Protein: ITB5
Integrin beta-5

Gene: ITB5, ITGB5
Organism: Homo sapiens
Interactions: 133
UniProt ID: P18084

Gene Ontology (top 5):
GO:0001618 - virus receptor activity
GO:0005178 - integrin binding
GO:0005886 - plasma membrane
GO:0005925 - focal adhesion
GO:0007160 - cell-matrix adhesion

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

447975

ITAV
Integrin alpha-V

3

20

Small-scale

0.847

High

612100

TITIN
Titin

1

9

High-throughput

0.698

High

612042

CEAM8
Cell adhesion molecule CEACAM8

1

7

High-throughput

0.691

High

612046

I12R1
Interleukin-12 receptor subunit beta-1

1

8

High-throughput

0.691

High

612124

BTNL2
Butyrophilin-like protein 2

1

5

High-throughput

0.691

High

399542

VTNC
Vitronectin

4

4

Small-scale

0.691

High

229865

EDIL3
EGF-like repeat and discoidin I-like domain-containing protein 3

3

11

High-throughput

0.667

High

612070

MFGM
Lactadherin

3

7

High-throughput

0.667

High

612127

ADA21
Disintegrin and metalloproteinase domain-containing protein 21

2

12

High-throughput

0.628

High

612079

MYPC2
Myosin-binding protein C, fast-type

1

6

High-throughput

0.625

High

612066

FAK1
Focal adhesion kinase 1

2

20

Small-scale

0.624

High

389005

FINC
Fibronectin

1

14

Small-scale

0.618

High

473656

ITA5
Integrin alpha-5

1

20

Small-scale

0.618

High

612037

ITA3
Integrin alpha-3

1

20

Small-scale

0.618

High

612040

EPHA2
Ephrin type-A receptor 2

1

12

Small-scale

0.618

High

612047

MUC18
Cell surface glycoprotein MUC18

1

5

High-throughput

0.618

High

612048

DCC
Netrin receptor DCC

1

6

Small-scale

0.618

High

612130

TLN2
Talin-2

1

18

Small-scale

0.618

High

612129

KLK5
Kallikrein-5

3

5

High-throughput

0.609

High

70111

CRTP1
Cysteine-rich tail protein 1

2

2

High-throughput

0.606

High

351502

FBLN4
EGF-containing fibulin-like extracellular matrix protein 2

2

6

High-throughput

0.606

High

612078

FHL3
Four and a half LIM domains protein 3

2

9

High-throughput

0.606

High

612080

K1H1
Keratin, type I cuticular Ha1

2

6

High-throughput

0.606

High

480693

LEG1
Galectin-1

2

16

High-throughput

0.601

High

612054

KR108
Keratin-associated protein 10-8

3

20

High-throughput

0.597

High

612055

KR109
Keratin-associated protein 10-9

3

19

High-throughput

0.597

High

612084

MTUS2
Microtubule-associated tumor suppressor candidate 2

3

7

High-throughput

0.597

High

612108

TIMD4
T-cell immunoglobulin and mucin domain-containing protein 4

1

0

Small-scale

0.586

High

612049

AT1B3
Sodium/potassium-transporting ATPase subunit beta-3

2

0

High-throughput

0.585

High

532345

CH60
60 kDa heat shock protein, mitochondrial

2

3

High-throughput

0.584

High

612058

RB11A
Ras-related protein Rab-11A

2

3

High-throughput

0.584

High

612101

SIA8D
CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase

2

3

High-throughput

0.574

High

612116

ADA33
Disintegrin and metalloproteinase domain-containing protein 33

2

12

High-throughput

0.574

High

354531

PAK4
Serine/threonine-protein kinase PAK 4

1

4

Small-scale

0.573

High

476082

ANXA5
Annexin A5

1

1

Small-scale

0.561

High

612093

FRMD5
FERM domain-containing protein 5

1

6

Small-scale

0.561

High

612098

STAB2
Stabilin-2

1

12

Small-scale

0.561

High

612121

MYO10
Unconventional myosin-X

1

6

Small-scale

0.561

High

300297

KRT34
Keratin, type I cuticular Ha4

2

6

High-throughput

0.553

High

612053

KR107
Keratin-associated protein 10-7

2

19

High-throughput

0.553

High

612068

KRA11
Keratin-associated protein 1-1

2

20

High-throughput

0.553

High

612069

GOGA2
Golgin subfamily A member 2

2

7

High-throughput

0.553

High

612088

KRA57
Keratin-associated protein 5-7

2

19

High-throughput

0.553

High

612094

KRA13
Keratin-associated protein 1-3

2

20

High-throughput

0.553

High

612103

APBP2
Amyloid protein-binding protein 2

2

4

High-throughput

0.553

High

612114

KRA32
Keratin-associated protein 3-2

2

1

High-throughput

0.553

High

612091

TRI67
Tripartite motif-containing protein 67

1

8

High-throughput

0.553

High

612099

PATE1
Prostate and testis expressed protein 1

2

1

High-throughput

0.549

High

612125

FBX2
F-box only protein 2

2

12

High-throughput

0.549

High

399431

TRGV3
T cell receptor gamma variable 3

1

0

High-throughput

0.546

High

408661

G3P
Glyceraldehyde-3-phosphate dehydrogenase

1

1

High-throughput

0.541

High

341284

ECEL1
Endothelin-converting enzyme-like 1

1

3

High-throughput

0.536

High

612036

PRTN3
Myeloblastin

1

6

High-throughput

0.536

High

612038

NKG2A
NKG2-A/NKG2-B type II integral membrane protein

1

13

High-throughput

0.536

High

612039

CALX
Calnexin

1

9

High-throughput

0.536

High

612041

PDIA3
Protein disulfide-isomerase A3

1

5

Small-scale

0.536

High

612067

NKG2E
NKG2-E type II integral membrane protein

1

13

High-throughput

0.536

High

612096

LYPD1
Ly6/PLAUR domain-containing protein 1

1

1

High-throughput

0.536

High

612102

CLC2B
C-type lectin domain family 2 member B

1

13

High-throughput

0.536

High

612105

T106A
Transmembrane protein 106A

1

1

High-throughput

0.536

High

612117

CNTP3
Contactin-associated protein-like 3

1

16

High-throughput

0.536

High

612126

ADA30
Disintegrin and metalloproteinase domain-containing protein 30

1

12

High-throughput

0.536

High

612092

NT2NA
Notch homolog 2 N-terminal-like protein A

2

15

High-throughput

0.533

High

612075

SNTA1
Alpha-1-syntrophin

1

3

Small-scale

0.527

High

612044

FDFT
Squalene synthase

1

0

High-throughput

0.518

High

389955

ALBU
Albumin

1

0

High-throughput

0.513

High

438867

CD1A
T-cell surface glycoprotein CD1a

1

0

High-throughput

0.513

High

612107

ASIC4
Acid-sensing ion channel 4

1

0

High-throughput

0.513

High

612120

LRRC4
Leucine-rich repeat-containing protein 4

1

0

High-throughput

0.513

High

612104

TRI63
E3 ubiquitin-protein ligase TRIM63

1

8

High-throughput

0.504

High

522238

OSTP
Osteopontin

1

1

Small-scale

0.501

High

612071

EPS8
Epidermal growth factor receptor kinase substrate 8

1

7

Small-scale

0.501

High

612085

TENS2
Tensin-2

1

6

Small-scale

0.501

High

612035

TAF1
Transcription initiation factor TFIID subunit 1

1

2

High-throughput

0.494

High

612082

GON4L
GON-4-like protein

1

1

High-throughput

0.494

High

612115

TRI55
Tripartite motif-containing protein 55

1

8

High-throughput

0.494

High

191431

SIA8E
Alpha-2,8-sialyltransferase 8E

1

3

High-throughput

0.489

High

209371

SIA8C
Alpha-N-acetylneuraminate alpha-2,8-sialyltransferase ST8SIA3

1

3

High-throughput

0.489

High

612083

GXLT1
Glucoside xylosyltransferase 1

1

1

High-throughput

0.489

High

612089

BRID5
BRICHOS domain-containing protein 5

1

1

High-throughput

0.489

High

612118

KLK15
Kallikrein-15

1

7

High-throughput

0.489

High

612128

PRG3
Proteoglycan 3

1

5

High-throughput

0.489

High

2090

TVA20
T cell receptor alpha variable 20

1

0

High-throughput

0.481

High

612064

EWS
RNA-binding protein EWS

1

4

High-throughput

0.481

High

142049

CCN1
CCN family member 1

1

0

Small-scale

0.480

High

154462

CLD4
Claudin-4

1

1

Small-scale

0.479

High

189411

STX7
Syntaxin-7

1

2

High-throughput

0.479

High

217807

TGON2
Trans-Golgi network integral membrane protein 2

1

11

High-throughput

0.479

High

375159

RASK
GTPase KRas

1

15

High-throughput

0.479

High

466101

RHOC
Rho-related GTP-binding protein RhoC

1

20

High-throughput

0.479

High

555809

ACE
Angiotensin-converting enzyme

1

3

Small-scale

0.479

High

563153

CFTR
Cystic fibrosis transmembrane conductance regulator

1

6

High-throughput

0.479

High

580866

RAC2
Ras-related C3 botulinum toxin substrate 2

1

18

High-throughput

0.479

High

612034

RAB4A
Ras-related protein Rab-4A

1

6

High-throughput

0.479

High

612043

TSP4
Thrombospondin-4

1

10

Small-scale

0.479

High

612045

BCL6
B-cell lymphoma 6 protein

1

1

High-throughput

0.479

High

612050

RAB25
Ras-related protein Rab-25

1

3

High-throughput

0.479

High

612056

RAB2A
Ras-related protein Rab-2A

1

6

High-throughput

0.479

High

612057

ARF6
ADP-ribosylation factor 6

1

1

High-throughput

0.479

High

612059

RHOB
Rho-related GTP-binding protein RhoB

1

20

High-throughput

0.479

High

612060

RAC1
Ras-related C3 botulinum toxin substrate 1

1

20

High-throughput

0.479

High

612076

ADAM9
Disintegrin and metalloproteinase domain-containing protein 9

1

9

Small-scale

0.479

High

612077

CUL3
Cullin-3

1

5

High-throughput

0.479

High

612106

FERM2
Fermitin family homolog 2

1

17

Small-scale

0.479

High

612113

ACE2
Angiotensin-converting enzyme 2

1

3

Small-scale

0.479

High

612119

RHOJ
Rho-related GTP-binding protein RhoJ

1

20

High-throughput

0.479

High

612123

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.479

High

516963

NT2NC
Notch homolog 2 N-terminal-like protein C

1

15

High-throughput

0.470

High

123327

BACH
Cytosolic acyl coenzyme A thioester hydrolase

1

0

High-throughput

0.458

High

612052

MYPR
Myelin proteolipid protein

1

0

Small-scale

0.458

High

612090

BAKOR
Beclin 1-associated autophagy-related key regulator

1

0

High-throughput

0.458

High

612112

ANGL4
Angiopoietin-related protein 4

1

4

Small-scale

0.457

High

612061

RACK1
Small ribosomal subunit protein RACK1

1

5

Small-scale

0.457

High

612051

CD81
CD81 antigen

1

19

High-throughput

0.445

High

612063

BAT1
b(0,+)-type amino acid transporter 1

1

2

High-throughput

0.445

High

612081

MICB
MHC class I polypeptide-related sequence B

1

2

High-throughput

0.445

High

478

NBPFJ
NBPF family member NBPF19

1

7

High-throughput

0.439

High

612065

PPARD
Peroxisome proliferator-activated receptor delta

1

1

High-throughput

0.439

High

612073

SRSF9
Serine/arginine-rich splicing factor 9

1

1

High-throughput

0.439

High

612087

K1C40
Keratin, type I cytoskeletal 40

1

6

High-throughput

0.439

High

612109

EHMT2
Histone-lysine N-methyltransferase EHMT2

1

4

High-throughput

0.439

High

370150

CYTN
Cystatin-SN

1

3

Small-scale

0.437

High

612062

RNF4
E3 ubiquitin-protein ligase RNF4

1

1

High-throughput

0.437

High

612074

CENPR
Centromere protein R

1

1

Small-scale

0.437

High

612086

A16L1
Autophagy-related protein 16-1

1

2

High-throughput

0.437

High

612111

SEC62
Translocation protein SEC62

1

1

High-throughput

0.437

High

612122

FBX6
F-box only protein 6

1

12

High-throughput

0.437

High

612110

VPS35
Vacuolar protein sorting-associated protein 35

1

0

Small-scale

0.426

High

170654

CLGN
Calmegin

1

9

High-throughput

0.407

High

612097

ZN655
Zinc finger protein 655

2

0

High-throughput

0.316

High

612131

INSL5
Insulin-like peptide INSL5

1

0

High-throughput

0.279

Low

612072

ZBT17
Zinc finger and BTB domain-containing protein 17

1

0

Small-scale

0.251

Low

612095

CUL9
Cullin-9

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025