HitPredict

Interactor 1: ADRB2 (P07550)
Beta-2 adrenergic receptor (Beta-2 adrenoreceptor) (Beta-2 adrenoceptor)
Gene: ADRB2

Interactor 2: GNAI1 (P63096)
Guanine nucleotide-binding protein G(i) subunit alpha-1 (Adenylate cyclase-inhibiting G alpha protein)
Gene: GNAI1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	22759790
Identification Methods	fluorescent resonance energy transfer
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	7tm_1~G-alpha
Common GO terms	GO:0005886 - plasma membrane GO:0007188 - adenylate cyclase-modulating G protein-coupled receptor signaling pathway
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 413 Hs			1 354
+	Hs
		428884 ADRB2_HUMAN (1-413): 1.07e-122: 363: 100.00		GNAI3_HUMAN (1-354): 1.51e-179: 503: 93.79
+	Hs
		391305 ADRB2_HUMAN (1-413): 1.07e-122: 363: 100.00		GNAI2_HUMAN (1-354): 3.51e-178: 499: 87.89
+	Hs
		428911 ADRB2_HUMAN (1-413): 1.07e-122: 363: 100.00		GNAT2_HUMAN (1-354): 8.28e-172: 483: 69.49
+	Hs
		429010 ADRB2_HUMAN (1-413): 1.07e-122: 363: 100.00		GNAS2_HUMAN (1-354): 3.5e-143: 412: 38.23
+	Hs
		450979 OPRM_HUMAN (5-381): 1.32e-67: 221: 20.57		GNAO_HUMAN (1-354): 4.45e-175: 491: 72.11
+	Hs
		580402 DRD5_HUMAN (50-348): 3.24e-80: 256: 34.04		GNAZ_HUMAN (1-353): 2.73e-160: 454: 67.23
+	Hs
		602214 DRD5_HUMAN (50-348): 3.24e-80: 256: 34.04		GNA13_HUMAN (2-353): 1.72e-155: 443: 39.17
+	Hs
		602211 DRD5_HUMAN (50-348): 3.24e-80: 256: 34.04		GNAS2_HUMAN (1-354): 3.5e-143: 412: 38.23
+	Hs
		391310 ADA2A_HUMAN (3-229): 5.19e-38: 144: 36.36		GNAI2_HUMAN (1-354): 3.51e-178: 499: 87.89
+	Hs
		445801 ADA2A_HUMAN (3-229): 5.19e-38: 144: 36.36		GNAO_HUMAN (1-354): 4.45e-175: 491: 72.11