HitPredict

Interactor 1: HS90A (P07900)
Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86) (Heat shock protein family C member 1) (Lipopolysaccharide-associated protein 2) (LAP-2) (LPS-associated protein 2) (Renal carcinoma antigen NY-REN-38)
Gene: HSP90AA1

Interactor 2: M3K1 (Q13233)
Mitogen-activated protein kinase kinase kinase 1 (EC 2.7.11.25) (MAPK/ERK kinase kinase 1) (MEK kinase 1) (MEKK 1) (EC 2.3.2.27)
Gene: MAP3K1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	14743216
Identification Methods	tandem affinity purification
Interaction Type	physical association

Property	Details
Interacting Pfam domains	HSP90~Pkinase
Common GO terms	GO:0005524 - ATP binding GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 732 Hs			1 1512
+	Hs
		438130 HS90B_HUMAN (19-732): 0: 1059: 86.13		M3K1_HUMAN (1-1512): 0: 1994: 100.00
+	Hs
		431895 HS90A_HUMAN (1-732): 0: 1087: 100.00		PKN2_HUMAN (785-1509): 6.77e-150: 485: 16.27
+	Hs
		431510 HS90A_HUMAN (1-732): 0: 1087: 100.00		KPCA_HUMAN (963-1509): 9.28e-133: 428: 18.93
+	Hs
		408527 HS90A_HUMAN (1-732): 0: 1087: 100.00		KPCB_HUMAN (899-1509): 2.67e-127: 413: 15.40
+	Hs
		431868 HS90A_HUMAN (1-732): 0: 1087: 100.00		KPCD1_HUMAN (852-1510): 2.29e-124: 413: 16.89
+	Hs
		431913 HS90A_HUMAN (1-732): 0: 1087: 100.00		MYLK3_HUMAN (792-1510): 2.74e-124: 410: 15.35
+	Hs
		431894 HS90A_HUMAN (1-732): 0: 1087: 100.00		PKN1_HUMAN (777-1512): 3.49e-122: 407: 14.62
+	Hs
		397123 HS90A_HUMAN (1-732): 0: 1087: 100.00		KPCG_HUMAN (899-1509): 4.13e-124: 405: 16.04
+	Hs
		437869 HS90B_HUMAN (19-732): 0: 1059: 86.13		KPCA_HUMAN (963-1509): 9.28e-133: 428: 18.93
+	Hs
		408529 HS90B_HUMAN (19-732): 0: 1059: 86.13		KPCB_HUMAN (899-1509): 2.67e-127: 413: 15.40
+	Hs
		432057 HS90A_HUMAN (1-732): 0: 1087: 100.00		DCLK2_HUMAN (996-1508): 3.42e-114: 380: 16.03
+	Hs
		397124 HS90B_HUMAN (19-732): 0: 1059: 86.13		KPCG_HUMAN (899-1509): 4.13e-124: 405: 16.04
+	Hs
		431741 HS90A_HUMAN (1-732): 0: 1087: 100.00		CDK3_HUMAN (1243-1510): 4.87e-105: 338: 27.21
+	Hs
		431549 HS90A_HUMAN (1-732): 0: 1087: 100.00		CDK2_HUMAN (1243-1509): 1.1e-104: 337: 25.85
+	Hs
		438075 HS90B_HUMAN (19-732): 0: 1059: 86.13		CDK3_HUMAN (1243-1510): 4.87e-105: 338: 27.21
+	Hs
		437908 HS90B_HUMAN (19-732): 0: 1059: 86.13		CDK2_HUMAN (1243-1509): 1.1e-104: 337: 25.85
+	Hs
		432200 HS90A_HUMAN (1-732): 0: 1087: 100.00		M3K3_HUMAN (1243-1505): 1.2e-51: 195: 44.03
+	Hs
		432386 HS90A_HUMAN (1-732): 0: 1087: 100.00		M3K2_HUMAN (1238-1505): 3.52e-50: 191: 42.13
+	Hs
		431980 HS90A_HUMAN (1-732): 0: 1087: 100.00		M3K15_HUMAN (1249-1509): 4.63e-42: 171: 36.84
+	Hs
		432196 HS90A_HUMAN (1-732): 0: 1087: 100.00		M3K5_HUMAN (1249-1503): 1.95e-40: 166: 37.31