HitPredict

Interactor 1: H3 (P07041)
Histone H3
Gene: hh3

Interactor 2: DIM5 (Q8X225)
Histone-lysine N-methyltransferase, H3 lysine-9 specific dim-5 (EC 2.1.1.355) (Histone H3-K9 methyltransferase dim-5) (H3-K9-HMTase dim-5) (HKMT)
Gene: dim-5

Species: Neurospora crassa OR74A

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	12887903
Identification Methods	enzymatic study
Interaction Type	enzymatic reaction

Property	Details
Interacting Pfam domains	Histone~SET
Common GO terms	GO:0005634 - nucleus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 136 Nc			1 331
+	Hs
		935251 H31_HUMAN (1-136): 1.69e-60: 184: 89.71		EHMT1_HUMAN (14-327): 1.99e-89: 293: 25.40
+	Hs
		952633 H33_HUMAN (1-136): 3.49e-60: 183: 91.18		EHMT1_HUMAN (14-327): 1.99e-89: 293: 25.40
+	Mm
		952777 H33_MOUSE (1-136): 3.49e-60: 183: 91.18		EHMT2_MOUSE (23-327): 2.03e-87: 287: 26.89
+	Hs
		935126 H31_HUMAN (1-136): 1.69e-60: 184: 89.71		EHMT2_HUMAN (22-327): 1.47e-86: 284: 26.80
+	Hs
		952553 H33_HUMAN (1-136): 3.49e-60: 183: 91.18		EHMT2_HUMAN (22-327): 1.47e-86: 284: 26.80
+	Hs
		935237 H31_HUMAN (1-136): 1.69e-60: 184: 89.71		SUV92_HUMAN (4-330): 9.6e-89: 273: 30.51
+	Hs
		952627 H33_HUMAN (1-136): 3.49e-60: 183: 91.18		SUV92_HUMAN (4-330): 9.6e-89: 273: 30.51
+	At
		886462 H33_ARATH (1-136): 1.41e-60: 184: 88.24		SUVH4_ARATH (1-331): 6.67e-85: 269: 20.61
+	Hs
		203659 H31_HUMAN (1-136): 1.69e-60: 184: 89.71		SUV91_HUMAN (7-331): 6e-87: 268: 29.59
+	Hs
		203664 H33_HUMAN (1-136): 3.49e-60: 183: 91.18		SUV91_HUMAN (7-331): 6e-87: 268: 29.59
+	Hs
		203722 H32_HUMAN (1-136): 2.65e-59: 181: 89.71		SUV91_HUMAN (7-331): 6e-87: 268: 29.59
+	Hs
		935204 H31_HUMAN (1-136): 1.69e-60: 184: 89.71		SETD2_HUMAN (3-330): 8.8e-76: 255: 19.82
+	Hs
		935276 H31_HUMAN (1-136): 1.69e-60: 184: 89.71		ASH1L_HUMAN (96-330): 5.4e-59: 206: 26.36
+	Hs
		952649 H33_HUMAN (1-136): 3.49e-60: 183: 91.18		ASH1L_HUMAN (96-330): 5.4e-59: 206: 26.36
+	Hs
		935129 H31_HUMAN (1-136): 1.69e-60: 184: 89.71		NSD1_HUMAN (138-330): 6.05e-19: 90.1: 33.50
+	Hs
		952555 H33_HUMAN (1-136): 3.49e-60: 183: 91.18		NSD1_HUMAN (138-330): 6.05e-19: 90.1: 33.50
+	Hs
		331780 H31_HUMAN (1-136): 1.69e-60: 184: 89.71		NSD2_HUMAN (138-330): 4.78e-18: 87: 30.93
+	Hs
		331787 H33_HUMAN (1-136): 3.49e-60: 183: 91.18		NSD2_HUMAN (138-330): 4.78e-18: 87: 30.93
+	Hs
		935205 H31_HUMAN (1-136): 1.69e-60: 184: 89.71		NSD3_HUMAN (129-330): 4.55e-17: 84.3: 31.53
+	Hs
		952607 H33_HUMAN (1-136): 3.49e-60: 183: 91.18		NSD3_HUMAN (129-330): 4.55e-17: 84.3: 31.53