HitPredict

Interactor 1: FES (P07332)
Tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (Feline sarcoma/Fujinami avian sarcoma oncogene homolog) (Proto-oncogene c-Fes) (Proto-oncogene c-Fps) (p93c-fes)
Gene: FES

Interactor 2: FKBP5 (Q13451)
Peptidyl-prolyl cis-trans isomerase FKBP5 (PPIase FKBP5) (EC 5.2.1.8) (51 kDa FK506-binding protein) (51 kDa FKBP) (FKBP-51) (54 kDa progesterone receptor-associated immunophilin) (Androgen-regulated protein 6) (FF1 antigen) (FK506-binding protein 5) (FKBP-5) (FKBP54) (p54) (HSP90-binding immunophilin) (Rotamase)
Gene: FKBP5

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	9222609
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	FKBP_C~PK_Tyr_Ser-Thr
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 822 Hs			1 457
+	Hs
		561387 FER_HUMAN (1-820): 0: 874: 50.30		FKBP5_HUMAN (1-457): 6.63e-145: 423: 100.00
+	Hs
		426954 FES_HUMAN (1-822): 0: 838: 100.00		FKBP4_HUMAN (1-456): 1.79e-136: 402: 54.59
+	Hs
		118687 FER_HUMAN (1-820): 0: 874: 50.30		AIP_HUMAN (144-414): 1.52e-49: 173: 16.72
+	Hs
		426955 FES_HUMAN (1-822): 0: 838: 100.00		PPID_HUMAN (249-414): 4.11e-51: 178: 24.55
+	Hs
		454829 FGR_HUMAN (399-816): 3.46e-159: 475: 31.83		FKBP5_HUMAN (1-457): 6.63e-145: 423: 100.00
+	Hs
		846467 BLK_HUMAN (365-818): 4.82e-159: 474: 30.72		FKBP5_HUMAN (1-457): 6.63e-145: 423: 100.00
+	Hs
		1034994 SRMS_HUMAN (393-821): 3.7e-151: 453: 34.08		FKBP5_HUMAN (1-457): 6.63e-145: 423: 100.00
+	Hs
		411681 LCK_HUMAN (382-817): 1.65e-152: 457: 31.82		FKBP4_HUMAN (1-456): 1.79e-136: 402: 54.59
+	Hs
		118679 FGR_HUMAN (399-816): 3.46e-159: 475: 31.83		AIP_HUMAN (144-414): 1.52e-49: 173: 16.72
+	Hs
		118710 BLK_HUMAN (365-818): 4.82e-159: 474: 30.72		AIP_HUMAN (144-414): 1.52e-49: 173: 16.72
+	Hs
		118675 YES_HUMAN (399-816): 2.3e-154: 464: 33.41		AIP_HUMAN (144-414): 1.52e-49: 173: 16.72
+	Hs
		411693 LCK_HUMAN (382-817): 1.65e-152: 457: 31.82		PPID_HUMAN (249-414): 4.11e-51: 178: 24.55
+	Hs
		118670 LCK_HUMAN (382-817): 1.65e-152: 457: 31.82		AIP_HUMAN (144-414): 1.52e-49: 173: 16.72
+	Hs
		118671 FYN_HUMAN (399-816): 2.27e-151: 455: 32.96		AIP_HUMAN (144-414): 1.52e-49: 173: 16.72
+	Hs
		118683 SRC_HUMAN (323-816): 2.27e-147: 445: 30.62		AIP_HUMAN (144-414): 1.52e-49: 173: 16.72
+	Hs
		411617 LCK_HUMAN (382-817): 1.65e-152: 457: 31.82		STIP1_HUMAN (265-457): 3.91e-23: 104: 17.62
+	Hs
		684476 CSK_HUMAN (401-821): 2.97e-146: 439: 33.26		STIP1_HUMAN (265-457): 3.91e-23: 104: 17.62