HitPredict

Interactor 1: HS90A (P07900)
Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86) (Heat shock protein family C member 1) (Lipopolysaccharide-associated protein 2) (LAP-2) (LPS-associated protein 2) (Renal carcinoma antigen NY-REN-38)
Gene: HSP90AA1

Interactor 2: M3K8 (P41279)
Mitogen-activated protein kinase kinase kinase 8 (EC 2.7.11.25) (Cancer Osaka thyroid oncogene) (Proto-oncogene c-Cot) (Serine/threonine-protein kinase cot) (Tumor progression locus 2) (TPL-2)
Gene: MAP3K8

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	22939624, 14743216
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association

Property	Details
Interacting Pfam domains	HSP90~Pkinase
Common GO terms	GO:0005524 - ATP binding GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 732 Hs			1 467
+	Hs
		431573 HS90A_HUMAN (1-732): 0: 1087: 100.00		AKT2_HUMAN (31-438): 7.59e-137: 404: 15.46
+	Hs
		431752 HS90A_HUMAN (1-732): 0: 1087: 100.00		KPCE_HUMAN (49-463): 9.48e-132: 399: 16.03
+	Hs
		432376 HS90A_HUMAN (1-732): 0: 1087: 100.00		AKT3_HUMAN (80-460): 5.42e-135: 399: 17.22
+	Hs
		431572 HS90A_HUMAN (1-732): 0: 1087: 100.00		AKT1_HUMAN (49-466): 1.05e-133: 396: 16.17
+	Hs
		431762 HS90A_HUMAN (1-732): 0: 1087: 100.00		KPCT_HUMAN (56-453): 1.4e-130: 395: 16.06
+	Rn
		812703 HS90A_RAT (1-732): 0: 1085: 97.95		AKT1_RAT (43-466): 3.95e-134: 397: 15.64
+	Mm
		432411 HS90A_MOUSE (1-732): 0: 1083: 97.82		AKT1_MOUSE (43-466): 1.83e-134: 398: 16.08
+	Hs
		116956 HS90A_HUMAN (1-732): 0: 1087: 100.00		SGK1_HUMAN (101-466): 2.04e-130: 385: 19.74
+	Mm
		513660 HS90B_MOUSE (19-732): 0: 1063: 86.98		AKT1_MOUSE (43-466): 1.83e-134: 398: 16.08
+	Bt
		964601 HS90B_BOVIN (19-732): 0: 1059: 86.28		AKT1_BOVIN (49-466): 3.62e-134: 397: 16.17
+	Hs
		431945 HS90A_HUMAN (1-732): 0: 1087: 100.00		Q5T853_HUMAN (1-223): 5.66e-125: 364: 100.00
+	Hs
		116958 HS90B_HUMAN (19-732): 0: 1059: 86.13		SGK1_HUMAN (101-466): 2.04e-130: 385: 19.74
+	Hs
		432166 HS90A_HUMAN (1-732): 0: 1087: 100.00		KCC1G_HUMAN (119-462): 1.11e-105: 324: 21.97
+	Hs
		431792 HS90A_HUMAN (1-732): 0: 1087: 100.00		STK4_HUMAN (116-419): 2.68e-103: 318: 25.89
+	Hs
		131544 HS90A_HUMAN (1-732): 0: 1087: 100.00		STK25_HUMAN (142-436): 4.1e-103: 316: 30.80
+	Hs
		131545 HS90B_HUMAN (19-732): 0: 1059: 86.13		STK25_HUMAN (142-436): 4.1e-103: 316: 30.80
+	Hs
		432191 HS90A_HUMAN (1-732): 0: 1087: 100.00		M3K14_HUMAN (107-382): 8.18e-30: 125: 30.66
+	Hs
		432196 HS90A_HUMAN (1-732): 0: 1087: 100.00		M3K5_HUMAN (114-426): 1.3e-27: 118: 29.73
+	Hs
		432286 HS90A_HUMAN (1-732): 0: 1087: 100.00		PAK6_HUMAN (144-388): 1.71e-27: 117: 32.67
+	Hs
		431980 HS90A_HUMAN (1-732): 0: 1087: 100.00		M3K15_HUMAN (146-384): 6.5e-27: 116: 32.27