HitPredict

Interactor 1: HS90A (P07900)
Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86) (Heat shock protein family C member 1) (Lipopolysaccharide-associated protein 2) (LAP-2) (LPS-associated protein 2) (Renal carcinoma antigen NY-REN-38)
Gene: HSP90AA1

Interactor 2: EPHA3 (P29320)
Ephrin type-A receptor 3 (EC 2.7.10.1) (EPH-like kinase 4) (EK4) (hEK4) (HEK) (Human embryo kinase) (Tyrosine-protein kinase TYRO4) (Tyrosine-protein kinase receptor ETK1) (Eph-like tyrosine kinase 1)
Gene: EPHA3

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	31577226
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0005576 - extracellular region GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 732 Hs			1 983
+	Hs
		431692 HS90A_HUMAN (1-732): 0: 1087: 100.00		EPHA4_HUMAN (8-983): 0: 1164: 62.40
+	Hs
		431691 HS90A_HUMAN (1-732): 0: 1087: 100.00		EPHB1_HUMAN (28-983): 0: 1162: 55.69
+	Hs
		431561 HS90A_HUMAN (1-732): 0: 1087: 100.00		EPHA2_HUMAN (27-983): 0: 1061: 50.47
+	Hs
		437918 HS90B_HUMAN (19-732): 0: 1059: 86.13		EPHA2_HUMAN (27-983): 0: 1061: 50.47
+	Hs
		431531 HS90A_HUMAN (1-732): 0: 1087: 100.00		EPHA1_HUMAN (7-973): 0: 949: 42.52
+	Hs
		437892 HS90B_HUMAN (19-732): 0: 1059: 86.13		EPHA1_HUMAN (7-973): 0: 949: 42.52
+	Hs
		171280 HS90A_HUMAN (1-732): 0: 1087: 100.00		EPHB6_HUMAN (29-969): 0: 906: 39.84
+	Hs
		171281 HS90B_HUMAN (19-732): 0: 1059: 86.13		EPHB6_HUMAN (29-969): 0: 906: 39.84
+	Hs
		431568 HS90A_HUMAN (1-732): 0: 1087: 100.00		UFO_HUMAN (265-962): 1.06e-153: 479: 22.82
+	Hs
		431788 HS90A_HUMAN (1-732): 0: 1087: 100.00		MERTK_HUMAN (266-925): 7.95e-146: 461: 21.91
+	Hs
		431488 HS90A_HUMAN (1-732): 0: 1087: 100.00		INSRR_HUMAN (295-918): 5.63e-141: 455: 24.85
+	Hs
		431438 HS90A_HUMAN (1-732): 0: 1087: 100.00		IGF1R_HUMAN (366-883): 1.6e-139: 453: 30.02
+	Hs
		431770 HS90A_HUMAN (1-732): 0: 1087: 100.00		TYRO3_HUMAN (289-882): 5.83e-141: 445: 23.41
+	Hs
		437855 HS90B_HUMAN (19-732): 0: 1059: 86.13		INSRR_HUMAN (295-918): 5.63e-141: 455: 24.85
+	Hs
		435497 HS90B_HUMAN (19-732): 0: 1059: 86.13		IGF1R_HUMAN (366-883): 1.6e-139: 453: 30.02
+	Hs
		431445 HS90A_HUMAN (1-732): 0: 1087: 100.00		HCK_HUMAN (599-879): 3.57e-65: 230: 42.40
+	Hs
		411945 HS90A_HUMAN (1-732): 0: 1087: 100.00		FYN_HUMAN (615-879): 1.08e-64: 229: 44.20
+	Rn
		948934 HS90A_RAT (1-732): 0: 1085: 97.95		LYN_RAT (605-879): 1.05e-63: 226: 42.60
+	Hs
		437817 HS90B_HUMAN (19-732): 0: 1059: 86.13		HCK_HUMAN (599-879): 3.57e-65: 230: 42.40
+	Hs
		411949 HS90B_HUMAN (19-732): 0: 1059: 86.13		FYN_HUMAN (615-879): 1.08e-64: 229: 44.20