HitPredict

Interactor 1: SEC4 (P07560)
Ras-related protein SEC4 (Suppressor of RHO3 protein 6)
Gene: SEC4

Interactor 2: GYP1 (Q08484)
GTPase-activating protein GYP1 (GAP for YPT1)
Gene: GYP1

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.60	1.00	0.778

Property	Details
Experiments	16855591, 9452439
Identification Methods	gtpase assay, enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	RabGAP-TBC~Ras
Common GO terms	GO:0005739 - mitochondrion
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 215 Sc			1 637
+	Sc
		350927 YPT1_YEAST (13-215): 2.85e-85: 252: 46.60		GYP1_YEAST (1-637): 1.25e-172: 507: 100.00
+	Hs
		918951 RAB1A_HUMAN (10-215): 3.47e-83: 247: 49.28		TBC17_HUMAN (3-577): 1.03e-87: 288: 15.64
+	Hs
		914391 RB11A_HUMAN (10-215): 5.54e-82: 244: 39.44		TB22B_HUMAN (101-546): 2.21e-88: 285: 30.85
+	Sc
		429233 SEC4_YEAST (1-215): 6.97e-82: 244: 100.00		GYP2_YEAST (39-629): 2.1e-83: 283: 12.90
+	Os
		1130875 Q84TA8_ORYSJ (16-215): 9.63e-80: 239: 53.47		Q5SMT0_ORYSJ (65-563): 1.13e-86: 286: 16.37
+	Os
		772871 RIC2_ORYSJ (7-215): 9.22e-80: 239: 40.00		Q5SMT0_ORYSJ (65-563): 1.13e-86: 286: 16.37
+	Os
		1130874 Q7XHP7_ORYSJ (16-215): 3.31e-79: 237: 53.20		Q5SMT0_ORYSJ (65-563): 1.13e-86: 286: 16.37
+	Hs
		894809 RAB8A_HUMAN (13-211): 1.32e-78: 235: 52.00		TBC17_HUMAN (3-577): 1.03e-87: 288: 15.64
+	Hs
		914423 RB11A_HUMAN (10-215): 5.54e-82: 244: 39.44		TBC14_HUMAN (16-565): 1.54e-81: 273: 13.63
+	Hs
		233036 RB11A_HUMAN (10-215): 5.54e-82: 244: 39.44		TBC12_HUMAN (41-565): 1.33e-80: 272: 14.92
+	Hs
		894747 RAB8A_HUMAN (13-211): 1.32e-78: 235: 52.00		TBC9B_HUMAN (142-630): 3.63e-81: 280: 14.06
+	Dm
		185710 O18335_DROME (10-215): 3.03e-79: 237: 37.09		Q9VPL5_DROME (33-585): 1.47e-82: 276: 17.49
+	Hs
		894778 RAB8A_HUMAN (13-211): 1.32e-78: 235: 52.00		TBC15_HUMAN (128-574): 2.24e-82: 275: 18.03
+	Hs
		1079972 RB11B_HUMAN (10-215): 8.47e-79: 236: 38.14		TBC14_HUMAN (16-565): 1.54e-81: 273: 13.63
+	Hs
		321281 RB11A_HUMAN (10-215): 5.54e-82: 244: 39.44		TBCD8_HUMAN (110-637): 1.37e-73: 258: 11.97
+	Hs
		914176 RB11A_HUMAN (10-215): 5.54e-82: 244: 39.44		TBCD1_HUMAN (56-627): 1.06e-72: 256: 15.20
+	Hs
		894727 RAB8A_HUMAN (13-211): 1.32e-78: 235: 52.00		TBC8B_HUMAN (133-631): 4.91e-74: 259: 14.82
+	Hs
		914259 RB11A_HUMAN (10-215): 5.54e-82: 244: 39.44		TBCD5_HUMAN (198-619): 1.03e-70: 246: 13.53
+	Sc
		429244 SEC4_YEAST (1-215): 6.97e-82: 244: 100.00		GYL1_YEAST (4-608): 3.67e-67: 235: 12.26