Protein: ICAM1
Intercellular adhesion molecule 1 (ICAM-1) (Major group rhinovirus receptor) (CD antigen CD54)

Gene: ICAM1
Organism: Homo sapiens
Interactions: 225
UniProt ID: P05362

Gene Ontology (top 5):
GO:0001618 - virus receptor activity
GO:0001772 - immunological synapse
GO:0001910 - regulation of leukocyte mediated cytotoxicity
GO:0002291 - T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell
GO:0002457 - T cell antigen processing and presentation

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

427801

ITAL
Integrin alpha-L

5

7

Small-scale

0.920

High

424049

ITB2
Integrin beta-2

5

6

Small-scale

0.710

High

427867

TBA4A
Tubulin alpha-4A chain

3

9

High-throughput

0.667

High

427782

ITAM
Integrin alpha-M

1

7

Small-scale

0.647

High

427790

AREG
Amphiregulin

3

0

High-throughput

0.638

High

427946

TNR27
Tumor necrosis factor receptor superfamily member 27

3

0

High-throughput

0.638

High

231670

PEX1
Peroxisomal ATPase PEX1

2

2

High-throughput

0.628

High

427887

PAK1
Serine/threonine-protein kinase PAK 1

2

3

High-throughput

0.628

High

427888

PAK2
Serine/threonine-protein kinase PAK 2

2

3

High-throughput

0.628

High

427895

ARHG7
Rho guanine nucleotide exchange factor 7

2

3

High-throughput

0.628

High

427896

GIT2
ARF GTPase-activating protein GIT2

2

8

High-throughput

0.628

High

427914

WDFY3
WD repeat and FYVE domain-containing protein 3

2

2

High-throughput

0.628

High

427962

GIT1
ARF GTPase-activating protein GIT1

2

9

High-throughput

0.628

High

362584

EGFR
Epidermal growth factor receptor

2

14

Small-scale

0.621

High

427816

BASI
Basigin

1

16

High-throughput

0.618

High

427826

MUC18
Cell surface glycoprotein MUC18

1

19

High-throughput

0.618

High

70082

CRTP1
Cysteine-rich tail protein 1

2

1

High-throughput

0.606

High

427953

UBQL2
Ubiquilin-2

2

6

High-throughput

0.606

High

303056

CCN5
CCN family member 5

2

0

High-throughput

0.602

High

427844

NCS1
Neuronal calcium sensor 1

2

0

High-throughput

0.602

High

427800

NFKB1
Nuclear factor NF-kappa-B p105 subunit

3

13

Small-scale

0.585

High

427880

TF65
Transcription factor p65

3

5

Small-scale

0.585

High

251338

CIDEA
Lipid transferase CIDEA

2

1

High-throughput

0.574

High

427886

FOXF1
Forkhead box protein F1

2

2

High-throughput

0.574

High

427898

ARHG6
Rho guanine nucleotide exchange factor 6

2

3

High-throughput

0.574

High

427789

EZRI
Ezrin

1

20

Small-scale

0.561

High

427837

KR108
Keratin-associated protein 10-8

2

2

High-throughput

0.553

High

427893

KEAP1
Kelch-like ECH-associated protein 1

2

4

High-throughput

0.553

High

212922

HS12A
Heat shock 70 kDa protein 12A

1

1

High-throughput

0.536

High

407955

TBB4A
Tubulin beta-4A chain

1

13

High-throughput

0.536

High

427787

CFTR
Cystic fibrosis transmembrane conductance regulator

1

2

High-throughput

0.536

High

427877

NAAA
N-acylethanolamine-hydrolyzing acid amidase

1

1

High-throughput

0.536

High

427882

TWF1
Twinfilin-1

1

1

High-throughput

0.536

High

427883

HYAL1
Hyaluronidase-1

1

1

High-throughput

0.536

High

427891

TBB3
Tubulin beta-3 chain

1

13

High-throughput

0.536

High

427901

TBB8
Tubulin beta-8 chain

1

14

High-throughput

0.536

High

427909

TBA1A
Tubulin alpha-1A chain

1

10

High-throughput

0.536

High

427917

AQP3
Aquaporin-3

1

2

High-throughput

0.536

High

427928

GML
Glycosyl-phosphatidylinositol-anchored molecule-like protein

1

2

High-throughput

0.536

High

427943

ADAM7
Disintegrin and metalloproteinase domain-containing protein 7

1

3

High-throughput

0.536

High

427944

TMPS5
Transmembrane protease serine 5

1

1

High-throughput

0.536

High

427965

GPR45
Probable G-protein coupled receptor 45

1

9

High-throughput

0.536

High

427966

CLIC4
Chloride intracellular channel protein 4

1

1

High-throughput

0.536

High

427967

BIG2
Brefeldin A-inhibited guanine nucleotide-exchange protein 2

1

1

High-throughput

0.536

High

427930

CIB1
Calcium and integrin-binding protein 1

1

1

High-throughput

0.515

High

378404

IFNG
Interferon gamma

1

0

High-throughput

0.513

High

427795

AATC
Aspartate aminotransferase, cytoplasmic

1

0

High-throughput

0.513

High

427916

ITLN1
Intelectin-1

1

0

High-throughput

0.513

High

427957

A4GCT
Alpha-1,4-N-acetylglucosaminyltransferase

1

0

High-throughput

0.513

High

174209

ARHGA
Rho guanine nucleotide exchange factor 10

1

4

High-throughput

0.489

High

288214

KBL
2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial

1

2

High-throughput

0.489

High

427817

AHR
Aryl hydrocarbon receptor

1

1

High-throughput

0.489

High

427830

DNSL1
Deoxyribonuclease-1-like 1

1

1

High-throughput

0.489

High

427913

NNRD
ATP-dependent

1

1

High-throughput

0.489

High

427918

AP3S1
AP-3 complex subunit sigma-1

1

2

High-throughput

0.489

High

427923

TTC28
Tetratricopeptide repeat protein 28

1

2

High-throughput

0.489

High

427925

SGK3
Serine/threonine-protein kinase Sgk3

1

1

High-throughput

0.489

High

427926

DHTK1
2-oxoadipate dehydrogenase complex component E1

1

1

High-throughput

0.489

High

427941

CST11
Cystatin-11

1

2

High-throughput

0.489

High

427945

GHC1
Mitochondrial glutamate carrier 1

1

1

High-throughput

0.489

High

427954

RSP14
Radial spoke head 14 homolog

1

1

High-throughput

0.489

High

131287

EIF3F
Eukaryotic translation initiation factor 3 subunit F

1

1

High-throughput

0.479

High

141279

DDX3X
ATP-dependent RNA helicase DDX3X

1

5

High-throughput

0.479

High

187858

EIF3H
Eukaryotic translation initiation factor 3 subunit H

1

3

High-throughput

0.479

High

224583

ACTN4
Alpha-actinin-4

1

10

High-throughput

0.479

High

250411

HNRPQ
Heterogeneous nuclear ribonucleoprotein Q

1

7

High-throughput

0.479

High

256735

H2B1K
Histone H2B type 1-K

1

20

High-throughput

0.479

High

400110

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

4

High-throughput

0.479

High

403730

GCR
Glucocorticoid receptor

1

11

Small-scale

0.479

High

408611

G3P
Glyceraldehyde-3-phosphate dehydrogenase

1

1

High-throughput

0.479

High

410516

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

12

High-throughput

0.479

High

427772

RLA0
Large ribosomal subunit protein uL10

1

2

High-throughput

0.479

High

427773

NPM
Nucleophosmin

1

2

High-throughput

0.479

High

427774

H2B1J
Histone H2B type 1-J

1

20

High-throughput

0.479

High

427775

TBB5
Tubulin beta chain

1

13

High-throughput

0.479

High

427777

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

18

High-throughput

0.479

High

427779

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

8

Small-scale

0.479

High

427781

MYH3
Myosin-3

1

4

High-throughput

0.479

High

427783

PABP1
Polyadenylate-binding protein 1

1

8

High-throughput

0.479

High

427784

ACTN1
Alpha-actinin-1

1

10

High-throughput

0.479

High

427785

XRCC6
X-ray repair cross-complementing protein 6

1

4

High-throughput

0.479

High

427786

XRCC5
X-ray repair cross-complementing protein 5

1

4

High-throughput

0.479

High

427791

RS2
Small ribosomal subunit protein uS5

1

1

High-throughput

0.479

High

427799

NUCL
Nucleolin

1

7

High-throughput

0.479

High

427802

FLNA
Filamin-A

1

15

High-throughput

0.479

High

427803

RS4Y1
Small ribosomal subunit protein eS4, Y isoform 1

1

2

High-throughput

0.479

High

427804

ROA2
Heterogeneous nuclear ribonucleoproteins A2/B1

1

17

High-throughput

0.479

High

427805

RS3
Small ribosomal subunit protein uS3

1

1

High-throughput

0.479

High

427807

MOES
Moesin

1

20

High-throughput

0.479

High

427808

RL13
Large ribosomal subunit protein eL13

1

1

High-throughput

0.479

High

427809

RL12
Large ribosomal subunit protein uL11

1

2

High-throughput

0.479

High

427810

HNRH1
Heterogeneous nuclear ribonucleoprotein H

1

16

High-throughput

0.479

High

427811

IL3RB
Cytokine receptor common subunit beta

1

7

Small-scale

0.479

High

427812

RL9
Large ribosomal subunit protein uL6

1

1

High-throughput

0.479

High

427815

RL22
Large ribosomal subunit protein eL22

1

1

High-throughput

0.479

High

427818

RL4
Large ribosomal subunit protein uL4

1

1

High-throughput

0.479

High

427820

RS19
Small ribosomal subunit protein eS19

1

1

High-throughput

0.479

High

427821

RL13A
Large ribosomal subunit protein uL13

1

2

High-throughput

0.479

High

427822

STAT3
Signal transducer and activator of transcription 3

1

3

Small-scale

0.479

High

427823

LAP2B
Lamina-associated polypeptide 2, isoforms beta/gamma

1

2

High-throughput

0.479

High

427825

RL35
Large ribosomal subunit protein uL29

1

1

High-throughput

0.479

High

427827

RL27A
Large ribosomal subunit protein uL15

1

1

High-throughput

0.479

High

427828

RL5
Large ribosomal subunit protein uL18

1

1

High-throughput

0.479

High

427829

RS9
Small ribosomal subunit protein uS4

1

1

High-throughput

0.479

High

427831

TCPG
T-complex protein 1 subunit gamma

1

6

High-throughput

0.479

High

427832

TCPD
T-complex protein 1 subunit delta

1

5

High-throughput

0.479

High

427834

EIF3B
Eukaryotic translation initiation factor 3 subunit B

1

2

High-throughput

0.479

High

427835

H2B1D
Histone H2B type 1-D

1

20

High-throughput

0.479

High

427836

EIF3E
Eukaryotic translation initiation factor 3 subunit E

1

1

High-throughput

0.479

High

427838

ACTB
Actin, cytoplasmic 1

1

3

High-throughput

0.479

High

427839

RS3A
Small ribosomal subunit protein eS1

1

1

High-throughput

0.479

High

427840

RL26
Large ribosomal subunit protein uL24

1

3

High-throughput

0.479

High

427841

RL27
Large ribosomal subunit protein eL27

1

1

High-throughput

0.479

High

427843

HNRPK
Heterogeneous nuclear ribonucleoprotein K

1

8

High-throughput

0.479

High

427845

RS8
Small ribosomal subunit protein eS8

1

1

High-throughput

0.479

High

427846

RS16
Small ribosomal subunit protein uS9

1

1

High-throughput

0.479

High

427847

RS14
Small ribosomal subunit protein uS11

1

1

High-throughput

0.479

High

427848

RS23
Small ribosomal subunit protein uS12

1

1

High-throughput

0.479

High

427849

RS18
Small ribosomal subunit protein uS13

1

1

High-throughput

0.479

High

427850

RS13
Small ribosomal subunit protein uS15

1

1

High-throughput

0.479

High

427854

RL7A
Large ribosomal subunit protein eL8

1

2

High-throughput

0.479

High

427855

RS4X
Small ribosomal subunit protein eS4, X isoform

1

2

High-throughput

0.479

High

427856

RL23A
Large ribosomal subunit protein uL23

1

1

High-throughput

0.479

High

427857

RS6
Small ribosomal subunit protein eS6

1

1

High-throughput

0.479

High

427858

H2B1C
Histone H2B type 1-C/E/F/G/I

1

20

High-throughput

0.479

High

427860

RS25
Small ribosomal subunit protein eS25

1

1

High-throughput

0.479

High

427861

RS28
Small ribosomal subunit protein eS28

1

1

High-throughput

0.479

High

427862

RL30
Large ribosomal subunit protein eL30

1

1

High-throughput

0.479

High

427863

RL31
Large ribosomal subunit protein eL31

1

1

High-throughput

0.479

High

427864

RL11
Large ribosomal subunit protein uL5

1

1

High-throughput

0.479

High

427865

RL8
Large ribosomal subunit protein uL2

1

1

High-throughput

0.479

High

427866

YBOX1
Y-box-binding protein 1

1

3

High-throughput

0.479

High

427868

CSK21
Casein kinase II subunit alpha

1

3

High-throughput

0.479

High

427869

H31
Histone H3.1

1

8

High-throughput

0.479

High

427870

RL24
Large ribosomal subunit protein eL24

1

2

High-throughput

0.479

High

427871

RL19
Large ribosomal subunit protein eL19

1

1

High-throughput

0.479

High

427872

SRSF3
Serine/arginine-rich splicing factor 3

1

12

High-throughput

0.479

High

427873

H33
Histone H3.3

1

8

High-throughput

0.479

High

427875

HNRPU
Heterogeneous nuclear ribonucleoprotein U

1

7

High-throughput

0.479

High

427878

H11
Histone H1.1

1

10

High-throughput

0.479

High

427879

RL6
Large ribosomal subunit protein eL6

1

1

High-throughput

0.479

High

427881

RL18
Large ribosomal subunit protein eL18

1

1

High-throughput

0.479

High

427884

ILF2
Interleukin enhancer-binding factor 2

1

3

High-throughput

0.479

High

427885

ILF3
Interleukin enhancer-binding factor 3

1

4

High-throughput

0.479

High

427889

EIF3I
Eukaryotic translation initiation factor 3 subunit I

1

6

High-throughput

0.479

High

427894

EIF3A
Eukaryotic translation initiation factor 3 subunit A

1

9

High-throughput

0.479

High

427899

IF16
Gamma-interferon-inducible protein 16

1

1

High-throughput

0.479

High

427900

H31T
Histone H3.1t

1

8

High-throughput

0.479

High

427902

H2B2F
Histone H2B type 2-F

1

20

High-throughput

0.479

High

427906

PRP8
Pre-mRNA-processing-splicing factor 8

1

1

High-throughput

0.479

High

427908

H32
Histone H3.2

1

8

High-throughput

0.479

High

427910

THOC4
THO complex subunit 4

1

7

High-throughput

0.479

High

427919

AN32B
Acidic leucine-rich nuclear phosphoprotein 32 family member B

1

6

High-throughput

0.479

High

427920

DDX17
Probable ATP-dependent RNA helicase DDX17

1

5

High-throughput

0.479

High

427921

H2B1H
Histone H2B type 1-H

1

20

High-throughput

0.479

High

427922

H2B1A
Histone H2B type 1-A

1

20

High-throughput

0.479

High

427931

H2B1N
Histone H2B type 1-N

1

20

High-throughput

0.479

High

427932

H2B1M
Histone H2B type 1-M

1

20

High-throughput

0.479

High

427933

H2B1L
Histone H2B type 1-L

1

20

High-throughput

0.479

High

427938

TBB6
Tubulin beta-6 chain

1

13

High-throughput

0.479

High

427949

EIF3K
Eukaryotic translation initiation factor 3 subunit K

1

1

High-throughput

0.479

High

427951

TES
Testin

1

3

High-throughput

0.479

High

427958

RL26L
Ribosomal protein uL24-like

1

3

High-throughput

0.479

High

427960

EIF3L
Eukaryotic translation initiation factor 3 subunit L

1

1

High-throughput

0.479

High

427963

RL36
Large ribosomal subunit protein eL36

1

1

High-throughput

0.479

High

427936

PELO
Protein pelota homolog

1

1

High-throughput

0.470

High

378601

IL2RA
Interleukin-2 receptor subunit alpha

1

0

Small-scale

0.458

High

427771

RLA2
Large ribosomal subunit protein P2

1

0

High-throughput

0.458

High

427776

4F2
Amino acid transporter heavy chain SLC3A2

1

0

Small-scale

0.458

High

427796

RL35A
Large ribosomal subunit protein eL33

1

0

High-throughput

0.458

High

427814

NOS2
Nitric oxide synthase, inducible

1

0

High-throughput

0.458

High

427859

RS15
Small ribosomal subunit protein uS19

1

0

High-throughput

0.458

High

427915

EMC1
ER membrane protein complex subunit 1

1

0

High-throughput

0.458

High

67152

TBB8B
Tubulin beta 8B

1

14

High-throughput

0.445

High

81667

EIFCL
Eukaryotic translation initiation factor 3 subunit C-like protein

1

2

High-throughput

0.437

High

105119

APRIO
Alternative prion protein

1

9

High-throughput

0.437

High

295073

EIF3G
Eukaryotic translation initiation factor 3 subunit G

1

7

High-throughput

0.437

High

427778

RU2A
U2 small nuclear ribonucleoprotein A'

1

4

High-throughput

0.437

High

427780

H14
Histone H1.4

1

10

High-throughput

0.437

High

427792

H13
Histone H1.3

1

10

High-throughput

0.437

High

427793

H12
Histone H1.2

1

10

High-throughput

0.437

High

427794

YBOX3
Y-box-binding protein 3

1

3

High-throughput

0.437

High

427798

RL17
Large ribosomal subunit protein uL22

1

1

High-throughput

0.437

High

427806

H2B1O
Histone H2B type 1-O

1

20

High-throughput

0.437

High

427813

H2B1B
Histone H2B type 1-B

1

20

High-throughput

0.437

High

427819

SRP14
Signal recognition particle 14 kDa protein

1

1

High-throughput

0.437

High

427824

STAT1
Signal transducer and activator of transcription 1-alpha/beta

1

3

Small-scale

0.437

High

427833

ROA3
Heterogeneous nuclear ribonucleoprotein A3

1

20

High-throughput

0.437

High

427842

WDR5
WD repeat-containing protein 5

1

3

High-throughput

0.437

High

427851

LSM3
U6 snRNA-associated Sm-like protein LSm3

1

3

High-throughput

0.437

High

427852

SMD1
Small nuclear ribonucleoprotein Sm D1

1

4

High-throughput

0.437

High

427853

SMD3
Small nuclear ribonucleoprotein Sm D3

1

4

High-throughput

0.437

High

427876

SET
Protein SET

1

1

High-throughput

0.437

High

427890

TCOF
Treacle protein

1

3

High-throughput

0.437

High

427892

HNRPD
Heterogeneous nuclear ribonucleoprotein D0

1

20

High-throughput

0.437

High

427897

SART3
Spliceosome associated factor 3, U4/U6 recycling protein

1

9

High-throughput

0.437

High

427907

TRI67
Tripartite motif-containing protein 67

1

12

High-throughput

0.437

High

427929

EIF3C
Eukaryotic translation initiation factor 3 subunit C

1

2

High-throughput

0.437

High

427947

ANLN
Anillin

1

1

High-throughput

0.437

High

427948

FBX6
F-box only protein 6

1

9

High-throughput

0.437

High

427950

ZRAN1
Ubiquitin thioesterase ZRANB1

1

5

High-throughput

0.437

High

427952

SEPT9
Septin-9

1

3

Small-scale

0.437

High

427955

TBE
Tubulin epsilon chain

1

15

High-throughput

0.437

High

427961

YBOX2
Y-box-binding protein 2

1

3

High-throughput

0.437

High

427797

ARY1
Arylamine N-acetyltransferase 1

3

0

High-throughput

0.342

High

427904

HEAT6
HEAT repeat-containing protein 6

2

0

High-throughput

0.328

High

427934

F118B
Protein FAM118B

2

0

High-throughput

0.328

High

427935

ZNG1A
Zinc-regulated GTPase metalloprotein activator 1A

2

0

High-throughput

0.328

High

427939

5NT1A
Cytosolic 5'-nucleotidase 1A

2

0

High-throughput

0.328

High

427911

NUD13
NAD(P)H pyrophosphatase NUDT13, mitochondrial

2

0

High-throughput

0.324

High

427942

3BHS7
3 beta-hydroxysteroid dehydrogenase type 7

1

0

High-throughput

0.282

High

67349

RTL8C
Retrotransposon Gag-like protein 8C

1

0

High-throughput

0.279

Low

292326

RA51D
DNA repair protein RAD51 homolog 4

1

0

High-throughput

0.279

Low

427905

MZT2B
Mitotic-spindle organizing protein 2B

1

0

High-throughput

0.279

Low

427924

OTUL
Ubiquitin thioesterase otulin

1

0

High-throughput

0.279

Low

427937

THTPA
Thiamine-triphosphatase

1

0

High-throughput

0.279

Low

427940

NMNA2
Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2

1

0

High-throughput

0.279

Low

427959

DHDH
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase

1

0

High-throughput

0.279

Low

427788

RSMB
Small nuclear ribonucleoprotein-associated proteins B and B'

1

0

High-throughput

0.249

Low

427874

PURA
Transcriptional activator protein Pur-alpha

1

0

High-throughput

0.249

Low

427903

VIR
Protein virilizer homolog

1

0

High-throughput

0.249

Low

427912

MARH9
E3 ubiquitin-protein ligase MARCHF9

1

0

Small-scale

0.249

Low

427956

FBX4
F-box only protein 4

1

0

Small-scale

0.249

Low

427964

SP16H
FACT complex subunit SPT16

1

0

High-throughput

0.249

Low

427927

AP4AT
AP-4 complex accessory subunit Tepsin

1

0

Small-scale

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025