Interactor 1: HS90A (P07900)
Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86) (Heat shock protein family C member 1) (Lipopolysaccharide-associated protein 2) (LAP-2) (LPS-associated protein 2) (Renal carcinoma antigen NY-REN-38)
Gene: HSP90AA1

Interactor 2: HS90A (P07900)
Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86) (Heat shock protein family C member 1) (Lipopolysaccharide-associated protein 2) (LAP-2) (LPS-associated protein 2) (Renal carcinoma antigen NY-REN-38)
Gene: HSP90AA1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.94 1.00 0.970

The method score is based on:

Property Details
Experiments 26151834, 16169070, 21360678, 12853476, 8289821, 21460846, 25036637
Identification Methods pull down, two hybrid, affinity chromatography technology, molecular sieving, blue native page, cross-linking study, anti tag coimmunoprecipitation, two hybrid pooling approach, luminescence based mammalian interactome mapping
Interaction Type direct interaction, physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains HATPase_c_3~HATPase_c_3, HATPase_c_3~HSP90, HSP90~HSP90
Common GO terms GO:0001764 - neuron migration
GO:0001934 - positive regulation of protein phosphorylation
GO:0002134 - UTP binding
GO:0002135 - CTP binding
GO:0002218 - activation of innate immune response
and 89 others

more...

Homologous interactions 18

Homologous interactions

Color coding for hit scores

1 732
Hs

1 732
+ Mm
+ Hs
+ Hs
+ Mm
+ Hs
+ Hs
+ At
+ Hs
+ Ce
+ Sp
+ Ca
+ Hs
+ Sc
+ Sc
+ Hs
+ Hs
+ Hs
+ Dm

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024