HitPredict

Interactor 1: HS90A (P07900)
Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86) (Heat shock protein family C member 1) (Lipopolysaccharide-associated protein 2) (LAP-2) (LPS-associated protein 2) (Renal carcinoma antigen NY-REN-38)
Gene: HSP90AA1

Interactor 2: STIP1 (P31948)
Stress-induced-phosphoprotein 1 (STI1) (Hsc70/Hsp90-organizing protein) (Hop) (Renal carcinoma antigen NY-REN-11) (Transformation-sensitive protein IEF SSP 3521)
Gene: STIP1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.98	1.00	0.992

Property	Details
Experiments	24462205, 26496610, 19996313, 26804907, 11413142, 27353360, 35271311, 35760815, 34349018, 37071682, 20159553, 21170051, 20704274, 22315411, 22729780, 19875381, 21360678, 11877417, 10642522, 18285346 and 8 others more... 22504172, 28514442, 10786835, 9452498, 33961781, 33239621, 21235734, 25036637
Identification Methods	affinity chromatography technology, pull down, cross-linking study, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	HSP90~TPR_8
Common GO terms	GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005829 - cytosol GO:0032991 - protein-containing complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 732 Hs			1 543
+	Hs
		111934 K9JA46_HUMAN (1-732): 0: 1087: 100.00		STIP1_HUMAN (1-543): 2.75e-98: 309: 100.00
+	Hs
		437930 HS90B_HUMAN (19-732): 0: 1059: 86.13		STIP1_HUMAN (1-543): 2.75e-98: 309: 100.00
+	Dm
		365481 HSP83_DROME (15-732): 0: 1034: 78.41		Q9VPN5_DROME (1-542): 1.4e-79: 259: 47.42
+	At
		878278 HS902_ARATH (15-732): 0: 982: 68.24		HSOP2_ARATH (3-543): 4.73e-97: 307: 41.86
+	Hs
		432195 HS90A_HUMAN (1-732): 0: 1087: 100.00		DNJC7_HUMAN (209-487): 3.28e-26: 113: 18.28
+	Hs
		432268 HS90A_HUMAN (1-732): 0: 1087: 100.00		RPAP3_HUMAN (2-141): 4.46e-20: 96.1: 27.14
+	Hs
		174556 HS90A_HUMAN (1-732): 0: 1087: 100.00		OGT1_HUMAN (5-261): 5.16e-18: 90: 13.57
+	Hs
		438464 HS90B_HUMAN (19-732): 0: 1059: 86.13		DNJC7_HUMAN (209-487): 3.28e-26: 113: 18.28
+	Hs
		297024 HS90A_HUMAN (1-732): 0: 1087: 100.00		TOM70_HUMAN (207-543): 4.08e-13: 73.8: 11.00
+	Hs
		431774 HS90A_HUMAN (1-732): 0: 1087: 100.00		SPAG1_HUMAN (405-527): 2.93e-11: 68.4: 14.63
+	Hs
		438533 HS90B_HUMAN (19-732): 0: 1059: 86.13		RPAP3_HUMAN (2-141): 4.46e-20: 96.1: 27.14
+	Hs
		174561 HS90B_HUMAN (19-732): 0: 1059: 86.13		OGT1_HUMAN (5-261): 5.16e-18: 90: 13.57
+	Hs
		431797 HS90A_HUMAN (1-732): 0: 1087: 100.00		IFT88_HUMAN (4-150): 8.37e-09: 60.3: 12.93
+	Hs
		213451 HS90A_HUMAN (1-732): 0: 1087: 100.00		SGTA_HUMAN (202-327): 3.98e-09: 60.1: 32.54
+	Hs
		297025 HS90B_HUMAN (19-732): 0: 1059: 86.13		TOM70_HUMAN (207-543): 4.08e-13: 73.8: 11.00
+	Hs
		213454 HS90B_HUMAN (19-732): 0: 1059: 86.13		SGTA_HUMAN (202-327): 3.98e-09: 60.1: 32.54
+	Ce
		183711 HSP90_CAEEL (14-732): 0: 960: 74.83		STIP1_CAEEL (2-280): 5.87e-13: 71.9: 13.24
+	Ca
		804535 HSP90_CANAL (12-732): 0: 914: 60.50		Q5ADP3_CANAL (1-178): 1.05e-12: 73: 8.12
+	Sc
		365568 HSP82_YEAST (16-732): 0: 907: 60.08		TOM70_YEAST (353-515): 2.09e-14: 78: 22.09
+	Sp
		784798 HSP90_SCHPO (15-732): 0: 914: 62.08		STI1_SCHPO (2-278): 8.15e-10: 63.4: 9.86