Protein: AP2C
Transcription factor AP-2 gamma (AP2-gamma) (Activating enhancer-binding protein 2 gamma) (Transcription factor ERF-1)

Gene: AP2C, TFAP2C
Organism: Homo sapiens
Interactions: 94
UniProt ID: Q92754

Gene Ontology (top 5):
GO:0000785 - chromatin
GO:0000977 - RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001227 - DNA-binding transcription repressor activity, RNA polymerase II-specific

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1280269

AP2D
Transcription factor AP-2-delta

1

9

High-throughput

0.691

High

396638

ESR1
Estrogen receptor

4

6

Small-scale

0.666

High

1367939

CITE2
Cbp/p300-interacting transactivator 2

2

4

Small-scale

0.625

High

993683

UBC9
SUMO-conjugating enzyme UBC9

2

2

Small-scale

0.620

High

431593

AP2A
Transcription factor AP-2-alpha

1

9

Small-scale

0.618

High

1145760

ERBB4
Receptor tyrosine-protein kinase erbB-4

1

2

Small-scale

0.561

High

282948

NR1I2
Nuclear receptor subfamily 1 group I member 2

1

8

High-throughput

0.541

High

1367948

WWOX
WW domain-containing oxidoreductase

1

0

Small-scale

0.537

High

166181

AIM2
Interferon-inducible protein AIM2

1

2

High-throughput

0.536

High

167941

IKKB
Inhibitor of nuclear factor kappa-B kinase subunit beta

1

0

High-throughput

0.518

High

909291

CCNG1
Cyclin-G1

1

0

High-throughput

0.518

High

520610

RARA
Retinoic acid receptor alpha

1

5

Small-scale

0.505

High

414326

P53
Cellular tumor antigen p53

1

2

Small-scale

0.501

High

1367936

CITE4
Cbp/p300-interacting transactivator 4

1

7

Small-scale

0.501

High

1367937

GPR22
G-protein coupled receptor 22

1

1

High-throughput

0.494

High

260242

BRD4
Bromodomain-containing protein 4

1

1

High-throughput

0.479

High

372733

MYC
Myc proto-oncogene protein

1

4

Small-scale

0.479

High

799350

BRCA1
Breast cancer type 1 susceptibility protein

1

1

Small-scale

0.479

High

980074

H4
Histone H4

1

2

High-throughput

0.479

High

1067560

EP300
Histone acetyltransferase p300

1

2

High-throughput

0.479

High

1258857

KCTD1
BTB/POZ domain-containing protein KCTD1

1

5

Small-scale

0.479

High

323510

TRI37
E3 ubiquitin-protein ligase TRIM37

1

0

Small-scale

0.458

High

1141839

EEA1
Early endosome antigen 1

1

0

High-throughput

0.458

High

1155612

EZH2
Histone-lysine N-methyltransferase EZH2

1

0

High-throughput

0.458

High

1367951

KDM5B
Lysine-specific demethylase 5B

1

0

Small-scale

0.458

High

124633

EYA2
Protein phosphatase EYA2

1

2

High-throughput

0.457

High

183287

LAMA5
Laminin subunit alpha-5

1

1

High-throughput

0.457

High

224770

ACTN4
Alpha-actinin-4

1

1

High-throughput

0.457

High

303066

CCN5
CCN family member 5

1

1

High-throughput

0.457

High

384289

CO3A1

1

4

High-throughput

0.457

High

391707

MT2
Metallothionein-2

1

1

High-throughput

0.457

High

558301

XRCC6
X-ray repair cross-complementing protein 6

1

4

High-throughput

0.457

High

822127

IFI27
Interferon alpha-inducible protein 27, mitochondrial

1

3

High-throughput

0.457

High

878069

AGRE5
Adhesion G protein-coupled receptor E5

1

1

High-throughput

0.457

High

1010863

TMF1
TATA element modulatory factor

1

2

High-throughput

0.457

High

1123066

FHL2
Four and a half LIM domains protein 2

1

3

High-throughput

0.457

High

1151607

TRIP6
Thyroid receptor-interacting protein 6

1

3

High-throughput

0.457

High

1156169

ZYX
Zyxin

1

3

High-throughput

0.457

High

1367935

RMD5B
E3 ubiquitin-protein transferase RMND5B

1

1

High-throughput

0.457

High

1367943

I27L2
Interferon alpha-inducible protein 27-like protein 2

1

3

High-throughput

0.457

High

1367950

FBLN5
Fibulin-5

1

8

High-throughput

0.457

High

662619

GATA3
Trans-acting T-cell-specific transcription factor GATA-3

1

1

Small-scale

0.445

High

286013

SF3B1
Splicing factor 3B subunit 1

1

0

High-throughput

0.438

High

410487

PRM2
Protamine-2

1

0

High-throughput

0.438

High

578620

FABP4
Fatty acid-binding protein, adipocyte

1

0

High-throughput

0.438

High

665474

EF1B
Elongation factor 1-beta

1

0

High-throughput

0.438

High

688091

EF1G
Elongation factor 1-gamma

1

0

High-throughput

0.438

High

715938

AQP1
Aquaporin-1

1

0

High-throughput

0.438

High

728608

AKT2
RAC-beta serine/threonine-protein kinase

1

0

High-throughput

0.438

High

838246

STAT6
Signal transducer and activator of transcription 6

1

0

High-throughput

0.438

High

920860

ACLY
ATP-citrate synthase

1

0

High-throughput

0.438

High

961619

PHS
Pterin-4-alpha-carbinolamine dehydratase

1

0

High-throughput

0.438

High

992046

RL38
Large ribosomal subunit protein eL38

1

0

High-throughput

0.438

High

996271

EF1A1
Elongation factor 1-alpha 1

1

0

High-throughput

0.438

High

1059235

TISB
mRNA decay activator protein ZFP36L1

1

0

High-throughput

0.438

High

1121713

SAFB2
Scaffold attachment factor B2

1

0

High-throughput

0.438

High

1248051

FIP1
Pre-mRNA 3'-end-processing factor FIP1

1

0

High-throughput

0.438

High

1359567

ATX2L
Ataxin-2-like protein

1

0

High-throughput

0.438

High

1367932

FUBP2
Far upstream element-binding protein 2

1

0

High-throughput

0.438

High

1367934

RM38
Large ribosomal subunit protein mL38

1

0

High-throughput

0.438

High

1367938

TCPH
T-complex protein 1 subunit eta

1

0

High-throughput

0.438

High

1367942

SHRPN
Sharpin

1

0

High-throughput

0.438

High

1367944

JUPI2
Jupiter microtubule associated homolog 2

1

0

High-throughput

0.438

High

1367946

PLS3
Phospholipid scramblase 3

1

0

High-throughput

0.438

High

1367947

MA2C1
Alpha-mannosidase 2C1

1

0

High-throughput

0.438

High

1367949

UXT
Protein UXT

1

0

High-throughput

0.438

High

1367953

SRTD3
SERTA domain-containing protein 3

1

0

High-throughput

0.438

High

1367954

FLVC1
Choline/ethanolamine transporter FLVCR1

1

0

High-throughput

0.438

High

336600

PPN
Papilin

1

3

High-throughput

0.417

High

351576

FBLN4
EGF-containing fibulin-like extracellular matrix protein 2

1

8

High-throughput

0.417

High

384188

CO1A1
Collagen alpha-1(I) chain

1

4

High-throughput

0.417

High

389460

FINC
Fibronectin

1

2

High-throughput

0.417

High

465974

CO1A2
Collagen alpha-2(I) chain

1

4

High-throughput

0.417

High

472336

CFAH
Complement factor H

1

3

High-throughput

0.417

High

551884

CO6A2

1

3

High-throughput

0.417

High

592682

ITB4
Integrin beta-4

1

2

High-throughput

0.417

High

644589

TENX
Tenascin-X

1

6

High-throughput

0.417

High

654543

FBLN1
Fibulin-1

1

10

High-throughput

0.417

High

702194

LYOX
Protein-lysine 6-oxidase

1

2

High-throughput

0.417

High

810587

COFA1
Collagen alpha-1(XV) chain [Cleaved into: Restin

1

6

High-throughput

0.417

High

1022267

FBLN2
Fibulin-2

1

10

High-throughput

0.417

High

1063920

LOXL1
Lysyl oxidase homolog 1

1

2

High-throughput

0.417

High

1086431

FBLN3
EGF-containing fibulin-like extracellular matrix protein 1

1

7

High-throughput

0.417

High

1157436

TENXA
Putative tenascin-XA

1

4

High-throughput

0.417

High

1260664

CCD80
Coiled-coil domain-containing protein 80

1

1

High-throughput

0.417

High

1367945

CD248
Endosialin

1

8

High-throughput

0.417

High

1367952

DPP2
Dipeptidyl peptidase 2

1

1

High-throughput

0.417

High

1367955

FCGBP
IgGFc-binding protein

1

3

High-throughput

0.417

High

1293573

ZFAN4
AN1-type zinc finger protein 4

1

0

High-throughput

0.282

High

181011

LRAD4
Low-density lipoprotein receptor class A domain-containing protein 4

1

0

High-throughput

0.238

Low

1322577

SHSA5
Protein shisa-5

1

0

High-throughput

0.238

Low

1367933

CTHR1
Collagen triple helix repeat-containing protein 1

1

0

High-throughput

0.238

Low

1367940

APOL4
Apolipoprotein L4

1

0

High-throughput

0.238

Low

1367941

WDR83
WD repeat domain-containing protein 83

1

0

High-throughput

0.238

Low


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Last updated: 11Aug2025