Protein: AP2A
Transcription factor AP-2-alpha (AP2-alpha) (AP-2 transcription factor) (Activating enhancer-binding protein 2-alpha) (Activator protein 2) (AP-2)

Gene: AP2A, TFAP2A
Organism: Homo sapiens
Interactions: 163
UniProt ID: P05549

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0000976 - transcription cis-regulatory region binding
GO:0000977 - RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

431583

AP2D
Transcription factor AP-2-delta

2

9

High-throughput

0.789

High

431591

AP2B
Transcription factor AP-2-beta

2

9

Small-scale

0.789

High

431494

SP1
Transcription factor Sp1

3

1

Small-scale

0.665

High

413013

P53
Cellular tumor antigen p53

2

2

Small-scale

0.651

High

431559

EP300
Histone acetyltransferase p300

2

2

Small-scale

0.631

High

431581

KCTD1
BTB/POZ domain-containing protein KCTD1

2

5

Small-scale

0.631

High

431542

UBC9
SUMO-conjugating enzyme UBC9

2

2

Small-scale

0.628

High

431492

NPM
Nucleophosmin

2

0

Small-scale

0.628

High

431606

CITE2
Cbp/p300-interacting transactivator 2

2

4

Small-scale

0.625

High

431593

AP2C
Transcription factor AP-2 gamma

1

9

Small-scale

0.618

High

431552

EWS
RNA-binding protein EWS

2

7

High-throughput

0.611

High

431560

INCA1
Protein INCA1

2

1

High-throughput

0.606

High

431603

KCD15
BTB/POZ domain-containing protein KCTD15

2

5

Small-scale

0.595

High

431544

CSK2B
Casein kinase II subunit beta

1

1

Small-scale

0.586

High

403733

GCR
Glucocorticoid receptor

2

5

Small-scale

0.584

High

431549

H33
Histone H3.3

2

1

Small-scale

0.584

High

431528

EPS15
Epidermal growth factor receptor substrate 15

2

0

Small-scale

0.577

High

124568

EYA2
Protein phosphatase EYA2

2

2

High-throughput

0.576

High

431623

EPN1
Epsin-1

2

0

Small-scale

0.569

High

370924

MYC
Myc proto-oncogene protein

1

4

Small-scale

0.561

High

431504

XRCC6
X-ray repair cross-complementing protein 6

1

4

Small-scale

0.561

High

431505

XRCC5
X-ray repair cross-complementing protein 5

1

4

Small-scale

0.561

High

431541

AP2B1
AP-2 complex subunit beta

2

0

Small-scale

0.559

High

431533

MAX
Protein max

1

4

High-throughput

0.554

High

431532

AAPK2
5'-AMP-activated protein kinase catalytic subunit alpha-2

1

0

Small-scale

0.554

High

431555

TF65
Transcription factor p65

1

3

Small-scale

0.552

High

431561

MKRN3
E3 ubiquitin-protein ligase makorin-3

1

0

High-throughput

0.549

High

431491

RB
Retinoblastoma-associated protein

1

0

Small-scale

0.537

High

431515

APC
Adenomatous polyposis coli protein

1

0

Small-scale

0.537

High

133073

FOXE1
Forkhead box protein E1

1

2

High-throughput

0.536

High

166108

AIM2
Interferon-inducible protein AIM2

1

2

High-throughput

0.536

High

431558

SSRP1
FACT complex subunit SSRP1

1

1

High-throughput

0.536

High

431577

IFIX
Pyrin and HIN domain-containing protein 1

1

2

High-throughput

0.536

High

431605

FOXB1
Forkhead box protein B1

1

2

High-throughput

0.536

High

285034

EED
Polycomb protein EED

1

0

High-throughput

0.513

High

429143

JUN
Transcription factor Jun

1

0

High-throughput

0.513

High

431499

PARP1
Poly [ADP-ribose] polymerase 1

1

0

High-throughput

0.513

High

431571

H2B2E
Histone H2B type 2-E

1

0

High-throughput

0.513

High

431592

MY18A
Unconventional myosin-XVIIIa

1

0

High-throughput

0.513

High

431600

RBM14
RNA-binding protein 14

1

0

High-throughput

0.513

High

431523

PPARG
Peroxisome proliferator-activated receptor gamma

1

7

Small-scale

0.501

High

431568

KPCD1
Serine/threonine-protein kinase D1

1

1

Small-scale

0.501

High

431601

CITE4
Cbp/p300-interacting transactivator 4

1

7

Small-scale

0.501

High

431615

MARK1
Serine/threonine-protein kinase MARK1

1

1

Small-scale

0.501

High

431502

BCL2
Apoptosis regulator Bcl-2

1

0

Small-scale

0.493

High

431616

SH3B4
SH3 domain-binding protein 4

1

0

Small-scale

0.493

High

431621

AP4E1
AP-4 complex subunit epsilon-1

1

1

High-throughput

0.489

High

431512

NFKB1
Nuclear factor NF-kappa-B p105 subunit

1

3

Small-scale

0.481

High

431510

VEGFA
Vascular endothelial growth factor A, long form

1

0

Small-scale

0.480

High

431543

YBOX1
Y-box-binding protein 1

1

0

Small-scale

0.480

High

431545

CSK21
Casein kinase II subunit alpha

1

0

Small-scale

0.480

High

431553

OCRL
Inositol polyphosphate 5-phosphatase OCRL

1

0

Small-scale

0.480

High

431612

SRA1
Steroid receptor RNA activator 1

1

0

Small-scale

0.480

High

169894

AURKA
Aurora kinase A

1

2

Small-scale

0.479

High

259302

BRD4
Bromodomain-containing protein 4

1

1

High-throughput

0.479

High

347463

BAG3
BAG family molecular chaperone regulator 3

1

1

High-throughput

0.479

High

362587

EGFR
Epidermal growth factor receptor

1

2

Small-scale

0.479

High

431501

ANDR
Androgen receptor

1

5

Small-scale

0.479

High

431506

CFTR
Cystic fibrosis transmembrane conductance regulator

1

1

Small-scale

0.479

High

431524

BRCA1
Breast cancer type 1 susceptibility protein

1

1

Small-scale

0.479

High

431529

ATRX
Transcriptional regulator ATRX

1

1

Small-scale

0.479

High

431530

SOX2
Transcription factor SOX-2

1

1

Small-scale

0.479

High

431538

H4
Histone H4

1

2

High-throughput

0.479

High

431546

H31
Histone H3.1

1

1

High-throughput

0.479

High

431569

ERBB4
Receptor tyrosine-protein kinase erbB-4

1

2

Small-scale

0.479

High

431585

DTX2
Probable E3 ubiquitin-protein ligase DTX2

1

1

High-throughput

0.479

High

431586

SMC5
Structural maintenance of chromosomes protein 5

1

1

High-throughput

0.479

High

431604

EPAS1
Endothelial PAS domain-containing protein 1

1

1

Small-scale

0.479

High

431607

WWTR1
WW domain-containing transcription regulator protein 1

1

2

High-throughput

0.479

High

167183

IRF6
Interferon regulatory factor 6

1

0

Small-scale

0.458

High

431493

ADRB2
Beta-2 adrenergic receptor

1

0

Small-scale

0.458

High

431503

CADH1
Cadherin-1

1

0

Small-scale

0.458

High

431517

TYY1
Transcriptional repressor protein YY1

1

0

Small-scale

0.458

High

431520

CTNB1
Catenin beta-1

1

0

Small-scale

0.458

High

431522

DEK
Protein DEK

1

0

Small-scale

0.458

High

431525

COIL
Coilin

1

0

High-throughput

0.458

High

431531

CEBPA
CCAAT/enhancer-binding protein alpha

1

0

High-throughput

0.458

High

431550

DAB2
Disabled homolog 2

1

0

Small-scale

0.458

High

431556

SUH
Recombining binding protein suppressor of hairless

1

0

High-throughput

0.458

High

431567

TNIP1
TNFAIP3-interacting protein 1

1

0

High-throughput

0.458

High

431572

ZN750
Zinc finger protein 750

1

0

Small-scale

0.458

High

431588

NUP35
Nucleoporin NUP35

1

0

High-throughput

0.458

High

431590

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

0

High-throughput

0.458

High

431624

DNM3A
DNA

1

0

Small-scale

0.458

High

183213

LAMA5
Laminin subunit alpha-5

1

1

High-throughput

0.457

High

190004

TOX3
TOX high mobility group box family member 3

1

2

High-throughput

0.457

High

224584

ACTN4
Alpha-actinin-4

1

1

High-throughput

0.457

High

303057

CCN5
CCN family member 5

1

1

High-throughput

0.457

High

384081

CO1A1
Collagen alpha-1(I) chain

1

4

High-throughput

0.457

High

391684

MT2
Metallothionein-2

1

1

High-throughput

0.457

High

431495

CO1A2
Collagen alpha-2(I) chain

1

4

High-throughput

0.457

High

431513

TENX
Tenascin-X

1

6

High-throughput

0.457

High

431514

FBLN1
Fibulin-1

1

10

High-throughput

0.457

High

431527

IFI27
Interferon alpha-inducible protein 27, mitochondrial

1

3

High-throughput

0.457

High

431562

KLF10
Krueppel-like factor 10

1

2

High-throughput

0.457

High

431566

FHL2
Four and a half LIM domains protein 2

1

3

High-throughput

0.457

High

431574

ZN326
DBIRD complex subunit ZNF326

1

1

High-throughput

0.457

High

431578

MCAF1
Activating transcription factor 7-interacting protein 1

1

1

High-throughput

0.457

High

431579

MOB2
MOB kinase activator 2

1

1

High-throughput

0.457

High

431580

MOB3C
MOB kinase activator 3C

1

1

High-throughput

0.457

High

431602

RANB9
Ran-binding protein 9

1

1

High-throughput

0.457

High

431611

UNKL
Putative E3 ubiquitin-protein ligase UNKL

1

1

High-throughput

0.457

High

431614

DMRT3
Doublesex- and mab-3-related transcription factor 3

1

1

High-throughput

0.457

High

297402

PIAS1
E3 SUMO-protein ligase PIAS1

1

0

High-throughput

0.438

High

358577

LDHA
L-lactate dehydrogenase A chain

1

0

High-throughput

0.438

High

402488

ALDOA
Fructose-bisphosphate aldolase A

1

0

High-throughput

0.438

High

431497

RSSA
Small ribosomal subunit protein uS2

1

0

High-throughput

0.438

High

431507

TCTP
Translationally-controlled tumor protein

1

0

High-throughput

0.438

High

431508

GLNA
Glutamine synthetase

1

0

High-throughput

0.438

High

431516

THTM
3-mercaptopyruvate sulfurtransferase

1

0

High-throughput

0.438

High

431534

RL15
Large ribosomal subunit protein eL15

1

0

High-throughput

0.438

High

431535

RHOA
Transforming protein RhoA

1

0

High-throughput

0.438

High

431536

DCAF7
DDB1- and CUL4-associated factor 7

1

0

High-throughput

0.438

High

431537

ACTA
Actin, aortic smooth muscle

1

0

High-throughput

0.438

High

431548

IN35
Interferon-induced 35 kDa protein

1

0

High-throughput

0.438

High

431551

CDK5
Cyclin-dependent kinase 5

1

0

High-throughput

0.438

High

431563

CTBP1
C-terminal-binding protein 1

1

0

High-throughput

0.438

High

431565

TBB2A
Tubulin beta-2A chain

1

0

High-throughput

0.438

High

431573

TIM50
Mitochondrial import inner membrane translocase subunit TIM50

1

0

High-throughput

0.438

High

431589

DBF4B
Protein DBF4 homolog B

1

0

High-throughput

0.438

High

431596

PELI1
E3 ubiquitin-protein ligase pellino homolog 1

1

0

High-throughput

0.438

High

431599

ZN641
Zinc finger protein 641

1

0

High-throughput

0.438

High

431618

RERE
Arginine-glutamic acid dipeptide repeats protein

1

0

High-throughput

0.438

High

431619

ZMYM2
Zinc finger MYM-type protein 2

1

0

High-throughput

0.438

High

431622

PPME1
Protein phosphatase methylesterase 1

1

0

High-throughput

0.438

High

431594

AP2M1
AP-2 complex subunit mu

1

1

Small-scale

0.437

High

431598

MEG10
Multiple epidermal growth factor-like domains protein 10

1

5

Small-scale

0.437

High

431617

HECW2
E3 ubiquitin-protein ligase HECW2

1

1

High-throughput

0.437

High

431625

AP1M2
AP-1 complex subunit mu-2

1

1

Small-scale

0.437

High

431521

BMI1
Polycomb complex protein BMI-1

1

0

High-throughput

0.426

High

431540

GRB2
Growth factor receptor-bound protein 2

1

0

High-throughput

0.426

High

62883

POTEF
POTE ankyrin domain family member F

1

1

High-throughput

0.417

High

388759

C1QC
Complement C1q subcomponent subunit C

1

1

High-throughput

0.417

High

431496

CFAH
Complement factor H

1

3

High-throughput

0.417

High

431526

COFA1
Collagen alpha-1(XV) chain [Cleaved into: Restin

1

6

High-throughput

0.417

High

431557

LOXL1
Lysyl oxidase homolog 1

1

2

High-throughput

0.417

High

431570

TENXA
Putative tenascin-XA

1

4

High-throughput

0.417

High

431582

CCD80
Coiled-coil domain-containing protein 80

1

1

High-throughput

0.417

High

431608

I27L2
Interferon alpha-inducible protein 27-like protein 2

1

3

High-throughput

0.417

High

431620

DPP2
Dipeptidyl peptidase 2

1

1

High-throughput

0.417

High

431626

FCGBP
IgGFc-binding protein

1

3

High-throughput

0.417

High

431610

GSTO2
Glutathione S-transferase omega-2

5

0

High-throughput

0.378

High

431584

ACOT1
Acyl-coenzyme A thioesterase 1

3

0

High-throughput

0.345

High

431519

TMOD1
Tropomodulin-1

1

0

High-throughput

0.279

Low

345259

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

0

High-throughput

0.249

Low

215742

ERI3
ERI1 exoribonuclease 3

1

0

High-throughput

0.238

Low

406950

THY1
Thy-1 membrane glycoprotein

1

0

High-throughput

0.238

Low

431498

LEG1
Galectin-1

1

0

High-throughput

0.238

Low

431500

PA24B
Cytosolic phospholipase A2 beta

1

0

High-throughput

0.238

Low

431509

ARSA
Arylsulfatase A

1

0

High-throughput

0.238

Low

431511

CBPE
Carboxypeptidase E

1

0

High-throughput

0.238

Low

431518

ATPA
ATP synthase F(1) complex subunit alpha, mitochondrial

1

0

High-throughput

0.238

Low

431539

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

1

0

High-throughput

0.238

Low

431547

NOMO3
BOS complex subunit NOMO3

1

0

High-throughput

0.238

Low

431554

ACY1
Aminoacylase-1

1

0

High-throughput

0.238

Low

431564

SNTA1
Alpha-1-syntrophin

1

0

High-throughput

0.238

Low

431575

HYI
Putative hydroxypyruvate isomerase

1

0

High-throughput

0.238

Low

431576

MORN1
MORN repeat-containing protein 1

1

0

High-throughput

0.238

Low

431587

A16A1
Aldehyde dehydrogenase family 16 member A1

1

0

High-throughput

0.238

Low

431595

TIM14
Mitochondrial import inner membrane translocase subunit TIM14

1

0

High-throughput

0.238

Low

431597

RCC1L
RCC1-like G exchanging factor-like protein

1

0

High-throughput

0.238

Low

431609

TMPS5
Transmembrane protease serine 5

1

0

High-throughput

0.238

Low

431613

SERHL
Serine hydrolase-like protein

1

0

High-throughput

0.238

Low


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Last updated: 11Aug2025