HitPredict

Interactor 1: HS90A (P07900)
Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86) (Heat shock protein family C member 1) (Lipopolysaccharide-associated protein 2) (LAP-2) (LPS-associated protein 2) (Renal carcinoma antigen NY-REN-38)
Gene: HSP90AA1

Interactor 2: JAK3 (P52333)
Tyrosine-protein kinase JAK3 (EC 2.7.10.2) (Janus kinase 3) (JAK-3) (Leukocyte janus kinase) (L-JAK)
Gene: JAK3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	32707033
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0019903 - protein phosphatase binding GO:0042981 - regulation of apoptotic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 732 Hs			1 1124
+	Hs
		238331 HS90A_HUMAN (1-732): 0: 1087: 100.00		JAK2_HUMAN (7-1101): 0: 889: 47.80
+	Hs
		431626 HS90A_HUMAN (1-732): 0: 1087: 100.00		ABL2_HUMAN (794-1121): 3.94e-95: 331: 32.22
+	Hs
		337312 HS90A_HUMAN (1-732): 0: 1087: 100.00		ABL1_HUMAN (760-1102): 3.81e-95: 330: 29.48
+	Hs
		431481 HS90A_HUMAN (1-732): 0: 1087: 100.00		SRC_HUMAN (793-1109): 4.7e-100: 328: 29.25
+	Hs
		431433 HS90A_HUMAN (1-732): 0: 1087: 100.00		YES_HUMAN (784-1109): 7.17e-99: 326: 29.36
+	Hs
		411551 HS90A_HUMAN (1-732): 0: 1087: 100.00		LCK_HUMAN (794-1110): 1.37e-97: 321: 30.50
+	Hs
		411945 HS90A_HUMAN (1-732): 0: 1087: 100.00		FYN_HUMAN (790-1109): 4.99e-97: 320: 29.60
+	Hs
		431627 HS90A_HUMAN (1-732): 0: 1087: 100.00		FRK_HUMAN (813-1101): 2.43e-95: 315: 31.96
+	Hs
		431445 HS90A_HUMAN (1-732): 0: 1087: 100.00		HCK_HUMAN (794-1110): 1.01e-94: 314: 28.93
+	Hs
		431451 HS90A_HUMAN (1-732): 0: 1087: 100.00		FGR_HUMAN (783-1110): 2.27e-93: 310: 28.88
+	Hs
		431871 HS90A_HUMAN (1-732): 0: 1087: 100.00		ERBB4_HUMAN (822-1104): 2.36e-87: 310: 36.62
+	Hs
		431434 HS90A_HUMAN (1-732): 0: 1087: 100.00		LYN_HUMAN (781-1110): 2.14e-92: 307: 28.40
+	Hs
		431666 HS90A_HUMAN (1-732): 0: 1087: 100.00		BLK_HUMAN (784-1105): 3.14e-89: 298: 29.63
+	Hs
		431543 HS90A_HUMAN (1-732): 0: 1087: 100.00		JAK1_HUMAN (761-1119): 1.21e-38: 158: 18.62
+	Hs
		431565 HS90A_HUMAN (1-732): 0: 1087: 100.00		TYK2_HUMAN (828-1122): 5.53e-34: 144: 20.62
+	Hs
		337788 HS90A_HUMAN (1-732): 0: 1087: 100.00		EGFR_HUMAN (527-780): 3.22e-18: 92.8: 24.34
+	Hs
		431633 HS90A_HUMAN (1-732): 0: 1087: 100.00		ZAP70_HUMAN (527-773): 4.08e-17: 88.6: 28.02
+	Hs
		431619 HS90A_HUMAN (1-732): 0: 1087: 100.00		CSK_HUMAN (521-787): 4.41e-17: 87.4: 27.01
+	Hs
		431776 HS90A_HUMAN (1-732): 0: 1087: 100.00		ACK1_HUMAN (525-790): 4.96e-16: 85.5: 29.14
+	Hs
		383537 HS90A_HUMAN (1-732): 0: 1087: 100.00		ERBB2_HUMAN (527-780): 1.84e-13: 77.4: 25.00