HitPredict

Interactor 1: HS90A (P07900)
Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86) (Heat shock protein family C member 1) (Lipopolysaccharide-associated protein 2) (LAP-2) (LPS-associated protein 2) (Renal carcinoma antigen NY-REN-38)
Gene: HSP90AA1

Interactor 2: FKBP5 (Q13451)
Peptidyl-prolyl cis-trans isomerase FKBP5 (PPIase FKBP5) (EC 5.2.1.8) (51 kDa FK506-binding protein) (51 kDa FKBP) (FKBP-51) (54 kDa progesterone receptor-associated immunophilin) (Androgen-regulated protein 6) (FF1 antigen) (FK506-binding protein 5) (FKBP-5) (FKBP54) (p54) (HSP90-binding immunophilin) (Rotamase)
Gene: FKBP5

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.96	1.00	0.982

Property	Details
Experiments	20048054, 23999428, 20661446, 19875381, 21360678, 10642522, 28363942, 9001212, 35271311, 21170051, 21235734, 25036637, 29079741
Identification Methods	affinity chromatography technology, pull down, x-ray crystallography, differential scanning calorimetry, tandem affinity purification, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	FKBP_C~HSP90
Common GO terms	GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0006457 - protein folding GO:0016020 - membrane and 1 others more... GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 732 Hs			1 457
+	Hs
		111937 K9JA46_HUMAN (1-732): 0: 1087: 100.00		FKBP5_HUMAN (1-457): 6.63e-145: 423: 100.00
+	Hs
		111936 K9JA46_HUMAN (1-732): 0: 1087: 100.00		FKBP4_HUMAN (1-456): 1.79e-136: 402: 54.59
+	Hs
		431755 HS90A_HUMAN (1-732): 0: 1087: 100.00		FKBP4_HUMAN (1-456): 1.79e-136: 402: 54.59
+	Mm
		432409 HS90A_MOUSE (1-732): 0: 1083: 97.82		FKBP4_MOUSE (1-444): 7.18e-136: 400: 55.38
+	Hs
		438089 HS90B_HUMAN (19-732): 0: 1059: 86.13		FKBP4_HUMAN (1-456): 1.79e-136: 402: 54.59
+	Hs
		111943 K9JA46_HUMAN (1-732): 0: 1087: 100.00		FKBPL_HUMAN (133-414): 4.04e-51: 178: 25.70
+	Hs
		431781 HS90A_HUMAN (1-732): 0: 1087: 100.00		PPID_HUMAN (249-414): 4.11e-51: 178: 24.55
+	Hs
		432312 HS90A_HUMAN (1-732): 0: 1087: 100.00		AIPL1_HUMAN (125-419): 6.14e-51: 178: 19.89
+	Hs
		432338 HS90A_HUMAN (1-732): 0: 1087: 100.00		FKBPL_HUMAN (133-414): 4.04e-51: 178: 25.70
+	Hs
		111929 K9JA46_HUMAN (1-732): 0: 1087: 100.00		AIP_HUMAN (144-414): 1.52e-49: 173: 16.72
+	Hs
		118674 HS90A_HUMAN (1-732): 0: 1087: 100.00		AIP_HUMAN (144-414): 1.52e-49: 173: 16.72
+	Hs
		118678 HS90B_HUMAN (19-732): 0: 1059: 86.13		AIP_HUMAN (144-414): 1.52e-49: 173: 16.72
+	Hs
		111930 K9JA46_HUMAN (1-732): 0: 1087: 100.00		FKBP6_HUMAN (2-137): 2.27e-35: 135: 35.97
+	Hs
		259914 HS90A_HUMAN (1-732): 0: 1087: 100.00		FKBP6_HUMAN (2-137): 2.27e-35: 135: 35.97
+	Hs
		431850 HS90A_HUMAN (1-732): 0: 1087: 100.00		FKBP8_HUMAN (25-330): 3.36e-27: 114: 19.23
+	Hs
		259915 HS90B_HUMAN (19-732): 0: 1059: 86.13		FKBP6_HUMAN (2-137): 2.27e-35: 135: 35.97
+	Hs
		111934 K9JA46_HUMAN (1-732): 0: 1087: 100.00		STIP1_HUMAN (265-457): 3.91e-23: 104: 17.62
+	Hs
		431574 HS90A_HUMAN (1-732): 0: 1087: 100.00		STIP1_HUMAN (265-457): 3.91e-23: 104: 17.62
+	Hs
		431721 HS90A_HUMAN (1-732): 0: 1087: 100.00		FKB1A_HUMAN (151-247): 2.87e-21: 90.3: 26.73
+	Hs
		437930 HS90B_HUMAN (19-732): 0: 1059: 86.13		STIP1_HUMAN (265-457): 3.91e-23: 104: 17.62