Protein: CREM
cAMP-responsive element modulator (Inducible cAMP early repressor) (ICER)

Gene: CREM
Organism: Homo sapiens
Interactions: 81
UniProt ID: Q03060

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0000977 - RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

593086

CREB1
Cyclic AMP-responsive element-binding protein 1

2

13

Small-scale

0.789

High

1040638

CBP
CREB-binding protein

1

6

Small-scale

0.647

High

952405

IL2
Interleukin-2

3

1

Small-scale

0.640

High

1040632

FHL5
Four and a half LIM domains protein 5

2

9

Small-scale

0.633

High

370637

FOS
Protein c-Fos

1

17

Small-scale

0.618

High

1040623

CREM
cAMP-responsive element modulator

1

17

Small-scale

0.618

High

1040636

CR3L4
Cyclic AMP-responsive element-binding protein 3-like protein 4

1

18

Small-scale

0.618

High

330124

VENTX
Homeobox protein VENTX

2

3

High-throughput

0.606

High

576220

PO2F1
POU domain, class 2, transcription factor 1

2

4

High-throughput

0.606

High

789632

HPCL1
Hippocalcin-like protein 1

2

7

High-throughput

0.606

High

968630

NCS1
Neuronal calcium sensor 1

2

7

High-throughput

0.606

High

1014851

HPCA
Neuron-specific calcium-binding protein hippocalcin

2

5

High-throughput

0.606

High

1034215

ROR2
Tyrosine-protein kinase transmembrane receptor ROR2

2

1

High-throughput

0.606

High

1040631

UBAP2
Ubiquitin-associated protein 2

2

2

High-throughput

0.606

High

1040642

RHXF2
Rhox homeobox family member 2

2

5

High-throughput

0.606

High

1040643

MKNK1
MAP kinase-interacting serine/threonine-protein kinase 1

2

10

High-throughput

0.606

High

1040646

GLIS2
Zinc finger protein GLIS2

2

7

High-throughput

0.606

High

154967

BHE40
Class E basic helix-loop-helix protein 40

2

0

High-throughput

0.580

High

480102

RU1C
U1 small nuclear ribonucleoprotein C

2

0

High-throughput

0.580

High

574226

RSMB
Small nuclear ribonucleoprotein-associated proteins B and B'

2

0

High-throughput

0.580

High

1040644

RUSC1
AP-4 complex accessory subunit RUSC1

2

0

High-throughput

0.580

High

1040626

HDAC1
Histone deacetylase 1

1

7

Small-scale

0.578

High

962891

NCALD
Neurocalcin-delta

2

5

High-throughput

0.553

High

1040640

MIA2
Melanoma inhibitory activity protein 2

2

5

High-throughput

0.552

High

659214

SP100
Nuclear autoantigen Sp-100

1

8

High-throughput

0.541

High

927241

ATX1
Ataxin-1

1

2

High-throughput

0.541

High

1040625

SUH
Recombining binding protein suppressor of hairless

1

1

High-throughput

0.536

High

1040654

DNM3A
DNA

1

4

Small-scale

0.515

High

856649

BAG6
Large proline-rich protein BAG6

1

7

High-throughput

0.515

High

1040641

TSNAX
Translin-associated protein X

1

0

High-throughput

0.513

High

1040647

RAD18
E3 ubiquitin-protein ligase RAD18

1

0

High-throughput

0.513

High

130736

TAF4
Transcription initiation factor TFIID subunit 4

1

2

Small-scale

0.501

High

609923

SPI1
Transcription factor PU.1

1

8

Small-scale

0.501

High

691711

MK03
Mitogen-activated protein kinase 3

1

2

Small-scale

0.501

High

1040651

DNM3L
DNA

1

4

Small-scale

0.501

High

1040653

CSEN
Calsenilin

1

9

Small-scale

0.501

High

932727

EMP3
Epithelial membrane protein 3

1

3

High-throughput

0.494

High

883223

UB2R1
Ubiquitin-conjugating enzyme E2 R1

1

0

Small-scale

0.486

High

993509

UBC9
SUMO-conjugating enzyme UBC9

1

1

High-throughput

0.481

High

1040655

PIAS3
E3 SUMO-protein ligase PIAS3

1

3

High-throughput

0.481

High

628758

TBP
TATA-box-binding protein

1

0

Small-scale

0.480

High

334750

IPO7
Importin-7

1

2

Small-scale

0.479

High

378064

TNFA
Tumor necrosis factor

1

3

Small-scale

0.479

High

378427

IFNG
Interferon gamma

1

2

Small-scale

0.479

High

423764

APOD
Apolipoprotein D

1

3

Small-scale

0.479

High

485787

CATH
Pro-cathepsin H [Cleaved into: Cathepsin H mini chain; Cathepsin H

1

1

Small-scale

0.479

High

633661

PSB1
Proteasome subunit beta type-1

1

1

Small-scale

0.479

High

801275

HSPA9
Stress-70 protein, mitochondrial

1

5

Small-scale

0.479

High

834430

SYIC
Isoleucine--tRNA ligase, cytoplasmic

1

1

Small-scale

0.479

High

907390

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

1

3

Small-scale

0.479

High

945699

FOXL2
Forkhead box protein L2

1

7

Small-scale

0.479

High

979529

H4
Histone H4

1

3

High-throughput

0.479

High

1008097

PRKDC
DNA-dependent protein kinase catalytic subunit

1

3

Small-scale

0.479

High

1040624

MECOM
Histone-lysine N-methyltransferase MECOM

1

4

High-throughput

0.479

High

1040628

IMB1
Importin subunit beta-1

1

2

Small-scale

0.479

High

1040633

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

2

Small-scale

0.479

High

1040634

SMC5
Structural maintenance of chromosomes protein 5

1

4

High-throughput

0.479

High

1040637

GCN1
Stalled ribosome sensor GCN1

1

2

Small-scale

0.479

High

1040639

TNPO1
Transportin-1

1

2

Small-scale

0.479

High

1040645

NAA15
N-alpha-acetyltransferase 15, NatA auxiliary subunit

1

1

Small-scale

0.479

High

1040648

ZRAN1
Ubiquitin thioesterase ZRANB1

1

2

High-throughput

0.479

High

1040649

UBQL2
Ubiquilin-2

1

1

High-throughput

0.479

High

1040650

DDX41
Probable ATP-dependent RNA helicase DDX41

1

3

Small-scale

0.479

High

1040652

C8AP2
CASP8-associated protein 2

1

0

High-throughput

0.460

High

257828

DKC1
H/ACA ribonucleoprotein complex subunit DKC1

1

0

Small-scale

0.458

High

424320

IL4
Interleukin-4

1

0

Small-scale

0.458

High

639373

5NTD
5'-nucleotidase

1

0

Small-scale

0.458

High

681345

PSA3
Proteasome subunit alpha type-3

1

0

Small-scale

0.458

High

701136

PSB5
Proteasome subunit beta type-5

1

0

Small-scale

0.458

High

713367

SPB3
Serpin B3

1

0

Small-scale

0.458

High

724562

S10A7
Protein S100-A7

1

0

Small-scale

0.458

High

849450

NAMPT
Nicotinamide phosphoribosyltransferase

1

0

Small-scale

0.458

High

1040627

DYHC1
Cytoplasmic dynein 1 heavy chain 1

1

0

Small-scale

0.458

High

1040629

NEDD8
Ubiquitin-like protein NEDD8

1

0

Small-scale

0.458

High

1040630

UBR4
E3 ubiquitin-protein ligase UBR4

1

0

Small-scale

0.458

High

687787

SYVC
Valine--tRNA ligase

1

2

Small-scale

0.437

High

1040635

MYOZ3
Myozenin-3

2

0

High-throughput

0.316

High

650134

FGFR3
Fibroblast growth factor receptor 3

1

0

High-throughput

0.268

Low

403278

CSF2
Granulocyte-macrophage colony-stimulating factor

1

0

Small-scale

0.249

Low

591280

CD44
CD44 antigen

1

0

Small-scale

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025