HitPredict

Interactor 1: CAN1 (P07384)
Calpain-1 catalytic subunit (EC 3.4.22.52) (Calcium-activated neutral proteinase 1) (CANP 1) (Calpain mu-type) (Calpain-1 large subunit) (Cell proliferation-inducing gene 30 protein) (Micromolar-calpain) (muCANP)
Gene: CAPN1

Interactor 2: ICAL (P20810)
Calpastatin (Calpain inhibitor) (Sperm BS-17 component)
Gene: CAST

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.85	1.00	0.925

Property	Details
Experiments	12684003, 26496610, 28514442, 33961781, 20679491
Identification Methods	x-ray crystallography, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	association, physical association

Property	Details
Interacting Pfam domains	Calpain_III~Calpain_inhib, Calpain_inhib~EF-hand_8, Calpain_inhib~Peptidase_C2
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0016020 - membrane
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 714 Hs			1 708
+	Hs
		568946 CAN2_HUMAN (13-710): 0: 917: 62.75		ICAL_HUMAN (1-708): 1.39e-102: 331: 100.00
+	Hs
		62712 CAN8_HUMAN (15-712): 0: 906: 58.17		ICAL_HUMAN (1-708): 1.39e-102: 331: 100.00
+	Rn
		646586 CAN2_RAT (13-710): 0: 903: 61.89		ICAL_RAT (4-708): 1.91e-77: 264: 61.02
+	Hs
		595836 CAN3_HUMAN (10-714): 0: 853: 46.18		TITIN_HUMAN (25-582): 4.76e-11: 69: 11.15
+	Hs
		595882 CPNS2_HUMAN (517-714): 2.04e-59: 202: 44.12		ICAL_HUMAN (1-708): 1.39e-102: 331: 100.00