HitPredict

Interactor 1: CSF1R (P07333)
Macrophage colony-stimulating factor 1 receptor (CSF-1 receptor) (CSF-1-R) (CSF-1R) (M-CSF-R) (EC 2.7.10.1) (Proto-oncogene c-Fms) (CD antigen CD115)
Gene: CSF1R

Interactor 2: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.71 1.00 0.843

The method score is based on:

Property Details
Experiments 7597091, 9380408, 10025673
Identification Methods affinity chromatography technology, two hybrid, pull down
Interaction Type physical association, direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains PK_Tyr_Ser-Thr~SH2, PK_Tyr_Ser-Thr~SH3_1
Common GO terms GO:0005654 - nucleoplasm
GO:0005886 - plasma membrane
GO:0007165 - signal transduction
GO:0019903 - protein phosphatase binding
GO:0043408 - regulation of MAPK cascade
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 972
Hs

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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024