HitPredict

Interactor 1: HS90A (P07900)
Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86) (Heat shock protein family C member 1) (Lipopolysaccharide-associated protein 2) (LAP-2) (LPS-associated protein 2) (Renal carcinoma antigen NY-REN-38)
Gene: HSP90AA1

Interactor 2: CDK2 (P24941)
Cyclin-dependent kinase 2 (EC 2.7.11.22) (Cell division protein kinase 2) (p33 protein kinase)
Gene: CDK2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.789

Property	Details
Experiments	21319273, 23455922
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	HSP90~Pkinase
Common GO terms	GO:0005524 - ATP binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 732 Hs			1 298
+	Hs
		437908 HS90B_HUMAN (19-732): 0: 1059: 86.13		CDK2_HUMAN (1-298): 8.79e-167: 466: 100.00
+	Hs
		431741 HS90A_HUMAN (1-732): 0: 1087: 100.00		CDK3_HUMAN (1-294): 1.8e-154: 435: 76.87
+	Hs
		414683 HS90A_HUMAN (1-732): 0: 1087: 100.00		CDK1_HUMAN (1-289): 7.44e-144: 408: 66.90
+	Hs
		438075 HS90B_HUMAN (19-732): 0: 1059: 86.13		CDK3_HUMAN (1-294): 1.8e-154: 435: 76.87
+	Hs
		431743 HS90A_HUMAN (1-732): 0: 1087: 100.00		CDK5_HUMAN (1-292): 1.62e-138: 394: 59.39
+	Hs
		438077 HS90B_HUMAN (19-732): 0: 1059: 86.13		CDK5_HUMAN (1-292): 1.62e-138: 394: 59.39
+	Hs
		431662 HS90A_HUMAN (1-732): 0: 1087: 100.00		CDK7_HUMAN (2-298): 9.81e-124: 359: 44.00
+	Hs
		438004 HS90B_HUMAN (19-732): 0: 1059: 86.13		CDK7_HUMAN (2-298): 9.81e-124: 359: 44.00
+	Hs
		538107 ENPL_HUMAN (14-701): 0: 898: 46.78		CDK2_HUMAN (1-298): 8.79e-167: 466: 100.00
+	Sp
		383458 HSP90_SCHPO (15-732): 0: 914: 62.08		CDK1_SCHPO (1-290): 4.04e-137: 391: 65.32
+	Ca
		793050 HSP90_CANAL (12-732): 0: 914: 60.50		CDK1_CANAL (1-286): 1.39e-136: 390: 65.40
+	Sc
		339312 HSP82_YEAST (16-732): 0: 907: 60.08		CDK1_YEAST (1-288): 3.57e-132: 378: 62.12
+	Sc
		365744 HSP82_YEAST (16-732): 0: 907: 60.08		PHO85_YEAST (3-290): 6.29e-131: 375: 54.88
+	Sc
		339406 HSC82_YEAST (16-732): 0: 902: 59.39		CDK1_YEAST (1-288): 3.57e-132: 378: 62.12
+	Sc
		543138 HSC82_YEAST (16-732): 0: 902: 59.39		PHO85_YEAST (3-290): 6.29e-131: 375: 54.88
+	Hs
		841224 H90B3_HUMAN (19-732): 0: 728: 65.41		CDK7_HUMAN (2-298): 9.81e-124: 359: 44.00
+	Hs
		960099 H90B4_HUMAN (30-604): 0: 571: 62.61		CDK3_HUMAN (1-294): 1.8e-154: 435: 76.87
+	Hs
		841223 H90B4_HUMAN (30-604): 0: 571: 62.61		CDK7_HUMAN (2-298): 9.81e-124: 359: 44.00