HitPredict

Interactor 1: PROF1 (P07737)
Profilin-1 (Epididymis tissue protein Li 184a) (Profilin I)
Gene: PFN1

Interactor 2: ENAH (Q8N8S7)
Protein enabled homolog
Gene: ENAH

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	0.60	0.595

Property	Details
Experiments	34079125, 9473484
Identification Methods	proximity labelling technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003779 - actin binding GO:0005829 - cytosol GO:0005856 - cytoskeleton GO:0005925 - focal adhesion
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 140 Hs			1 591
+	Hs
		714977 PROF2_HUMAN (1-140): 1.13e-74: 220: 61.43		ENAH_HUMAN (1-591): 2.13e-77: 258: 100.00
+	Hs
		430194 PROF1_HUMAN (1-140): 1.1e-77: 227: 100.00		ITSN1_HUMAN (124-263): 2.96e-29: 125: 37.59
+	Hs
		430372 PROF1_HUMAN (1-140): 1.1e-77: 227: 100.00		EVL_HUMAN (1-374): 7.41e-27: 115: 32.71
+	Mm
		936836 PROF2_MOUSE (1-140): 9.83e-75: 220: 61.43		VASP_MOUSE (380-590): 1.28e-29: 122: 33.18
+	Hs
		430285 PROF1_HUMAN (1-140): 1.1e-77: 227: 100.00		TITIN_HUMAN (81-495): 1.61e-25: 114: 11.06
+	Hs
		715013 PROF2_HUMAN (1-140): 1.13e-74: 220: 61.43		EVL_HUMAN (1-374): 7.41e-27: 115: 32.71
+	Hs
		430098 PROF1_HUMAN (1-140): 1.1e-77: 227: 100.00		VASP_HUMAN (263-590): 7.68e-20: 93.6: 29.18
+	Mm
		923919 PROF1_MOUSE (1-140): 5.37e-77: 226: 95.71		ENAH_MOUSE (242-591): 1.85e-17: 88.4: 74.57
+	Hs
		714941 PROF2_HUMAN (1-140): 1.13e-74: 220: 61.43		VASP_HUMAN (263-590): 7.68e-20: 93.6: 29.18
+	Mm
		975407 PROF2_MOUSE (1-140): 9.83e-75: 220: 61.43		ENAH_MOUSE (242-591): 1.85e-17: 88.4: 74.57