Protein: MRT4
Ribosome assembly factor MRT4 (mRNA turnover protein 4)

Gene: MRT4
Organism: Saccharomyces cerevisiae S288C
Interactions: 199
UniProt ID: P33201

Gene Ontology (top 5):
GO:0000027 - ribosomal large subunit assembly
GO:0000055 - ribosomal large subunit export from nucleus
GO:0000956 - nuclear-transcribed mRNA catabolic process
GO:0005634 - nucleus
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

750139

ARX1
Probable metalloprotease ARX1

10

3

Small-scale

0.750

High

750114

PESC
Pescadillo homolog

10

2

Small-scale

0.748

High

750117

NOG2
Nucleolar GTP-binding protein 2

8

6

Small-scale

0.744

High

750178

IF6
Eukaryotic translation initiation factor 6

7

2

Small-scale

0.743

High

750157

BUD20
Bud site selection protein 20

6

1

Small-scale

0.733

High

750087

NSA2
Ribosome biogenesis protein NSA2

6

2

Small-scale

0.729

High

750096

NOP2
25S rRNA

6

5

Small-scale

0.729

High

750080

RIX1
Pre-rRNA-processing protein RIX1

6

1

Small-scale

0.726

High

750134

NOG1
Nucleolar GTP-binding protein 1

6

7

Small-scale

0.721

High

750075

CIC1
Proteasome-interacting protein CIC1

5

2

Small-scale

0.709

High

673555

NLE1
Ribosome assembly protein 4

5

9

Small-scale

0.702

High

750086

NUG1
Nuclear GTP-binding protein NUG1

5

6

Small-scale

0.702

High

750138

HAS1
ATP-dependent RNA helicase HAS1

5

12

Small-scale

0.702

High

750084

NOC2
Nucleolar complex protein 2

4

2

Small-scale

0.686

High

750063

RPF2
Ribosome biogenesis protein RPF2

4

2

Small-scale

0.683

High

750156

RLP24
Ribosome biogenesis protein RLP24

4

7

Small-scale

0.683

High

750076

SSF1
Ribosome biogenesis protein SSF1

4

2

Small-scale

0.676

High

750111

NSA1
Ribosome biogenesis protein NSA1

4

2

Small-scale

0.676

High

394402

EF1A
Elongation factor 1-alpha

1

3

High-throughput

0.665

High

750120

NOP13
Nucleolar protein 13

3

2

Small-scale

0.656

High

750146

ERB1
Ribosome biogenesis protein ERB1

3

6

Small-scale

0.656

High

750112

LSG1
Large subunit GTPase 1

3

6

Small-scale

0.650

High

513660

RL2A
Large ribosomal subunit protein uL2A

3

2

Small-scale

0.640

High

682223

SPB4
ATP-dependent rRNA helicase SPB4

3

9

High-throughput

0.640

High

684669

RL5
Large ribosomal subunit protein uL18

3

2

Small-scale

0.640

High

750095

RLP7
Ribosome biogenesis protein RLP7

3

6

Small-scale

0.640

High

750104

ALB1
Ribosome biogenesis protein ALB1

3

1

Small-scale

0.640

High

750121

NOP15
Ribosome biogenesis protein 15

3

2

Small-scale

0.640

High

750175

DBP10
ATP-dependent RNA helicase DBP10

3

6

Small-scale

0.640

High

750088

SSB2
Ribosome-associated molecular chaperone SSB2

3

2

High-throughput

0.634

High

427199

RLA0
Large ribosomal subunit protein uL10

1

3

Small-scale

0.618

High

514257

RL12B
Large ribosomal subunit protein uL11B

1

2

Small-scale

0.618

High

750052

MRT4
Ribosome assembly factor MRT4

1

3

High-throughput

0.618

High

750136

RLI1
Translation initiation factor RLI1

1

3

Small-scale

0.618

High

750159

BRX1
Ribosome biogenesis protein BRX1

2

11

High-throughput

0.611

High

750169

YTM1
Ribosome biogenesis protein YTM1

2

12

High-throughput

0.611

High

750079

NMD3
60S ribosomal export protein NMD3

2

2

Small-scale

0.601

High

750099

LOC1
60S ribosomal subunit assembly/export protein LOC1

2

0

High-throughput

0.585

High

750164

RS10A
Small ribosomal subunit protein eS10A

3

3

Small-scale

0.585

High

433000

RL6B
Large ribosomal subunit protein eL6B

2

4

Small-scale

0.584

High

433174

RL17A
Large ribosomal subunit protein uL22A

2

4

Small-scale

0.584

High

435869

RS13
Small ribosomal subunit protein uS15

2

2

Small-scale

0.584

High

558658

CAF20
Cap-associated protein CAF20

2

1

High-throughput

0.584

High

569953

RL3
Large ribosomal subunit protein uL3

2

3

Small-scale

0.584

High

594282

RPB3
DNA-directed RNA polymerase II subunit RPB3

2

2

Small-scale

0.584

High

633146

MAK11
Protein MAK11

2

10

Small-scale

0.584

High

674515

RS2
Small ribosomal subunit protein uS5

2

2

Small-scale

0.584

High

688988

RL16A
Large ribosomal subunit protein uL13A

2

4

Small-scale

0.584

High

750060

RL14A
Large ribosomal subunit protein eL14A

2

4

Small-scale

0.584

High

750072

ENP1
Essential nuclear protein 1

2

1

High-throughput

0.584

High

750113

CGR1
rRNA-processing protein CGR1

2

1

Small-scale

0.584

High

750115

SDA1
Protein SDA1

2

2

Small-scale

0.584

High

750119

IPI3
Pre-rRNA-processing protein IPI3

2

7

Small-scale

0.584

High

750132

RL6A
Large ribosomal subunit protein eL6A

2

4

Small-scale

0.584

High

750140

RRP17
Ribosomal RNA-processing protein 17

2

1

High-throughput

0.584

High

750155

NOC3
Nucleolar complex-associated protein 3

2

4

Small-scale

0.584

High

750174

MAK21
Ribosome biogenesis protein MAK21

2

7

High-throughput

0.584

High

750078

RPF1
Ribosome production factor 1

2

2

High-throughput

0.571

High

750165

RRS1
Regulator of ribosome biosynthesis

2

2

High-throughput

0.571

High

750168

MDN1
Midasin

2

0

Small-scale

0.559

High

432819

RL9A
Large ribosomal subunit protein uL6A

1

3

High-throughput

0.553

High

721803

XPO1
Exportin-1

1

3

High-throughput

0.536

High

750071

IMB2
Importin subunit beta-2

1

2

High-throughput

0.536

High

750110

PRP43
Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43

1

2

High-throughput

0.536

High

750116

BRE5
UBP3-associated protein BRE5

1

3

High-throughput

0.536

High

750129

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

4

High-throughput

0.536

High

750163

HRK1
Serine/threonine-protein kinase HRK1

1

3

High-throughput

0.536

High

409709

RL24A
Large ribosomal subunit protein eL24A

2

7

Small-scale

0.533

High

511164

RL20B
Large ribosomal subunit protein eL20B

2

2

Small-scale

0.533

High

601011

RL8A
Large ribosomal subunit protein eL8A

2

5

Small-scale

0.533

High

712534

RL8B
Large ribosomal subunit protein eL8B

2

5

Small-scale

0.533

High

750176

RRP36
rRNA biogenesis protein RRP36

1

0

Small-scale

0.513

High

149669

RS9A
Small ribosomal subunit protein uS4A

1

3

High-throughput

0.479

High

381044

H2B1
Histone H2B.1

1

1

High-throughput

0.479

High

381991

H4
Histone H4

1

1

High-throughput

0.479

High

383282

RL28
Large ribosomal subunit protein uL15

1

2

Small-scale

0.479

High

410027

RL25
Large ribosomal subunit protein uL23

1

3

High-throughput

0.479

High

419672

H2A2
Histone H2A.2

1

4

High-throughput

0.479

High

432532

RL7A
Large ribosomal subunit protein uL30A

1

6

High-throughput

0.479

High

433544

RL26A
Large ribosomal subunit protein uL24A

1

4

High-throughput

0.479

High

433994

RL33A
Large ribosomal subunit protein eL33A

1

2

High-throughput

0.479

High

434963

RS3
Small ribosomal subunit protein uS3

1

1

High-throughput

0.479

High

436361

RS31
Ubiquitin-ribosomal protein eS31 fusion protein [Cleaved into: Ubiquitin; Small ribosomal subunit protein eS31

1

2

High-throughput

0.479

High

441808

RS14A
Small ribosomal subunit protein uS11A

1

3

High-throughput

0.479

High

512344

RS6A
Small ribosomal subunit protein eS6A

1

2

High-throughput

0.479

High

513475

RL1A
Large ribosomal subunit protein uL1A

1

6

Small-scale

0.479

High

514546

RS18A
Small ribosomal subunit protein uS13A

1

1

High-throughput

0.479

High

531673

RL4A
Large ribosomal subunit protein uL4A

1

5

Small-scale

0.479

High

534093

MAK16
Protein MAK16

1

1

High-throughput

0.479

High

637196

PWP1
Periodic tryptophan protein 1

1

10

High-throughput

0.479

High

647068

RPC2
DNA-directed RNA polymerase III subunit RPC2

1

3

High-throughput

0.479

High

670521

SIS1
Protein SIS1

1

2

High-throughput

0.479

High

677181

SPB1
27S pre-rRNA

1

2

High-throughput

0.479

High

677331

KRR1
KRR1 small subunit processome component

1

2

High-throughput

0.479

High

689190

RL16B
Large ribosomal subunit protein uL13B

1

4

Small-scale

0.479

High

689352

RS7A
Small ribosomal subunit protein eS7A

1

1

High-throughput

0.479

High

694512

SPT5
Transcription elongation factor SPT5

1

1

High-throughput

0.479

High

706634

TF2B
Transcription initiation factor IIB

1

2

High-throughput

0.479

High

708703

TF3B
Transcription factor IIIB 70 kDa subunit

1

2

High-throughput

0.479

High

709658

BMH1
Protein BMH1

1

2

High-throughput

0.479

High

734909

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

1

High-throughput

0.479

High

745070

AFG2
ATPase family gene 2 protein

1

5

High-throughput

0.479

High

746602

DRS1
ATP-dependent RNA helicase DRS1

1

8

High-throughput

0.479

High

750054

URB1
Nucleolar pre-ribosomal-associated protein 1

1

2

Small-scale

0.479

High

750055

RRP1
Ribosomal RNA-processing protein 1

1

2

High-throughput

0.479

High

750056

RS27A
Small ribosomal subunit protein eS27A

1

1

High-throughput

0.479

High

750058

EBP2
rRNA-processing protein EBP2

1

1

High-throughput

0.479

High

750061

DBP7
ATP-dependent RNA helicase DBP7

1

10

High-throughput

0.479

High

750065

NOP4
Nucleolar protein 4

1

2

High-throughput

0.479

High

750066

GBLP
Small ribosomal subunit protein RACK1

1

10

High-throughput

0.479

High

750067

MAK5
ATP-dependent RNA helicase MAK5

1

9

High-throughput

0.479

High

750069

ATG8
Autophagy-related protein 8

1

6

High-throughput

0.479

High

750073

RS20
Small ribosomal subunit protein uS10

1

1

High-throughput

0.479

High

750074

RL14B
Large ribosomal subunit protein eL14B

1

4

Small-scale

0.479

High

750077

IPI1
Pre-rRNA-processing protein IPI1

1

1

High-throughput

0.479

High

750081

FKBP3
Peptidyl-prolyl cis-trans isomerase

1

2

High-throughput

0.479

High

750083

ECM1
Shuttling pre-60S factor ECM1

1

1

Small-scale

0.479

High

750089

ATAD2
ATPase histone chaperone YTA7

1

6

High-throughput

0.479

High

750093

ULP2
Ubiquitin-like-specific protease 2

1

2

High-throughput

0.479

High

750094

DSN1
Kinetochore-associated protein DSN1

1

1

High-throughput

0.479

High

750097

RL10
Large ribosomal subunit protein uL16

1

3

Small-scale

0.479

High

750098

UTP10
U3 small nucleolar RNA-associated protein 10

1

1

High-throughput

0.479

High

750103

RL17B
Large ribosomal subunit protein uL22B

1

4

High-throughput

0.479

High

750105

MTR4
ATP-dependent RNA helicase DOB1

1

5

Small-scale

0.479

High

750107

RS12
Small ribosomal subunit protein eS12

1

1

High-throughput

0.479

High

750108

RL37A
Large ribosomal subunit protein eL37A

1

2

High-throughput

0.479

High

750109

RL4B
Large ribosomal subunit protein uL4B

1

5

Small-scale

0.479

High

750118

GIS2
Zinc finger protein GIS2

1

6

High-throughput

0.479

High

750122

APJ1
J domain-containing protein APJ1

1

2

High-throughput

0.479

High

750124

RCM1
25S rRNA

1

5

High-throughput

0.479

High

750125

RL15B
Large ribosomal subunit protein eL15B

1

3

Small-scale

0.479

High

750127

RL34A
Large ribosomal subunit protein eL34A

1

4

High-throughput

0.479

High

750130

NOP3
Serine/arginine

1

5

Small-scale

0.479

High

750131

RS15
Small ribosomal subunit protein uS19

1

2

High-throughput

0.479

High

750133

XRN2
5'-3' exoribonuclease 2

1

1

High-throughput

0.479

High

750137

TOM1
E3 ubiquitin-protein ligase TOM1

1

3

High-throughput

0.479

High

750141

DHR1
Probable ATP-dependent RNA helicase DHR1

1

5

High-throughput

0.479

High

750142

RRB1
Ribosome assembly protein RRB1

1

5

High-throughput

0.479

High

750143

VMS1
tRNA endonuclease VMS1

1

1

High-throughput

0.479

High

750144

PUF6
Pumilio homology domain family member 6

1

3

High-throughput

0.479

High

750145

UTP14
U3 small nucleolar RNA-associated protein 14

1

2

High-throughput

0.479

High

750147

RRP5
rRNA biogenesis protein RRP5

1

4

High-throughput

0.479

High

750149

FKBP4
FK506-binding protein 4

1

2

High-throughput

0.479

High

750150

JIP5
WD repeat-containing protein JIP5

1

6

High-throughput

0.479

High

750151

DBP9
ATP-dependent RNA helicase DBP9

1

6

High-throughput

0.479

High

750153

NOC4
Nucleolar complex protein 4

1

7

High-throughput

0.479

High

750154

VAM6
Vacuolar morphogenesis protein 6

1

1

High-throughput

0.479

High

750158

NOP12
Nucleolar protein 12

1

4

High-throughput

0.479

High

750160

REXO4
RNA exonuclease 4

1

2

High-throughput

0.479

High

750161

SGO1
Shugoshin

1

1

High-throughput

0.479

High

750166

NIP7
60S ribosome subunit biogenesis protein NIP7

1

2

High-throughput

0.479

High

750167

BMS1
Ribosome biogenesis protein BMS1

1

3

High-throughput

0.479

High

750170

NOP53
Ribosome biogenesis protein NOP53

1

1

High-throughput

0.479

High

750172

SCC1
Sister chromatid cohesion protein 1

1

1

High-throughput

0.479

High

750173

YRA1
RNA annealing protein YRA1

1

2

High-throughput

0.479

High

750177

NOP58
Nucleolar protein 58

1

2

High-throughput

0.479

High

750179

MEX67
mRNA export factor MEX67

1

2

Small-scale

0.479

High

673154

RRP7
Ribosomal RNA-processing protein 7

1

0

Small-scale

0.458

High

750059

RRP14
Ribosomal RNA-processing protein 14

1

0

High-throughput

0.458

High

750070

YBC8
UPF0642 protein YBL028C

1

0

High-throughput

0.458

High

750085

NOP16
Nucleolar protein 16

1

0

High-throughput

0.458

High

750090

BMT5
25S rRNA

1

0

High-throughput

0.458

High

750106

DENR
Translation machinery-associated protein 22

1

0

Small-scale

0.458

High

750135

ESP1
Separin

1

0

High-throughput

0.458

High

750148

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

0

High-throughput

0.458

High

750152

RRP15
Ribosomal RNA-processing protein 15

1

0

High-throughput

0.458

High

750162

TMA16
Translation machinery-associated protein 16

1

0

High-throughput

0.458

High

750171

YL11B
Transposon Ty1-LR1 Gag-Pol polyprotein

1

0

High-throughput

0.458

High

523477

HSP71
Heat shock protein SSA1

1

2

High-throughput

0.445

High

526278

HSP72
Heat shock protein SSA2

1

2

High-throughput

0.445

High

544304

SSB1
Ribosome-associated molecular chaperone SSB1

1

2

High-throughput

0.445

High

741259

HSP7F
Heat shock protein homolog SSE1

1

5

High-throughput

0.445

High

750062

SET3
SET domain-containing protein 3

1

3

High-throughput

0.445

High

750128

SEN1
Helicase SEN1

1

1

Small-scale

0.445

High

383604

RS17A
Small ribosomal subunit protein eS17A

1

1

High-throughput

0.437

High

434346

RL15A
Large ribosomal subunit protein eL15A

1

3

Small-scale

0.437

High

434539

RL22A
Large ribosomal subunit protein eL22A

1

3

Small-scale

0.437

High

454964

RS19A
Small ribosomal subunit protein eS19A

1

1

High-throughput

0.437

High

502943

RS22A
Small ribosomal subunit protein uS8A

1

1

High-throughput

0.437

High

503769

RL27A
Large ribosomal subunit protein eL27A

1

1

Small-scale

0.437

High

504126

RL31A
Large ribosomal subunit protein eL31A

1

2

High-throughput

0.437

High

512911

RS8A
Small ribosomal subunit protein eS8A

1

2

High-throughput

0.437

High

513973

RL18B
Large ribosomal subunit protein eL18B

1

2

Small-scale

0.437

High

663661

RL24B
Large ribosomal subunit protein eL24B

1

7

Small-scale

0.437

High

747257

RSSA1
Small ribosomal subunit protein uS2A

1

1

High-throughput

0.437

High

750053

RS3A1
Small ribosomal subunit protein eS1A

1

2

High-throughput

0.437

High

750057

EAP1
Protein EAP1

1

1

High-throughput

0.437

High

750064

LONM
Lon protease homolog, mitochondrial

1

5

High-throughput

0.437

High

750082

LAA1
AP-1 accessory protein LAA1

1

1

High-throughput

0.437

High

750092

RL34B
Large ribosomal subunit protein eL34B

1

4

High-throughput

0.437

High

750100

RS10B
Small ribosomal subunit protein eS10B

1

3

Small-scale

0.437

High

750123

SAM50
Sorting assembly machinery 50 kDa subunit

1

1

High-throughput

0.437

High

750126

RL22B
Large ribosomal subunit protein eL22B

1

3

Small-scale

0.437

High

750102

PFD1
Prefoldin subunit 1

1

0

High-throughput

0.426

High

750091

MAM33
Mitochondrial acidic protein MAM33

1

0

High-throughput

0.269

Low

750101

SPC1
Signal peptidase complex subunit 1

1

0

High-throughput

0.269

Low

750068

NU170
Nucleoporin NUP170

1

0

High-throughput

0.249

Low

743934

YEF1
ATP-NADH kinase YEF1

1

0

High-throughput

0.238

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025