HitPredict

Interactor 1: SYEP (P07814)
Bifunctional glutamate/proline--tRNA ligase (Bifunctional aminoacyl-tRNA synthetase) (Cell proliferation-inducing gene 32 protein) (Glutamatyl-prolyl-tRNA synthetase) [Includes: Glutamate--tRNA ligase (EC 6.1.1.17) (Glutamyl-tRNA synthetase) (GluRS); Proline--tRNA ligase (EC 6.1.1.15) (Prolyl-tRNA synthetase)]
Gene: EPRS1

Interactor 2: SYEP (P07814)
Bifunctional glutamate/proline--tRNA ligase (Bifunctional aminoacyl-tRNA synthetase) (Cell proliferation-inducing gene 32 protein) (Glutamatyl-prolyl-tRNA synthetase) [Includes: Glutamate--tRNA ligase (EC 6.1.1.17) (Glutamyl-tRNA synthetase) (GluRS); Proline--tRNA ligase (EC 6.1.1.15) (Prolyl-tRNA synthetase)]
Gene: EPRS1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.47 1.00 0.692

The method score is based on:

Property Details
Experiments 23263184
Identification Methods molecular sieving, x-ray crystallography
Interaction Type direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains HGTP_anticodon~HGTP_anticodon, HGTP_anticodon~ProRS-C_1, HGTP_anticodon~tRNA-synt_2b, ProRS-C_1~ProRS-C_1, ProRS-C_1~tRNA-synt_2b, tRNA-synt_1c~tRNA-synt_1c, tRNA-synt_1c~tRNA-synt_1c_C, tRNA-synt_2b~tRNA-synt_2b
Common GO terms GO:0004818 - glutamate-tRNA ligase activity
GO:0004827 - proline-tRNA ligase activity
GO:0005524 - ATP binding
GO:0005737 - cytoplasm
GO:0005829 - cytosol
and 16 others

more...
Homologous interactions 12

Homologous interactions

Color coding for hit scores

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Hs

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Last updated: 15 Jul 2024