HitPredict

Interactor 1: CAN1 (P07384)
Calpain-1 catalytic subunit (EC 3.4.22.52) (Calcium-activated neutral proteinase 1) (CANP 1) (Calpain mu-type) (Calpain-1 large subunit) (Cell proliferation-inducing gene 30 protein) (Micromolar-calpain) (muCANP)
Gene: CAPN1

Interactor 2: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.585

Property	Details
Experiments	22535953, 35063084
Identification Methods	enzymatic study, anti tag coimmunoprecipitation
Interaction Type	direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005576 - extracellular region GO:0005737 - cytoplasm GO:0005739 - mitochondrion GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 714 Hs			1 758
+	Hs
		496249 CAN2_HUMAN (13-710): 0: 917: 62.75		TAU_HUMAN (1-758): 3.6e-89: 298: 100.00
+	Hs
		427847 CAN1_HUMAN (1-714): 0: 950: 100.00		MAP4_HUMAN (3-742): 6.73e-32: 135: 20.56
+	Hs
		496397 SORCN_HUMAN (540-712): 5.06e-63: 210: 31.21		TAU_HUMAN (1-758): 3.6e-89: 298: 100.00
+	Hs
		385829 CPNS1_HUMAN (510-714): 2.62e-56: 194: 43.60		TAU_HUMAN (1-758): 3.6e-89: 298: 100.00
+	Hs
		497616 CAN10_HUMAN (362-527): 4.78e-12: 71.2: 25.15		TAU_HUMAN (1-758): 3.6e-89: 298: 100.00
+	Hs
		385842 CPNS1_HUMAN (510-714): 2.62e-56: 194: 43.60		MAP4_HUMAN (3-742): 6.73e-32: 135: 20.56
+	Bt
		664290 CALM_BOVIN (532-617): 5.54e-14: 71.6: 20.69		TAU_BOVIN (1-291): 3.66e-12: 71.3: 40.00