HitPredict

Interactor 1: PROF1 (P07737)
Profilin-1 (Epididymis tissue protein Li 184a) (Profilin I)
Gene: PFN1

Interactor 2: WASF2 (Q9Y6W5)
Actin-binding protein WASF2 (Protein WAVE-2) (Verprolin homology domain-containing protein 2) (Wiskott-Aldrich syndrome protein family member 2) (WASP family protein member 2)
Gene: WASF2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	34079125, 35271311
Identification Methods	proximity labelling technology, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003779 - actin binding GO:0005829 - cytosol GO:0030036 - actin cytoskeleton organization GO:0045296 - cadherin binding GO:0051497 - negative regulation of stress fiber assembly and 1 others more... GO:0070062 - extracellular exosome
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 140 Hs			1 498
+	Hs
		430287 PROF1_HUMAN (1-140): 1.1e-77: 227: 100.00		WASF1_HUMAN (1-496): 3.22e-43: 162: 43.19
+	Hs
		203199 PROF1_HUMAN (1-140): 1.1e-77: 227: 100.00		SYNJ1_HUMAN (36-496): 2.09e-41: 161: 13.30
+	Hs
		714986 PROF2_HUMAN (1-140): 1.13e-74: 220: 61.43		WASF1_HUMAN (1-496): 3.22e-43: 162: 43.19
+	Mm
		1247002 PROF2_MOUSE (1-140): 9.83e-75: 220: 61.43		WASF1_MOUSE (1-496): 3.12e-42: 160: 43.19
+	Hs
		430285 PROF1_HUMAN (1-140): 1.1e-77: 227: 100.00		TITIN_HUMAN (198-454): 8.71e-21: 98.9: 17.05
+	Mm
		923936 PROF1_MOUSE (1-140): 5.37e-77: 226: 95.71		PCLO_MOUSE (102-490): 4.34e-10: 64.7: 10.89
+	Mm
		1337493 PROF2_MOUSE (1-140): 9.83e-75: 220: 61.43		PCLO_MOUSE (102-490): 4.34e-10: 64.7: 10.89