HitPredict

Interactor 1: KLK3 (P07288)
Prostate-specific antigen (PSA) (EC 3.4.21.77) (Gamma-seminoprotein) (Seminin) (Kallikrein-3) (P-30 antigen) (Semenogelase)
Gene: KLK3

Interactor 2: ANDR (P10275)
Androgen receptor (Dihydrotestosterone receptor) (Nuclear receptor subfamily 3 group C member 4)
Gene: AR

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.90	0.60	0.738

Property	Details
Experiments	14638683, 17011549, 17707232, 25682698, 25693204, 25728837, 19345326
Identification Methods	anti tag coimmunoprecipitation, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003073 - regulation of systemic arterial blood pressure GO:0005634 - nucleus GO:0032991 - protein-containing complex
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 261 Hs			1 920
+	Hs
		487120 KLK2_HUMAN (1-261): 1.16e-119: 344: 77.01		ANDR_HUMAN (1-920): 0: 966: 100.00
+	Hs
		370676 KLK9_HUMAN (22-259): 8.96e-97: 285: 39.50		ESR1_HUMAN (378-904): 7.6e-136: 420: 22.20
+	Hs
		370770 KLK5_HUMAN (8-260): 5.42e-94: 280: 40.00		ESR1_HUMAN (378-904): 7.6e-136: 420: 22.20
+	Hs
		369702 PRSS8_HUMAN (13-257): 1.16e-90: 273: 34.34		ESR1_HUMAN (378-904): 7.6e-136: 420: 22.20
+	Hs
		587148 TMPS3_HUMAN (7-259): 6.78e-96: 290: 30.83		RXRA_HUMAN (392-902): 7.05e-120: 374: 19.84
+	Hs
		1269896 KLK9_HUMAN (22-259): 8.96e-97: 285: 39.50		ESR2_HUMAN (435-912): 2.48e-116: 367: 21.51
+	Hs
		1085212 PRSS8_HUMAN (13-257): 1.16e-90: 273: 34.34		ESR2_HUMAN (435-912): 2.48e-116: 367: 21.51
+	Hs
		622835 TMPS5_HUMAN (8-256): 1.96e-90: 276: 34.22		COT2_HUMAN (492-900): 2.13e-109: 345: 19.07
+	Hs
		377056 GRAA_HUMAN (21-257): 2.09e-40: 142: 35.77		GCR_HUMAN (444-920): 1.2e-117: 378: 40.85