Protein: WNK1
Serine/threonine-protein kinase WNK1 (EC 2.7.11.1) (Erythrocyte 65 kDa protein) (p65) (Kinase deficient protein) (Protein kinase lysine-deficient 1) (Protein kinase with no lysine 1) (hWNK1)

Gene: WNK1
Organism: Homo sapiens
Interactions: 149
UniProt ID: Q9H4A3

Gene Ontology (top 5):
GO:0002028 - regulation of sodium ion transport
GO:0003084 - positive regulation of systemic arterial blood pressure
GO:0004672 - protein kinase activity
GO:0004674 - protein serine/threonine kinase activity
GO:0005524 - ATP binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

320573

OXSR1
Serine/threonine-protein kinase OSR1

4

19

Small-scale

0.913

High

1317201

WNK3
Serine/threonine-protein kinase WNK3

3

17

High-throughput

0.861

High

1330752

WNK2
Serine/threonine-protein kinase WNK2

2

18

High-throughput

0.817

High

679308

KAP1
cAMP-dependent protein kinase type I-beta regulatory subunit

2

14

High-throughput

0.793

High

1101676

AAK1
AP2-associated protein kinase 1

2

19

High-throughput

0.789

High

117029

SGK1
Serine/threonine-protein kinase Sgk1

2

17

Small-scale

0.754

High

228689

PRKN
E3 ubiquitin-protein ligase parkin

2

16

High-throughput

0.754

High

1294940

WNK4
Serine/threonine-protein kinase WNK4

2

18

Small-scale

0.754

High

1330745

KLHL3
Kelch-like protein 3

6

12

Small-scale

0.730

High

905107

1433G
14-3-3 protein gamma

5

20

High-throughput

0.718

High

683707

1433B
14-3-3 protein beta/alpha

5

20

High-throughput

0.716

High

488802

ARAF
Serine/threonine-protein kinase A-Raf

1

19

High-throughput

0.698

High

545170

PVR
Poliovirus receptor

1

3

High-throughput

0.698

High

972252

MP2K1
Dual specificity mitogen-activated protein kinase kinase 1

1

19

High-throughput

0.698

High

1317818

GLIS2
Zinc finger protein GLIS2

1

7

Small-scale

0.698

High

1330731

WNK1
Serine/threonine-protein kinase WNK1

1

18

High-throughput

0.698

High

504757

HSP7C
Heat shock cognate 71 kDa protein

4

11

High-throughput

0.694

High

894426

CDC42
Cell division control protein 42 homolog

1

15

High-throughput

0.691

High

1022452

TIAM1
Rho guanine nucleotide exchange factor TIAM1

1

17

High-throughput

0.691

High

1292217

AURKB
Aurora kinase B

1

16

High-throughput

0.691

High

1307202

BAG1
BAG family molecular chaperone regulator 1

1

1

High-throughput

0.691

High

1330747

KS6A6
Ribosomal protein S6 kinase alpha-6

1

17

High-throughput

0.691

High

307216

KLHL2
Kelch-like protein 2

4

13

Small-scale

0.683

High

429122

ADRB2
Beta-2 adrenergic receptor

1

0

Small-scale

0.676

High

910021

1433E
14-3-3 protein epsilon

3

20

High-throughput

0.675

High

927519

1433Z
14-3-3 protein zeta/delta

3

20

High-throughput

0.669

High

1044883

AAMP
Angio-associated migratory cell protein

3

7

High-throughput

0.667

High

1330751

T22D4
TSC22 domain family protein 4

3

19

High-throughput

0.667

High

1299635

NED4L
E3 ubiquitin-protein ligase NEDD4-like

3

20

Small-scale

0.661

High

1044703

FHL3
Four and a half LIM domains protein 3

3

6

High-throughput

0.658

High

982491

1433F
14-3-3 protein eta

3

20

High-throughput

0.650

High

1253376

METL6
tRNA N(3)-methylcytidine methyltransferase METTL6

3

0

High-throughput

0.638

High

1267358

RPGF5
Rap guanine nucleotide exchange factor 5

2

6

High-throughput

0.628

High

1312160

AASD1
Alanyl-tRNA editing protein Aarsd1

2

3

High-throughput

0.628

High

498348

KAP0
cAMP-dependent protein kinase type I-alpha regulatory subunit

1

13

High-throughput

0.621

High

161716

GAK
Cyclin-G-associated kinase

1

18

High-throughput

0.618

High

780098

CCNF
Cyclin-F

1

10

High-throughput

0.618

High

981924

RON
Macrophage-stimulating protein receptor

1

20

High-throughput

0.618

High

1036901

SQSTM
Sequestosome-1

1

6

High-throughput

0.618

High

1171700

TRI67
Tripartite motif-containing protein 67

1

20

High-throughput

0.618

High

1330732

PKHA4
Pleckstrin homology domain-containing family A member 4

1

20

High-throughput

0.618

High

1291258

STALP
AMSH-like protease

2

0

High-throughput

0.602

High

1068665

PLEC
Plectin

2

14

High-throughput

0.601

High

681184

ZEP2
Transcription factor HIVEP2

1

6

High-throughput

0.590

High

1330735

TENS1
Tensin-1

1

11

High-throughput

0.590

High

960971

CLH1
Clathrin heavy chain 1

2

6

High-throughput

0.586

High

1080782

ZYX
Zyxin

2

9

High-throughput

0.586

High

451733

CLCB
Clathrin light chain B

2

5

High-throughput

0.584

High

647272

1433T
14-3-3 protein theta

2

20

Small-scale

0.584

High

1330733

RMD5A
E3 ubiquitin-protein transferase RMND5A

2

6

Small-scale

0.584

High

163271

XPO1
Exportin-1

2

15

High-throughput

0.571

High

906129

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

20

Small-scale

0.561

High

262579

TULP3
Tubby-related protein 3

1

1

High-throughput

0.541

High

966770

PFKAP
ATP-dependent 6-phosphofructokinase, platelet type

1

7

High-throughput

0.541

High

1272610

CSN5
COP9 signalosome complex subunit 5

1

7

High-throughput

0.541

High

307276

RCBT2
RCC1 and BTB domain-containing protein 2

1

9

High-throughput

0.536

High

314149

BAG4
BAG family molecular chaperone regulator 4

1

3

High-throughput

0.536

High

324033

BAG2
BAG family molecular chaperone regulator 2

1

5

High-throughput

0.536

High

597545

GSTM3
Glutathione S-transferase Mu 3

1

1

High-throughput

0.536

High

602873

TGM2
Protein-glutamine gamma-glutamyltransferase 2

1

1

High-throughput

0.536

High

639081

S100P
Protein S100-P

1

9

High-throughput

0.536

High

834847

RBP2
E3 SUMO-protein ligase RanBP2

1

6

High-throughput

0.536

High

885611

MLF1
Myeloid leukemia factor 1

1

5

High-throughput

0.536

High

1050785

FHL2
Four and a half LIM domains protein 2

1

6

High-throughput

0.536

High

1203058

LONP2
Lon protease homolog 2, peroxisomal

1

8

High-throughput

0.536

High

1284806

EFMT3
EEF1A lysine methyltransferase 3

1

5

High-throughput

0.536

High

1330744

GTSE1
G2 and S phase-expressed protein 1

1

1

High-throughput

0.536

High

1330746

SPB13
Serpin B13

1

1

High-throughput

0.536

High

684323

1433S
14-3-3 protein sigma

1

20

High-throughput

0.515

High

1218996

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

0

High-throughput

0.513

High

1330738

MOG1
Ran guanine nucleotide release factor

1

0

High-throughput

0.513

High

1330743

HAOX2
2-Hydroxyacid oxidase 2

1

0

High-throughput

0.513

High

868739

ATX1
Ataxin-1

1

2

High-throughput

0.508

High

930392

UBC9
SUMO-conjugating enzyme UBC9

1

10

Small-scale

0.501

High

398948

HMGN2
Non-histone chromosomal protein HMG-17

1

0

High-throughput

0.493

High

1139301

SPAT1
Spermatogenesis-associated protein 1

1

1

High-throughput

0.489

High

1233801

MIA40
Mitochondrial intermembrane space import and assembly protein 40

1

1

High-throughput

0.489

High

135287

E2F3
Transcription factor E2F3

1

1

Small-scale

0.481

High

324618

BAG3
BAG family molecular chaperone regulator 3

1

3

High-throughput

0.481

High

586068

SL9A1
Sodium/hydrogen exchanger 1

1

3

High-throughput

0.481

High

1052939

FLNC
Filamin-C

1

15

High-throughput

0.481

High

1077338

T22D1
TSC22 domain family protein 1

1

20

High-throughput

0.481

High

1242653

TNR6A
Trinucleotide repeat-containing gene 6A protein

1

8

High-throughput

0.481

High

1301786

RANB9
Ran-binding protein 9

1

9

High-throughput

0.481

High

1329789

ZN106
Zinc finger protein 106

1

7

High-throughput

0.481

High

199147

SIAH2
E3 ubiquitin-protein ligase SIAH2

1

6

Small-scale

0.479

High

304341

UBR5
E3 ubiquitin-protein ligase UBR5

1

20

Small-scale

0.479

High

430337

PROF1
Profilin-1

1

4

High-throughput

0.479

High

451559

CLCA
Clathrin light chain A

1

5

High-throughput

0.479

High

518768

IMDH2
Inosine-5'-monophosphate dehydrogenase 2

1

5

High-throughput

0.479

High

553699

RFA2
Replication protein A 32 kDa subunit

1

7

High-throughput

0.479

High

575848

VINC
Vinculin

1

5

High-throughput

0.479

High

652237

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

7

High-throughput

0.479

High

773563

RL13A
Large ribosomal subunit protein uL13

1

1

High-throughput

0.479

High

875315

TERA
Transitional endoplasmic reticulum ATPase

1

6

High-throughput

0.479

High

926008

AP2B1
AP-2 complex subunit beta

1

14

High-throughput

0.479

High

1036476

PICAL
Phosphatidylinositol-binding clathrin assembly protein

1

8

High-throughput

0.479

High

1064716

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

8

High-throughput

0.479

High

1185153

MAEA
E3 ubiquitin-protein transferase MAEA

1

6

Small-scale

0.479

High

1188858

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

9

High-throughput

0.479

High

1200663

NAA40
N-alpha-acetyltransferase 40

1

2

High-throughput

0.479

High

1269607

ESR2
Estrogen receptor beta

1

17

High-throughput

0.479

High

1270441

HDAC2
Histone deacetylase 2

1

10

High-throughput

0.479

High

1289347

SPDLY
Protein Spindly

1

16

High-throughput

0.479

High

1327570

TOLIP
Toll-interacting protein

1

1

High-throughput

0.479

High

1330348

PTN23
Tyrosine-protein phosphatase non-receptor type 23

1

10

Small-scale

0.479

High

269060

CSDE1
Cold shock domain-containing protein E1

1

0

High-throughput

0.460

High

1330734

RENT2
Regulator of nonsense transcripts 2

1

0

High-throughput

0.460

High

116625

ADAS
Alkyldihydroxyacetonephosphate synthase, peroxisomal

1

0

High-throughput

0.458

High

1302980

MMS19
MMS19 nucleotide excision repair protein homolog

1

0

High-throughput

0.458

High

1330739

MED4
Mediator of RNA polymerase II transcription subunit 4

1

0

High-throughput

0.458

High

1330750

CIA2B
Cytosolic iron-sulfur assembly component 2B

1

0

High-throughput

0.458

High

204737

E41L2
Band 4.1-like protein 2

1

9

High-throughput

0.457

High

599732

TNAP3
Tumor necrosis factor alpha-induced protein 3

1

7

High-throughput

0.457

High

657651

ITPI2
Protein ITPRID2

1

3

High-throughput

0.457

High

725018

MYH9
Myosin-9

1

5

High-throughput

0.457

High

1012571

CGNL1
Cingulin-like protein 1

1

6

High-throughput

0.457

High

1024147

LCP2
Lymphocyte cytosolic protein 2

1

6

High-throughput

0.457

High

1024520

CAF1A
Chromatin assembly factor 1 subunit A

1

5

High-throughput

0.457

High

1049647

EIF3A
Eukaryotic translation initiation factor 3 subunit A

1

10

High-throughput

0.457

High

1147381

RPGP2
Rap1 GTPase-activating protein 2

1

5

High-throughput

0.457

High

1206108

RASL3
RAS protein activator like-3

1

16

High-throughput

0.457

High

1232625

SYNPO
Synaptopodin

1

13

High-throughput

0.457

High

1263670

MADD
MAP kinase-activating death domain protein

1

2

High-throughput

0.457

High

1273033

BAD
Bcl2-associated agonist of cell death

1

3

High-throughput

0.457

High

1326739

WWTR1
WW domain-containing transcription regulator protein 1

1

20

High-throughput

0.457

High

1330736

CENPJ
Centromere protein J

1

8

High-throughput

0.457

High

1330742

FA13B
Protein FAM13B

1

17

High-throughput

0.457

High

1330748

HDAC9
Histone deacetylase 9

1

14

High-throughput

0.457

High

1330749

SYNP2
Synaptopodin-2

1

9

High-throughput

0.457

High

1330754

FHOD1
FH1/FH2 domain-containing protein 1

1

3

High-throughput

0.457

High

121019

APBB1
Amyloid beta precursor protein binding family B member 1

1

1

High-throughput

0.445

High

968220

OCRL
Inositol polyphosphate 5-phosphatase OCRL

1

1

High-throughput

0.445

High

1020086

IRAG2
Inositol 1,4,5-triphosphate receptor associated 2

1

0

High-throughput

0.438

High

1242776

SIMC1
SUMO-interacting motif-containing protein 1

1

0

High-throughput

0.438

High

1268559

K0232
Uncharacterized protein KIAA0232

1

0

High-throughput

0.438

High

1303161

RMD3
Regulator of microtubule dynamics protein 3

1

0

High-throughput

0.438

High

1304488

MPP9
M-phase phosphoprotein 9

1

0

High-throughput

0.438

High

1330737

MSL2
E3 ubiquitin-protein ligase MSL2

1

0

High-throughput

0.438

High

1330741

FA53C
Protein FAM53C

1

0

High-throughput

0.438

High

1330753

RIPR2
Rho family-interacting cell polarization regulator 2

1

0

High-throughput

0.438

High

721433

RFA3
Replication protein A 14 kDa subunit

1

7

High-throughput

0.437

High

1159442

FBX42
F-box only protein 42

1

6

High-throughput

0.437

High

1330740

KBTB4
Kelch repeat and BTB domain-containing protein 4

1

15

High-throughput

0.437

High

89986

D6R9G5
Kelch like family member 2

1

17

High-throughput

0.407

High

371287

ATP8
ATP synthase protein 8

1

0

High-throughput

0.251

Low

615561

MAOM
NAD-dependent malic enzyme, mitochondrial

1

0

High-throughput

0.249

Low

66229

ZN839
Zinc finger protein 839

1

0

High-throughput

0.238

Low


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Last updated: 15 Jul 2024