

Small-scale

0.479

High

154946

BHE40
Class E basic helix-loop-helix protein 40

1

3

Small-scale

0.479

High

157042

CTRO
Citron Rho-interacting kinase

1

2

High-throughput

0.479

High

167845

IKKB
Inhibitor of nuclear factor kappa-B kinase subunit beta

1

2

Small-scale

0.479

High

180736

TIF1A
Transcription intermediary factor 1-alpha

1

20

Small-scale

0.479

High

184599

MK13
Mitogen-activated protein kinase 13

1

8

Small-scale

0.479

High

369537

ANGT
Angiotensinogen

1

1

Small-scale

0.479

High

371366

MYC
Myc proto-oncogene protein

1

4

Small-scale

0.479

High

378418

IFNG
Interferon gamma

1

3

Small-scale

0.479

High

378551

IL1B
Interleukin-1 beta

1

1

Small-scale

0.479

High

387954

FIBG
Fibrinogen gamma chain

1

4

Small-scale

0.479

High

413333

P53
Cellular tumor antigen p53

1

3

High-throughput

0.479

High

415397

HSPB1
Heat shock protein beta-1

1

4

Small-scale

0.479

High

427822

ICAM1
Intercellular adhesion molecule 1

1

3

Small-scale

0.479

High

430704

REG1A
Lithostathine-1-alpha

1

1

Small-scale

0.479

High

456643

ANXA2
Annexin A2

1

1

Small-scale

0.479

High

466634

GLI1
Zinc finger protein GLI1

1

3

Small-scale

0.479

High

474528

VIME
Vimentin

1

4

Small-scale

0.479

High

477101

IL6RA
Interleukin-6 receptor subunit alpha

1

16

Small-scale

0.479

High

555926

CADH1
Cadherin-1

1

2

Small-scale

0.479

High

573366

ENPL
Endoplasmin

1

5

Small-scale

0.479

High

576183

PO2F1
POU domain, class 2, transcription factor 1

1

5

Small-scale

0.479

High

585443

VEGFA
Vascular endothelial growth factor A, long form

1

1

Small-scale

0.479

High

596965

TSHR
Thyrotropin receptor

1

2

Small-scale

0.479

High

598023

AT2A2
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2

1

1

High-throughput

0.479

High

599557

STMN1
Stathmin

1

2

Small-scale

0.479

High

602877

INAR1
Interferon alpha/beta receptor 1

1

16

Small-scale

0.479

High

612913

EGR1
Early growth response protein 1

1

1

High-throughput

0.479

High

624004

E2AK2
Interferon-induced, double-stranded RNA-activated protein kinase

1

11

Small-scale

0.479

High

634912

BCL3
B-cell lymphoma 3 protein

1

8

Small-scale

0.479

High

635170

HNF1A
Hepatocyte nuclear factor 1-alpha

1

1

Small-scale

0.479

High

636712

PTN
Pleiotrophin

1

1

Small-scale

0.479

High

639200

TNAP3
Tumor necrosis factor alpha-induced protein 3

1

4

Small-scale

0.479

High

647306

IL10
Interleukin-10

1

1

Small-scale

0.479

High

665239

GA45A
Growth arrest and DNA damage-inducible protein GADD45 alpha

1

1

Small-scale

0.479

High

691654

MK03
Mitogen-activated protein kinase 3

1

5

Small-scale

0.479

High

694807

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.479

High

730426

1433S
14-3-3 protein sigma

1

1

High-throughput

0.479

High

748672

IL3RB
Cytokine receptor common subunit beta

1

19

Small-scale

0.479

High

767584

RFA3
Replication protein A 14 kDa subunit

1

2

High-throughput

0.479

High

773434

COPB2
Coatomer subunit beta'

1

1

High-throughput

0.479

High

789069

NUP62
Nuclear pore glycoprotein p62

1

1

High-throughput

0.479

High

827687

CCR2
C-C chemokine receptor type 2

1

6

Small-scale

0.479

High

827696

MP2K3
Dual specificity mitogen-activated protein kinase kinase 3

1

6

Small-scale

0.479

High

827699

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

6

High-throughput

0.479

High

827703

VEGFC
Vascular endothelial growth factor C

1

1

Small-scale

0.479

High

827709

CCR5
C-C chemokine receptor type 5

1

6

Small-scale

0.479

High

827714

IMA5
Importin subunit alpha-5

1

3

Small-scale

0.479

High

827717

PLK1
Serine/threonine-protein kinase PLK1

1

3

Small-scale

0.479

High

827720

COPA
Coatomer subunit alpha

1

1

High-throughput

0.479

High

827729

1433G
14-3-3 protein gamma

1

1

High-throughput

0.479

High

827731

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

1

2

Small-scale

0.479

High

827735

RACK1
Small ribosomal subunit protein RACK1

1

6

Small-scale

0.479

High

827736

UBC9
SUMO-conjugating enzyme UBC9

1

1

High-throughput

0.479

High

827739

RNF4
E3 ubiquitin-protein ligase RNF4

1

4

High-throughput

0.479

High

827745

MDM2
E3 ubiquitin-protein ligase Mdm2

1

1

Small-scale

0.479

High

827747

IFM3
Interferon-induced transmembrane protein 3

1

4

Small-scale

0.479

High

827751

K1C17
Keratin, type I cytoskeletal 17

1

1

High-throughput

0.479

High

827762

FOXC1
Forkhead box protein C1

1

2

High-throughput

0.479

High

827765

TRI32
E3 ubiquitin-protein ligase TRIM32

1

6

Small-scale

0.479

High

827773

CUL3
Cullin-3

1

4

High-throughput

0.479

High

827774

CUL4A
Cullin-4A

1

4

High-throughput

0.479

High

827775

RUNX2
Runt-related transcription factor 2

1

1

Small-scale

0.479

High

827793

PTPA
Serine/threonine-protein phosphatase 2A activator

1

1

Small-scale

0.479

High

827798

SMAD1
Mothers against decapentaplegic homolog 1

1

2

Small-scale

0.479

High

827805

IF16
Gamma-interferon-inducible protein 16

1

1

Small-scale

0.479

High

827806

MICB
MHC class I polypeptide-related sequence B

1

1

Small-scale

0.479

High

827828

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

7

High-throughput

0.479

High

827830

NAA40
N-alpha-acetyltransferase 40

1

1

High-throughput

0.479

High

827837

Z3H7A
Zinc finger CCCH domain-containing protein 7A

1

1

High-throughput

0.479

High

827847

ARFG1
ADP-ribosylation factor GTPase-activating protein 1

1

1

High-throughput

0.479

High

827852

MAFA
Transcription factor MafA

1

3

Small-scale

0.479

High

827853

COP1
E3 ubiquitin-protein ligase COP1

1

5

Small-scale

0.479

High

827858

RBCC1
RB1-inducible coiled-coil protein 1

1

5

High-throughput

0.479

High

827865

GBF1
Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1

1

1

High-throughput

0.479

High

827866

TOPB1
DNA topoisomerase 2-binding protein 1

1

2

High-throughput

0.479

High

827871

ESR2
Estrogen receptor beta

1

19

High-throughput

0.479

High

827872

HDAC2
Histone deacetylase 2

1

11

Small-scale

0.479

High

827874

KAT2A
Histone acetyltransferase KAT2A

1

13

Small-scale

0.479

High

827875

KAT2B
Histone acetyltransferase KAT2B

1

8

Small-scale

0.479

High

827876

RAD50
DNA repair protein RAD50

1

1

High-throughput

0.479

High

827877

CSN5
COP9 signalosome complex subunit 5

1

3

Small-scale

0.479

High

827878

KAT5
Histone acetyltransferase KAT5

1

1

Small-scale

0.479

High

827883

SH3K1
SH3 domain-containing kinase-binding protein 1

1

1

High-throughput

0.479

High

827886

OPTN
Optineurin

1

3

High-throughput

0.479

High

827890

TRI11
E3 ubiquitin-protein ligase TRIM11

1

4

Small-scale

0.479

High

827895

SNX27
Sorting nexin-27

1

2

High-throughput

0.479

High

827914

HDAC8
Histone deacetylase 8

1

12

Small-scale

0.479

High

827916

HOIL1
RanBP-type and C3HC4-type zinc finger-containing protein 1

1

1

High-throughput

0.479

High

827920

WWTR1
WW domain-containing transcription regulator protein 1

1

7

High-throughput

0.479

High

827922

ATG5
Autophagy protein 5

1

1

High-throughput

0.479

High

827925

PKHA4
Pleckstrin homology domain-containing family A member 4

1

4

High-throughput

0.479

High

827929

TRI45
E3 ubiquitin-protein ligase TRIM45

1

16

Small-scale

0.479

High

827930

IL21
Interleukin-21

1

3

Small-scale

0.479

High

827932

IL1AP
Interleukin-1 receptor accessory protein

1

7

Small-scale

0.479

High

827950

SYLC
Leucine--tRNA ligase, cytoplasmic

1

1

High-throughput

0.479

High

827952

MAGC2
Melanoma-associated antigen C2

1

2

Small-scale

0.479

High

827953

HDAC6
Protein deacetylase HDAC6

1

12

Small-scale

0.479

High

827956

ZRAN1
Ubiquitin thioesterase ZRANB1

1

8

High-throughput

0.479

High

827957

TES
Testin

1

4

High-throughput

0.479

High

827959

XPO7
Exportin-7

1

2

High-throughput

0.479

High

827966

UBP22
Ubiquitin carboxyl-terminal hydrolase 22

1

5

Small-scale

0.479

High

717039

ECHM
Enoyl-CoA hydratase, mitochondrial

1

2

Small-scale

0.462

High

221321

SPY1
Protein sprouty homolog 1

1

0

High-throughput

0.460

High

239016

ZNRD2
Protein ZNRD2

1

0

High-throughput

0.460

High

409295

HLAA
HLA class I histocompatibility antigen, A alpha chain

1

0

High-throughput

0.460

High

827718

ARFP2
Arfaptin-2

1

0

High-throughput

0.460

High

827732

RL11
Large ribosomal subunit protein uL5

1

0

High-throughput

0.460

High

827839

ASXL1
Polycomb group protein ASXL1

1

0

High-throughput

0.460

High

827851

SP20H
Transcription factor SPT20 homolog

1

0

High-throughput

0.460

High

827863

FOG2
Zinc finger protein ZFPM2

1

0

High-throughput

0.460

High

827904

SCAFB
Protein SCAF11

1

0

High-throughput

0.460

High

827913

SRRT
Serrate RNA effector molecule homolog

1

0

High-throughput

0.460

High

827919

NIF3L
NIF3-like protein 1

1

0

High-throughput

0.460

High

131349

EIF3F
Eukaryotic translation initiation factor 3 subunit F

1

0

Small-scale

0.458

High

158136

COPE
Coatomer subunit epsilon

1

0

High-throughput

0.458

High

178205

NPC1
NPC intracellular cholesterol transporter 1

1

0

High-throughput

0.458

High

303436

SRP72
Signal recognition particle subunit SRP72

1

0

High-throughput

0.458

High

326998

NXPH2
Neurexophilin-2

1

0

High-throughput

0.458

High

340995

DIRA3
GTP-binding protein Di-Ras3

1

0

Small-scale

0.458

High

449507

LIPL
Lipoprotein lipase

1

0

Small-scale

0.458

High

515774

RGPD1
RANBP2-like and GRIP domain-containing protein 1

1

0

High-throughput

0.458

High

528208

THIO
Thioredoxin

1

0

Small-scale

0.458

High

573020

KPYM
Pyruvate kinase PKM

1

0

Small-scale

0.458

High

591241

CD44
CD44 antigen

1

0

Small-scale

0.458

High

593040

CREB1
Cyclic AMP-responsive element-binding protein 1

1

0

Small-scale

0.458

High

659985

COF1
Cofilin-1

1

0

High-throughput

0.458

High

718082

2AAB
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform

1

0

Small-scale

0.458

High

731037

STIP1
Stress-induced-phosphoprotein 1

1

0

High-throughput

0.458

High

766264

PHB1
Prohibitin 1

1

0

Small-scale

0.458

High

822496

VHL
von Hippel-Lindau disease tumor suppressor

1

0

Small-scale

0.458

High

827704

ENTP1
Ectonucleoside triphosphate diphosphohydrolase 1

1

0

Small-scale

0.458

High

827719

COPB
Coatomer subunit beta

1

0

High-throughput

0.458

High

827726

SIK1
Serine/threonine-protein kinase SIK1

1

0

Small-scale

0.458

High

827730

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.458

High

827769

PIN1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

1

0

Small-scale

0.458

High

827770

4EBP1
Eukaryotic translation initiation factor 4E-binding protein 1

1

0

Small-scale

0.458

High

827778

FZD2
Frizzled-2

1

0

Small-scale

0.458

High

827782

ITPR3
Inositol 1,4,5-trisphosphate-gated calcium channel ITPR3

1

0

Small-scale

0.458

High

827790

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

0

High-throughput

0.458

High

827791

PMVK
Phosphomevalonate kinase

1

0

High-throughput

0.458

High

827800

ZFHX3
Zinc finger homeobox protein 3

1

0

Small-scale

0.458

High

827810

MARH8
E3 ubiquitin-protein ligase MARCHF8

1

0

Small-scale

0.458

High

827813

RNLS
Renalase

1

0

Small-scale

0.458

High

827816

VIR
Protein virilizer homolog

1

0

High-throughput

0.458

High

827821

CTR9
RNA polymerase-associated protein CTR9 homolog

1

0

Small-scale

0.458

High

827824

TPGS1
Tubulin polyglutamylase complex subunit 1

1

0

High-throughput

0.458

High

827826

MOB3C
MOB kinase activator 3C

1

0

High-throughput

0.458

High

827835

LRC49
Leucine-rich repeat-containing protein 49

1

0

High-throughput

0.458

High

827845

RFLB
Refilin-B

1

0

High-throughput

0.458

High

827855

GSDMB
Gasdermin-B

1

0

Small-scale

0.458

High

827923

CHM4B
Charged multivesicular body protein 4b

1

0

High-throughput

0.458

High

827924

GOLP3
Golgi phosphoprotein 3

1

0

Small-scale

0.458

High

827927

HAUS4
HAUS augmin-like complex subunit 4

1

0

High-throughput

0.458

High

827944

PIHD1
PIH1 domain-containing protein 1

1

0

High-throughput

0.458

High

827947

TLS1
Splicing factor C9orf78

1

0

High-throughput

0.458

High

359939

NB5R3
NADH-cytochrome b5 reductase 3

1

4

High-throughput

0.445

High

529258

TAU
Microtubule-associated protein tau

1

1

High-throughput

0.445

High

540994

PIM1
Serine/threonine-protein kinase pim-1

1

2

Small-scale

0.445

High

595336

H15
Histone H1.5

1

1

High-throughput

0.445

High

827746

E2F1
Transcription factor E2F1

1

1

High-throughput

0.445

High

827764

STK4
Serine/threonine-protein kinase 4

1

2

High-throughput

0.445

High

827783

PLSI
Plastin-1

1

6

High-throughput

0.445

High

827814

A16L1
Autophagy-related protein 16-1

1

7

High-throughput

0.445

High

827833

STING
Stimulator of interferon genes protein

1

4

Small-scale

0.445

High

827840

TRI22
E3 ubiquitin-protein ligase TRIM22

1

4

High-throughput

0.445

High

827869

LPAR1
Lysophosphatidic acid receptor 1

1

4

High-throughput

0.445

High

827898

NUDC1
NudC domain-containing protein 1

1

1

High-throughput

0.445

High

827903

CDC5L
Cell division cycle 5-like protein

1

1

High-throughput

0.445

High

827917

ZDHC5
Palmitoyltransferase ZDHHC5

1

2

High-throughput

0.445

High

827967

TBD2B
TBC1 domain family member 2B

1

4

High-throughput

0.445

High

827857

MIPT3
TRAF3-interacting protein 1

1

0

High-throughput

0.438

High

105490

APRIO
Alternative prion protein

1

1

High-throughput

0.437

High

827788

HERP1
Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein

1

1

High-throughput

0.437

High

827809

OCAD2
OCIA domain-containing protein 2

1

1

Small-scale

0.437

High

827946

OCAD1
OCIA domain-containing protein 1

1

1

Small-scale

0.437

High

131145

CLIC1
Chloride intracellular channel protein 1

1

0

High-throughput

0.426

High

166260

ZNT4
Probable proton-coupled zinc antiporter SLC30A4

1

0

High-throughput

0.426

High

261115

NSMA
Sphingomyelin phosphodiesterase 2

1

0

High-throughput

0.426

High

280026

RM33
Large ribosomal subunit protein bL33m

1

0

High-throughput

0.426

High

330067

VENTX
Homeobox protein VENTX

1

0

High-throughput

0.426

High

455714

H10
Histone H1.0

1

0

High-throughput

0.426

High

563355

CFTR
Cystic fibrosis transmembrane conductance regulator

1

0

High-throughput

0.426

High

827754

VMAT2
Synaptic vesicular amine transporter

1

0

High-throughput

0.426

High

827768

RM49
Large ribosomal subunit protein mL49

1

0

High-throughput

0.426

High

827784

KCTD2
BTB/POZ domain-containing protein KCTD2

1

0

High-throughput

0.426

High

827789

SUZ12
Polycomb protein SUZ12

1

0

Small-scale

0.426

High

827803

FSCN1
Fascin

1

0

High-throughput

0.426

High

827868

SL9A6
Sodium/hydrogen exchanger 6

1

0

High-throughput

0.426

High

827905

S29A1
Equilibrative nucleoside transporter 1

1

0

High-throughput

0.426

High

827907

TMM43
Transmembrane protein 43

1

0

High-throughput

0.426

High

827926

VIAAT
Vesicular inhibitory amino acid transporter

1

0

High-throughput

0.426

High

827862

ZDH19
Palmitoyltransferase ZDHHC19

1

2

Small-scale

0.407

High

827820

F117B
Protein FAM117B

2

0

High-throughput

0.310

High

325298

OR2A4
Olfactory receptor 2A4

1

0

High-throughput

0.279

Low

827702

COMP
Cartilage oligomeric matrix protein

1

0

High-throughput

0.279

Low

827807

CR021
UPF0711 protein C18orf21

1

0

High-throughput

0.279

Low

827822

DLK2
Protein delta homolog 2

1

0

High-throughput

0.279

Low

827880

PIGT
GPI-anchor transamidase component PIGT

1

0

High-throughput

0.279

Low

827884

SARAF
Store-operated calcium entry-associated regulatory factor

1

0

High-throughput

0.279

Low

827906

PLCA
1-acyl-sn-glycerol-3-phosphate acyltransferase alpha

1

0

High-throughput

0.279

Low

827723

LAMB2
Laminin subunit beta-2

1

0

High-throughput

0.251

Low

827911

TMUB1
Transmembrane and ubiquitin-like domain-containing protein 1

1

0

Small-scale

0.249

Low

827970

AAR2
Protein AAR2 homolog

1

0

High-throughput

0.249

Low

827843

OFCC1
Orofacial cleft 1 candidate gene 1 protein

1

0

High-throughput

0.238

Low

827819

AR26L
Putative ankyrin repeat domain-containing protein 26-like protein

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025