HitPredict

Interactor 1: CRGC (P07315)
Gamma-crystallin C (Gamma-C-crystallin) (Gamma-crystallin 2-1) (Gamma-crystallin 3)
Gene: CRYGC

Interactor 2: CRGB (P07316)
Gamma-crystallin B (Gamma-B-crystallin) (Gamma-crystallin 1-2)
Gene: CRYGB

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.71	1.00	0.848

Property	Details
Experiments	26186194, 28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Crystall~Crystall
Common GO terms	GO:0002088 - lens development in camera-type eye GO:0005212 - structural constituent of eye lens GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0007601 - visual perception
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 174 Hs			1 175
+	Hs
		426902 CRGC_HUMAN (1-174): 1e-95: 276: 100.00		CRGC_HUMAN (1-175): 1.52e-93: 270: 78.86
+	Hs
		426904 CRGC_HUMAN (1-174): 1e-95: 276: 100.00		CRGD_HUMAN (1-174): 8.63e-88: 256: 72.41
+	Hs
		426911 CRGD_HUMAN (1-173): 1.65e-88: 258: 71.68		CRGD_HUMAN (1-174): 8.63e-88: 256: 72.41
+	Hs
		863882 CRBA4_HUMAN (3-172): 2.14e-68: 207: 34.78		CRBA4_HUMAN (3-173): 5.39e-69: 209: 32.61
+	Hs
		426906 CRGC_HUMAN (1-174): 1e-95: 276: 100.00		CRBB2_HUMAN (83-171): 1.45e-19: 83.4: 26.37
+	Hs
		409341 CRBA1_HUMAN (3-172): 6.68e-71: 215: 34.24		CRBB1_HUMAN (75-171): 1.7e-22: 91.9: 26.26
+	Hs
		409337 CRBA1_HUMAN (3-172): 6.68e-71: 215: 34.24		CRBA1_HUMAN (73-171): 3.08e-22: 90.7: 30.10
+	Hs
		863883 CRBA4_HUMAN (3-172): 2.14e-68: 207: 34.78		CRBB1_HUMAN (75-171): 1.7e-22: 91.9: 26.26
+	Hs
		409340 CRBA1_HUMAN (3-172): 6.68e-71: 215: 34.24		CRBB2_HUMAN (83-171): 1.45e-19: 83.4: 26.37
+	Hs
		409338 CRBA1_HUMAN (3-172): 6.68e-71: 215: 34.24		CRBB3_HUMAN (86-171): 1.98e-18: 80.3: 29.55
+	Hs
		795391 CRBA4_HUMAN (3-172): 2.14e-68: 207: 34.78		CRBB2_HUMAN (83-171): 1.45e-19: 83.4: 26.37
+	Hs
		795389 CRBB2_HUMAN (3-97): 4.88e-19: 81.8: 30.61		CRBB2_HUMAN (83-171): 1.45e-19: 83.4: 26.37
+	Hs
		795390 CRBB2_HUMAN (3-97): 4.88e-19: 81.8: 30.61		CRBA2_HUMAN (3-83): 5.69e-13: 65.7: 27.78
+	Hs
		863856 CRBB1_HUMAN (3-88): 1.59e-18: 81.4: 28.09		CRBA2_HUMAN (3-83): 5.69e-13: 65.7: 27.78