HitPredict

Interactor 1: HS90A (P07900)
Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86) (Heat shock protein family C member 1) (Lipopolysaccharide-associated protein 2) (LAP-2) (LPS-associated protein 2) (Renal carcinoma antigen NY-REN-38)
Gene: HSP90AA1

Interactor 2: RIPK4 (P57078)
Receptor-interacting serine/threonine-protein kinase 4 (EC 2.7.11.1) (Ankyrin repeat domain-containing protein 3) (PKC-delta-interacting protein kinase)
Gene: RIPK4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	26972000
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	HSP90~Pkinase
Common GO terms	GO:0005524 - ATP binding GO:0005737 - cytoplasm GO:0016020 - membrane
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 732 Hs			1 832
+	Hs
		432263 HS90A_HUMAN (1-732): 0: 1087: 100.00		Q9H4D1_HUMAN (1-832): 0: 697: 90.75
+	Hs
		432186 HS90A_HUMAN (1-732): 0: 1087: 100.00		Q96T11_HUMAN (1-832): 0: 691: 90.51
+	Hs
		438529 HS90B_HUMAN (19-732): 0: 1059: 86.13		Q9H4D1_HUMAN (1-832): 0: 697: 90.75
+	Hs
		538174 ENPL_HUMAN (14-701): 0: 898: 46.78		RIPK4_HUMAN (1-832): 0: 726: 100.00
+	Hs
		538399 ENPL_HUMAN (14-701): 0: 898: 46.78		Q9H4D1_HUMAN (1-832): 0: 697: 90.75
+	Hs
		431682 HS90A_HUMAN (1-732): 0: 1087: 100.00		DAPK1_HUMAN (513-831): 7.19e-83: 292: 25.16
+	Hs
		438082 HS90B_HUMAN (19-732): 0: 1059: 86.13		ANK2_HUMAN (592-832): 1.31e-65: 241: 27.89
+	Hs
		201744 HS90A_HUMAN (1-732): 0: 1087: 100.00		RIPK2_HUMAN (31-276): 6.59e-54: 197: 44.94
+	Hs
		432073 HS90A_HUMAN (1-732): 0: 1087: 100.00		ANKK1_HUMAN (342-643): 1.15e-46: 180: 19.47
+	Hs
		438365 HS90B_HUMAN (19-732): 0: 1059: 86.13		ANKK1_HUMAN (342-643): 1.15e-46: 180: 19.47
+	Hs
		438117 HS90B_HUMAN (19-732): 0: 1059: 86.13		ANK3_HUMAN (659-832): 4.77e-45: 178: 32.57
+	Hs
		432396 HS90A_HUMAN (1-732): 0: 1087: 100.00		RIPK3_HUMAN (21-371): 4.07e-34: 139: 30.39
+	Hs
		431824 HS90A_HUMAN (1-732): 0: 1087: 100.00		RIPK1_HUMAN (19-278): 1.18e-32: 137: 34.31
+	Hs
		438651 HS90B_HUMAN (19-732): 0: 1059: 86.13		RIPK3_HUMAN (21-371): 4.07e-34: 139: 30.39
+	Hs
		438144 HS90B_HUMAN (19-732): 0: 1059: 86.13		RIPK1_HUMAN (19-278): 1.18e-32: 137: 34.31
+	Hs
		1123425 H90B4_HUMAN (30-604): 0: 571: 62.61		ANKK1_HUMAN (342-643): 1.15e-46: 180: 19.47