HitPredict

Interactor 1: CDC4 (P07834)
Cell division control protein 4 (E3 ubiquitin ligase complex SCF subunit CDC4) (F-box protein CDC4)
Gene: CDC4

Interactor 2: SKP1 (P52286)
Suppressor of kinetochore protein 1 (Centromere DNA-binding protein complex CBF3 subunit D) (E3 ubiquitin ligase complex SCF subunit SKP1)
Gene: SKP1

Species: Saccharomyces cerevisiae S288C

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.98 1.00 0.993

The method score is based on:

Property Details
Experiments 10688190, 14747994, 10213692, 10445024, 9346239, 11805837, 8706131, 9346238, 11283612, 12553912, 12582129, 9499404, 15660125, 16432255, 17960736, 18719252, 19882662, 17574027, 20581845, 23000173 and 8 others

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Identification Methods two hybrid, affinity chromatography technology, coimmunoprecipitation, anti tag coimmunoprecipitation, pull down, x-ray crystallography, biochemical, miniaturized immunoprecipitation, cross-linking study
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains F-box-like~Skp1
Common GO terms GO:0000082 - G1/S transition of mitotic cell cycle
GO:0000086 - G2/M transition of mitotic cell cycle
GO:0005634 - nucleus
GO:0006511 - ubiquitin-dependent protein catabolic process
GO:0016567 - protein ubiquitination
and 2 others

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Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 779
Sc

1 194
+ Mm
+ Hs
+ Ce
+ Ce
+ Sp
+ Sp
+ Hs
+ Mm
+ Sc
+ Xl
+ Hs
+ Mm
+ Mm
+ Hs
+ Sp
+ Dm
+ Dm
+ Dm
+ Dm
+ Dm

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Last updated: 15 Jul 2024