HitPredict

Interactor 1: HS90A (P07900)
Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86) (Heat shock protein family C member 1) (Lipopolysaccharide-associated protein 2) (LAP-2) (LPS-associated protein 2) (Renal carcinoma antigen NY-REN-38)
Gene: HSP90AA1

Interactor 2: SIM1 (P81133)
Single-minded homolog 1 (Class E basic helix-loop-helix protein 14) (bHLHe14)
Gene: SIM1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	9020169
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 732 Hs			1 766
+	Mm
		432429 HS90A_MOUSE (1-732): 0: 1083: 97.82		SIM1_MOUSE (1-766): 0: 854: 96.61
+	Hs
		431844 HS90A_HUMAN (1-732): 0: 1087: 100.00		SIM2_HUMAN (1-654): 1.45e-165: 495: 55.74
+	Hs
		432201 HS90A_HUMAN (1-732): 0: 1087: 100.00		EPAS1_HUMAN (2-678): 1.38e-156: 479: 23.31
+	Hs
		438165 HS90B_HUMAN (19-732): 0: 1059: 86.13		SIM2_HUMAN (1-654): 1.45e-165: 495: 55.74
+	Hs
		431556 HS90A_HUMAN (1-732): 0: 1087: 100.00		ARNT_HUMAN (2-664): 3.58e-151: 462: 17.94
+	Hs
		431903 HS90A_HUMAN (1-732): 0: 1087: 100.00		HIF1A_HUMAN (2-477): 8.92e-145: 447: 31.31
+	Mm
		432431 HS90A_MOUSE (1-732): 0: 1083: 97.82		HIF1A_MOUSE (2-482): 6.3e-144: 445: 31.46
+	Hs
		432385 HS90A_HUMAN (1-732): 0: 1087: 100.00		HIF3A_HUMAN (2-643): 4.4e-142: 434: 26.92
+	Hs
		438217 HS90B_HUMAN (19-732): 0: 1059: 86.13		HIF1A_HUMAN (2-477): 8.92e-145: 447: 31.31
+	Hs
		126097 HS90A_HUMAN (1-732): 0: 1087: 100.00		BMAL1_HUMAN (2-490): 1.58e-130: 403: 23.26
+	Mm
		432410 HS90A_MOUSE (1-732): 0: 1083: 97.82		AHR_MOUSE (5-711): 7.36e-117: 374: 19.97
+	Hs
		431594 HS90A_HUMAN (1-732): 0: 1087: 100.00		AHR_HUMAN (5-484): 9.47e-113: 363: 20.04
+	Rn
		783943 HS90A_RAT (1-732): 0: 1085: 97.95		AHR_RAT (5-649): 2.01e-112: 363: 18.61
+	Hs
		438468 HS90B_HUMAN (19-732): 0: 1059: 86.13		NPAS1_HUMAN (2-492): 1.78e-121: 378: 31.42
+	Mm
		513659 HS90B_MOUSE (19-732): 0: 1063: 86.98		AHR_MOUSE (5-711): 7.36e-117: 374: 19.97
+	Hs
		432199 HS90A_HUMAN (1-732): 0: 1087: 100.00		NPAS2_HUMAN (2-443): 6.03e-95: 315: 21.15
+	Dm
		1096504 Q9VAY2_DROME (15-700): 0: 537: 46.13		SIMA_DROME (2-418): 2.01e-98: 335: 29.39