Protein: AUP1
Lipid droplet-regulating VLDL assembly factor AUP1 (Ancient ubiquitous protein 1)

Gene: AUP1
Organism: Homo sapiens
Interactions: 232
UniProt ID: Q9Y679

Gene Ontology (top 5):
GO:0005776 - autophagosome
GO:0005783 - endoplasmic reticulum
GO:0005789 - endoplasmic reticulum membrane
GO:0005811 - lipid droplet
GO:0009615 - response to virus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

476653

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

4

1

Small-scale

0.882

High

891453

UB2G2
Ubiquitin-conjugating enzyme E2 G2

8

0

Small-scale

0.717

High

1198721

SYVN1
E3 ubiquitin-protein ligase synoviolin

4

3

Small-scale

0.687

High

376523

APOB
Apolipoprotein B-100

4

0

Small-scale

0.670

High

1354377

SE1L1
Protein sel-1 homolog 1

4

0

Small-scale

0.661

High

875491

TERA
Transitional endoplasmic reticulum ATPase

3

0

Small-scale

0.628

High

229211

PRKN
E3 ubiquitin-protein ligase parkin

1

1

High-throughput

0.618

High

509756

UBL4A
Ubiquitin-like protein 4A

1

2

High-throughput

0.618

High

1274619

TP4A1
Protein tyrosine phosphatase type IVA 1

2

1

High-throughput

0.611

High

723122

OPRM
Mu-type opioid receptor

1

3

Small-scale

0.586

High

654943

CALX
Calnexin

2

0

High-throughput

0.585

High

1030660

CLN3
Battenin

2

0

Small-scale

0.585

High

350739

RASK
GTPase KRas

2

3

High-throughput

0.584

High

1356620

AMFR
E3 ubiquitin-protein ligase AMFR

2

2

Small-scale

0.584

High

1377550

UB2J1
Ubiquitin-conjugating enzyme E2 J1

2

2

Small-scale

0.584

High

1335894

GPR35
G-protein coupled receptor 35

2

6

High-throughput

0.578

High

439943

ITA2B
Integrin alpha-IIb

1

5

Small-scale

0.573

High

370828

ESR1
Estrogen receptor

2

2

High-throughput

0.571

High

391287

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

2

0

Small-scale

0.559

High

1088003

PTPRO
Receptor-type tyrosine-protein phosphatase O

2

0

High-throughput

0.559

High

1287238

FAF2
FAS-associated factor 2

2

0

Small-scale

0.559

High

172308

GP182
G-protein coupled receptor 182

1

5

High-throughput

0.536

High

531014

AT1A3
Sodium/potassium-transporting ATPase subunit alpha-3

1

2

High-throughput

0.536

High

976778

TAP1
Antigen peptide transporter 1

1

1

High-throughput

0.536

High

1199782

GPAT4
Glycerol-3-phosphate acyltransferase 4

1

1

High-throughput

0.536

High

1306456

CML1
Chemerin-like receptor 1

1

4

High-throughput

0.536

High

1333082

AT133
Polyamine-transporting ATPase 13A3

1

3

High-throughput

0.536

High

1350080

DIP2B
Disco-interacting protein 2 homolog B

1

1

High-throughput

0.536

High

781046

OPRK
Kappa-type opioid receptor

1

3

Small-scale

0.515

High

1033610

ILK
Integrin-linked protein kinase

1

1

High-throughput

0.515

High

1345105

TMPS4
Transmembrane protease serine 4

1

2

High-throughput

0.515

High

173790

SURF4
Surfeit locus protein 4

1

0

High-throughput

0.513

High

204095

HTRA2
Serine protease HTRA2, mitochondrial

1

0

High-throughput

0.513

High

237862

TSN3
Tetraspanin-3

1

0

High-throughput

0.513

High

505510

GTR1
Solute carrier family 2, facilitated glucose transporter member 1

1

0

High-throughput

0.513

High

529974

CFTR
Cystic fibrosis transmembrane conductance regulator

1

0

High-throughput

0.513

High

792871

EAA3
Excitatory amino acid transporter 3

1

0

High-throughput

0.513

High

944497

PRKDC
DNA-dependent protein kinase catalytic subunit

1

0

High-throughput

0.513

High

1047855

CKAP5
Cytoskeleton-associated protein 5

1

0

High-throughput

0.513

High

1233081

MFD4A
Major facilitator superfamily domain-containing protein 4A

1

0

High-throughput

0.513

High

1242368

LRN4L
LRRN4 C-terminal-like protein

1

0

High-throughput

0.513

High

1266071

AQP3
Aquaporin-3

1

0

High-throughput

0.513

High

1285166

LDAF1
Lipid droplet assembly factor 1

1

0

High-throughput

0.513

High

1328656

UN93B
Protein unc-93 homolog B1

1

0

High-throughput

0.513

High

1329727

SPNS1
Protein spinster homolog 1

1

0

High-throughput

0.513

High

1332048

SG196
Protein O-mannose kinase

1

0

High-throughput

0.513

High

1342292

ABCB6
ATP-binding cassette sub-family B member 6

1

0

High-throughput

0.513

High

1347202

TM248
Transmembrane protein 248

1

0

High-throughput

0.513

High

1377639

RNF11
RING finger protein 11

1

2

High-throughput

0.508

High

296784

ATG12
Ubiquitin-like protein ATG12

1

0

High-throughput

0.493

High

156967

FFAR1
Free fatty acid receptor 1

1

8

High-throughput

0.489

High

328423

S1PR4
Sphingosine 1-phosphate receptor 4

1

6

High-throughput

0.489

High

614174

TBG1
Tubulin gamma-1 chain

1

1

High-throughput

0.489

High

686410

VIPR1
Vasoactive intestinal polypeptide receptor 1

1

1

High-throughput

0.489

High

723442

APJ
Apelin receptor

1

4

High-throughput

0.489

High

783771

VIPR2
Vasoactive intestinal polypeptide receptor 2

1

1

High-throughput

0.489

High

813997

GPR12
G-protein coupled receptor 12

1

5

High-throughput

0.489

High

871989

AT12A
Potassium-transporting ATPase alpha chain 2

1

2

High-throughput

0.489

High

876217

PAR2
Proteinase-activated receptor 2

1

6

High-throughput

0.489

High

1067673

P2RY6
P2Y purinoceptor 6

1

7

High-throughput

0.489

High

1202766

P2RY8
P2Y purinoceptor 8

1

7

High-throughput

0.489

High

1297502

IMP1L
Mitochondrial inner membrane protease subunit 1

1

1

High-throughput

0.489

High

1302903

IMP2L
Mitochondrial inner membrane protease subunit 2

1

1

High-throughput

0.489

High

1335608

LPAR2
Lysophosphatidic acid receptor 2

1

6

High-throughput

0.489

High

1377402

GPR55
G-protein coupled receptor 55

1

10

High-throughput

0.489

High

1378146

GPR45
Probable G-protein coupled receptor 45

1

3

High-throughput

0.489

High

419252

ITAV
Integrin alpha-V

1

5

Small-scale

0.481

High

443112

ITA5
Integrin alpha-5

1

5

Small-scale

0.481

High

506146

ITAM
Integrin alpha-M

1

5

Small-scale

0.481

High

880225

ITA1
Integrin alpha-1

1

5

Small-scale

0.481

High

48570

ESYT2
Extended synaptotagmin-2

1

1

High-throughput

0.479

High

164056

AT2A1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1

1

1

High-throughput

0.479

High

168094

NPC1
NPC intracellular cholesterol transporter 1

1

1

High-throughput

0.479

High

178051

TMPS2
Transmembrane protease serine 2

1

2

High-throughput

0.479

High

178892

STX7
Syntaxin-7

1

1

High-throughput

0.479

High

349036

RASN
GTPase NRas

1

3

High-throughput

0.479

High

373171

HMDH
3-hydroxy-3-methylglutaryl-coenzyme A reductase

1

1

Small-scale

0.479

High

377840

GCR
Glucocorticoid receptor

1

2

High-throughput

0.479

High

436597

RHOC
Rho-related GTP-binding protein RhoC

1

7

High-throughput

0.479

High

507342

LAMP1
Lysosome-associated membrane glycoprotein 1

1

2

High-throughput

0.479

High

527917

LAMP2
Lysosome-associated membrane glycoprotein 2

1

2

High-throughput

0.479

High

545728

RAC2
Ras-related C3 botulinum toxin substrate 2

1

6

High-throughput

0.479

High

567352

CXA1
Gap junction alpha-1 protein

1

1

High-throughput

0.479

High

573990

PTN1
Tyrosine-protein phosphatase non-receptor type 1

1

1

High-throughput

0.479

High

591729

RAB3B
Ras-related protein Rab-3B

1

1

High-throughput

0.479

High

592617

RAB5A
Ras-related protein Rab-5A

1

2

High-throughput

0.479

High

595492

LMNB1
Lamin-B1

1

1

High-throughput

0.479

High

844815

RAB5C
Ras-related protein Rab-5C

1

2

High-throughput

0.479

High

845390

RAB7A
Ras-related protein Rab-7a

1

3

High-throughput

0.479

High

845833

RAB9A
Ras-related protein Rab-9A

1

3

High-throughput

0.479

High

892706

RAC3
Ras-related C3 botulinum toxin substrate 3

1

7

High-throughput

0.479

High

894637

CDC42
Cell division control protein 42 homolog

1

7

High-throughput

0.479

High

901101

RHOA
Transforming protein RhoA

1

8

High-throughput

0.479

High

916107

RHOB
Rho-related GTP-binding protein RhoB

1

8

High-throughput

0.479

High

925770

RAC1
Ras-related C3 botulinum toxin substrate 1

1

7

High-throughput

0.479

High

951500

RHOG
Rho-related GTP-binding protein RhoG

1

6

High-throughput

0.479

High

990761

CKAP4
Cytoskeleton-associated protein 4

1

1

High-throughput

0.479

High

1017864

STX4
Syntaxin-4

1

1

High-throughput

0.479

High

1070485

RAB35
Ras-related protein Rab-35

1

1

High-throughput

0.479

High

1076838

RHOH
Rho-related GTP-binding protein RhoH

1

8

High-throughput

0.479

High

1162150

RHDF2
Inactive rhomboid protein 2

1

1

High-throughput

0.479

High

1198240

TM11B
Transmembrane protease serine 11B

1

2

High-throughput

0.479

High

1204881

GOLI
E3 ubiquitin-protein ligase RNF130

1

2

High-throughput

0.479

High

1220718

MIRO2
Mitochondrial Rho GTPase 2

1

12

High-throughput

0.479

High

1244060

PCAT1
Lysophosphatidylcholine acyltransferase 1

1

1

Small-scale

0.479

High

1256095

RHBL4
Rhomboid-related protein 4

1

1

High-throughput

0.479

High

1259712

RN139
E3 ubiquitin-protein ligase RNF139

1

3

Small-scale

0.479

High

1282685

ERGI1
Endoplasmic reticulum-Golgi intermediate compartment protein 1

1

1

High-throughput

0.479

High

1296132

DNJC1
DnaJ homolog subfamily C member 1

1

2

High-throughput

0.479

High

1301263

ERGI2
Endoplasmic reticulum-Golgi intermediate compartment protein 2

1

1

High-throughput

0.479

High

1311471

ESYT1
Extended synaptotagmin-1

1

1

High-throughput

0.479

High

1316189

RNF26
E3 ubiquitin-protein ligase RNF26

1

1

High-throughput

0.479

High

1328902

DJC25
DnaJ homolog subfamily C member 25

1

1

High-throughput

0.479

High

1331015

RHOJ
Rho-related GTP-binding protein RhoJ

1

8

High-throughput

0.479

High

1335426

RHOF
Rho-related GTP-binding protein RhoF

1

9

High-throughput

0.479

High

1357157

CLC4E
C-type lectin domain family 4 member E

1

1

High-throughput

0.479

High

1304972

NECD
Necdin

1

1

High-throughput

0.470

High

149474

CTRO
Citron Rho-interacting kinase

1

0

High-throughput

0.458

High

174177

SPTC1
Serine palmitoyltransferase 1

1

0

Small-scale

0.458

High

274051

NU155
Nuclear pore complex protein Nup155

1

0

High-throughput

0.458

High

390646

RPN1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

1

0

High-throughput

0.458

High

411909

LCK
Tyrosine-protein kinase Lck

1

0

High-throughput

0.458

High

545062

AMPN
Aminopeptidase N

1

0

High-throughput

0.458

High

554180

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.458

High

670306

MARCS
Myristoylated alanine-rich C-kinase substrate

1

0

High-throughput

0.458

High

719276

PHB1
Prohibitin 1

1

0

High-throughput

0.458

High

763147

OST48
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit

1

0

Small-scale

0.458

High

786210

LAP2B
Lamina-associated polypeptide 2, isoforms beta/gamma

1

0

High-throughput

0.458

High

795352

SSRA
Translocon-associated protein subunit alpha

1

0

High-throughput

0.458

High

815836

SC6A8
Sodium- and chloride-dependent creatine transporter 1

1

0

Small-scale

0.458

High

825615

LMAN1
Protein ERGIC-53

1

0

High-throughput

0.458

High

839256

EMD
Emerin

1

0

High-throughput

0.458

High

847743

BAP31
B-cell receptor-associated protein 31

1

0

High-throughput

0.458

High

881705

PEX3
Peroxisomal biogenesis factor 3

1

0

High-throughput

0.458

High

890543

SC61B
Protein transport protein Sec61 subunit beta

1

0

High-throughput

0.458

High

913218

ARF6
ADP-ribosylation factor 6

1

0

High-throughput

0.458

High

914496

RB11A
Ras-related protein Rab-11A

1

0

High-throughput

0.458

High

918225

H4
Histone H4

1

0

High-throughput

0.458

High

961896

REEP5
Receptor expression-enhancing protein 5

1

0

High-throughput

0.458

High

965921

IFM3
Interferon-induced transmembrane protein 3

1

0

High-throughput

0.458

High

1030076

TIF1B
Transcription intermediary factor 1-beta

1

0

High-throughput

0.458

High

1034572

OS9
Protein OS-9

1

0

Small-scale

0.458

High

1040315

STIM1
Stromal interaction molecule 1

1

0

High-throughput

0.458

High

1042952

CUL3
Cullin-3

1

0

High-throughput

0.458

High

1053273

FKBP8
Peptidyl-prolyl cis-trans isomerase FKBP8

1

0

High-throughput

0.458

High

1066958

KIF14
Kinesin-like protein KIF14

1

0

High-throughput

0.458

High

1087644

CAH9
Carbonic anhydrase 9

1

0

High-throughput

0.458

High

1135174

ACBD5
Acyl-CoA-binding domain-containing protein 5

1

0

High-throughput

0.458

High

1166117

LMBRL
Protein LMBR1L

1

0

High-throughput

0.458

High

1221016

FA20C
Extracellular serine/threonine protein kinase FAM20C

1

0

High-throughput

0.458

High

1240379

DHB11
Estradiol 17-beta-dehydrogenase 11

1

0

High-throughput

0.458

High

1243469

PDZD8
PDZ domain-containing protein 8

1

0

High-throughput

0.458

High

1253706

STT3B
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B

1

0

Small-scale

0.458

High

1268044

EDEM1
ER degradation-enhancing alpha-mannosidase-like protein 1

1

0

High-throughput

0.458

High

1269001

AKAP1
A-kinase anchor protein 1, mitochondrial

1

0

High-throughput

0.458

High

1284200

LRC59
Leucine-rich repeat-containing protein 59

1

0

High-throughput

0.458

High

1300823

PANX1
Pannexin-1

1

0

High-throughput

0.458

High

1303653

SEC62
Translocation protein SEC62

1

0

High-throughput

0.458

High

1313121

DERL1
Derlin-1

1

0

High-throughput

0.458

High

1319302

LNP
Endoplasmic reticulum junction formation protein lunapark

1

0

High-throughput

0.458

High

1329340

3BHS7
3 beta-hydroxysteroid dehydrogenase type 7

1

0

High-throughput

0.458

High

1333633

TMT1A
Thiol S-methyltransferase TMT1A

1

0

High-throughput

0.458

High

1344354

PXMP2
Peroxisomal membrane protein 2

1

0

High-throughput

0.458

High

1344485

ST7
Suppressor of tumorigenicity 7 protein

1

0

High-throughput

0.458

High

1344638

FBX6
F-box only protein 6

1

0

High-throughput

0.458

High

1348628

ELOV5
Very long chain fatty acid elongase 5

1

0

High-throughput

0.458

High

1349731

TM216
Transmembrane protein 216

1

0

High-throughput

0.458

High

1350599

B3GA1
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1

1

0

High-throughput

0.458

High

1355180

SEC63
Translocation protein SEC63 homolog

1

0

High-throughput

0.458

High

1203598

STING
Stimulator of interferon genes protein

1

1

Small-scale

0.445

High

566912

ITA2
Integrin alpha-2

1

5

Small-scale

0.439

High

120740

RHOD
Rho-related GTP-binding protein RhoD

1

10

High-throughput

0.437

High

360591

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

1

High-throughput

0.437

High

781038

OPRD
Delta-type opioid receptor

1

3

Small-scale

0.437

High

795936

MAGA6
Melanoma-associated antigen 6

1

1

High-throughput

0.437

High

852697

RND2
Rho-related GTP-binding protein RhoN

1

10

High-throughput

0.437

High

909414

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

1

High-throughput

0.437

High

999264

EP300
Histone acetyltransferase p300

1

1

High-throughput

0.437

High

1110136

AR13B
ADP-ribosylation factor-like protein 13B

1

1

High-throughput

0.437

High

1156760

TECT3
Tectonic-3

1

1

High-throughput

0.437

High

1222132

S15A3
Solute carrier family 15 member 3

1

1

High-throughput

0.437

High

1230446

CXD3
Gap junction delta-3 protein

1

1

High-throughput

0.437

High

1263942

CLC4D
C-type lectin domain family 4 member D

1

1

High-throughput

0.437

High

1270047

ESR2
Estrogen receptor beta

1

2

High-throughput

0.437

High

1292913

TECT2
Tectonic-2

1

1

High-throughput

0.437

High

1357946

LAMP3
Lysosome-associated membrane glycoprotein 3

1

2

High-throughput

0.437

High

575882

VINC
Vinculin

1

0

High-throughput

0.426

High

1241700

MOT11
Monocarboxylate transporter 11

1

0

High-throughput

0.426

High

1329446

S38A1
Sodium-coupled neutral amino acid symporter 1

1

0

High-throughput

0.426

High

1347538

CLN6
Ceroid-lipofuscinosis neuronal protein 6

1

0

Small-scale

0.426

High

99708

F5H1C8
Solute carrier family 15 member 3

1

1

High-throughput

0.407

High

826498

FNTB
Protein farnesyltransferase subunit beta

3

0

High-throughput

0.347

High

1063135

ABRX2
BRISC complex subunit Abraxas 2

3

0

High-throughput

0.347

High

1377921

RN114
E3 ubiquitin-protein ligase RNF114

3

0

High-throughput

0.347

High

348383

MYC
Myc proto-oncogene protein

2

0

High-throughput

0.305

High

1057040

MDC1
Mediator of DNA damage checkpoint protein 1

1

0

High-throughput

0.288

High

245451

RAMP3
Receptor activity-modifying protein 3

1

0

High-throughput

0.279

Low

1152857

CAPR2
Caprin-2

1

0

High-throughput

0.279

Low

1219159

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

0

High-throughput

0.279

Low

1309550

TBA1C
Tubulin alpha-1C chain

1

0

High-throughput

0.279

Low

1018144

GRSF1
G-rich sequence factor 1

1

0

Small-scale

0.251

Low

206233

TGON2
Trans-Golgi network integral membrane protein 2

1

0

High-throughput

0.249

Low

385809

NTRK1
High affinity nerve growth factor receptor

1

0

High-throughput

0.249

Low

652739

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.249

Low

721909

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

780410

CCNF
Cyclin-F

1

0

High-throughput

0.249

Low

941635

RNF4
E3 ubiquitin-protein ligase RNF4

1

0

High-throughput

0.249

Low

1036258

BIRC3
Baculoviral IAP repeat-containing protein 3

1

0

High-throughput

0.249

Low

1088060

DUS6
Dual specificity protein phosphatase 6

1

0

High-throughput

0.249

Low

1101404

CL16A
Protein CLEC16A

1

0

High-throughput

0.249

Low

1116917

ACSF3
Malonate--CoA ligase ACSF3, mitochondrial

1

0

Small-scale

0.249

Low

1172472

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

1200877

PAQR2
Adiponectin receptor protein 2

1

0

Small-scale

0.249

Low

1203927

TMM17
Transmembrane protein 17

1

0

High-throughput

0.249

Low

1204379

DYR2
Dihydrofolate reductase 2, mitochondrial

1

0

High-throughput

0.249

Low

1244777

NUP35
Nucleoporin NUP35

1

0

High-throughput

0.249

Low

1252055

DPTOR
DEP domain-containing mTOR-interacting protein

1

0

Small-scale

0.249

Low

1281892

FBX32
F-box only protein 32

1

0

High-throughput

0.249

Low

1283989

S2546
Mitochondrial outer membrane protein SLC25A46

1

0

High-throughput

0.249

Low

1303214

RMD3
Regulator of microtubule dynamics protein 3

1

0

High-throughput

0.249

Low

1331760

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.249

Low

1332838

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.249

Low

1334994

BRF2
Transcription factor IIIB 50 kDa subunit

1

0

High-throughput

0.249

Low

1343418

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

0

Small-scale

0.249

Low

1346225

OTULL
Inactive ubiquitin thioesterase OTULINL

1

0

High-throughput

0.249

Low

1346368

PCMD2
Protein-L-isoaspartate O-methyltransferase domain-containing protein 2

1

0

High-throughput

0.249

Low

1347005

KBTB4
Kelch repeat and BTB domain-containing protein 4

1

0

High-throughput

0.249

Low

1355036

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.249

Low

1356237

KCND3
Potassium voltage-gated channel subfamily D member 3

1

0

Small-scale

0.249

Low

1356388

FBW1B
F-box/WD repeat-containing protein 11

1

0

High-throughput

0.249

Low

1378175

KPTN
KICSTOR complex protein kaptin

1

0

High-throughput

0.249

Low

1282370

UB2E3
Ubiquitin-conjugating enzyme E2 E3

1

0

High-throughput

0.238

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024