Protein: ITB3
Integrin beta-3 (Platelet membrane glycoprotein IIIa) (GPIIIa) (CD antigen CD61)

Gene: ITB3, ITGB3
Organism: Homo sapiens
Interactions: 71
UniProt ID: P05106

Gene Ontology (top 5):
GO:0001618 - virus receptor activity
GO:0001938 - positive regulation of endothelial cell proliferation
GO:0001954 - positive regulation of cell-matrix adhesion
GO:0001968 - fibronectin binding
GO:0002020 - protease binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

423998

ITA2B
Integrin alpha-IIb

16

20

Small-scale

0.987

High

423993

ITAV
Integrin alpha-V

9

20

Small-scale

0.969

High

424047

TLN1
Talin-1

6

20

Small-scale

0.946

High

423990

ITB3
Integrin beta-3

3

12

Small-scale

0.843

High

424010

FLNA
Filamin-A

2

20

Small-scale

0.793

High

388883

FINC
Fibronectin

2

13

Small-scale

0.768

High

407745

VWF
von Willebrand factor

2

3

Small-scale

0.768

High

423999

ITA5
Integrin alpha-5

2

20

Small-scale

0.768

High

424011

PTPRZ
Receptor-type tyrosine-protein phosphatase zeta

2

10

Small-scale

0.754

High

424041

DOK1
Docking protein 1

1

4

Small-scale

0.647

High

424026

FAK1
Focal adhesion kinase 1

3

20

Small-scale

0.646

High

387936

FIBG
Fibrinogen gamma chain

3

6

Small-scale

0.631

High

424005

PA2GA
Phospholipase A2, membrane associated

2

1

Small-scale

0.629

High

277992

FLNB
Filamin-B

1

20

Small-scale

0.621

High

424004

CEAM1
Cell adhesion molecule CEACAM1

1

10

Small-scale

0.618

High

424013

EPHA2
Ephrin type-A receptor 2

1

18

Small-scale

0.618

High

424018

MUC18
Cell surface glycoprotein MUC18

1

10

High-throughput

0.618

High

424031

ADA15
Disintegrin and metalloproteinase domain-containing protein 15

1

17

Small-scale

0.618

High

424024

X3CL1
Fractalkine

2

4

Small-scale

0.612

High

424029

CENPR
Centromere protein R

2

1

Small-scale

0.609

High

423996

TSP1
Thrombospondin-1

2

13

Small-scale

0.595

High

424025

CO4A3
Collagen alpha-3(IV) chain

2

3

Small-scale

0.584

High

424014

SHC1
SHC-transforming protein 1

2

14

Small-scale

0.563

High

421286

A4
Amyloid-beta precursor protein

1

4

Small-scale

0.561

High

424017

GRIA2
Glutamate receptor 2

1

2

Small-scale

0.561

High

424020

PA24A
Cytosolic phospholipase A2

1

8

Small-scale

0.561

High

424008

PTN1
Tyrosine-protein phosphatase non-receptor type 1

1

14

Small-scale

0.536

High

168029

RGS12
Regulator of G-protein signaling 12

1

1

Small-scale

0.501

High

374336

RASH
GTPase HRas

1

16

Small-scale

0.501

High

423994

PDIA1
Protein disulfide-isomerase

1

8

Small-scale

0.501

High

424002

FGFR1
Fibroblast growth factor receptor 1

1

20

Small-scale

0.501

High

424003

SRC
Proto-oncogene tyrosine-protein kinase Src

1

14

Small-scale

0.501

High

424012

MK03
Mitogen-activated protein kinase 3

1

2

Small-scale

0.501

High

424015

AKT1
RAC-alpha serine/threonine-protein kinase

1

12

Small-scale

0.501

High

424022

PAXI
Paxillin

1

20

Small-scale

0.501

High

424028

EPS8
Epidermal growth factor receptor kinase substrate 8

1

7

Small-scale

0.501

High

424032

FAK2
Protein-tyrosine kinase 2-beta

1

20

Small-scale

0.501

High

424037

TENS2
Tensin-2

1

5

Small-scale

0.501

High

424038

ANS1B
Ankyrin repeat and sterile alpha motif domain-containing protein 1B

1

7

Small-scale

0.501

High

424045

JIP1
C-Jun-amino-terminal kinase-interacting protein 1

1

11

Small-scale

0.501

High

423992

CDK1
Cyclin-dependent kinase 1

1

0

Small-scale

0.480

High

354495

PAK4
Serine/threonine-protein kinase PAK 4

1

4

Small-scale

0.479

High

399522

VTNC
Vitronectin

1

4

Small-scale

0.479

High

400102

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

4

High-throughput

0.479

High

423991

KPCB
Protein kinase C beta type

1

13

Small-scale

0.479

High

423995

LYN
Tyrosine-protein kinase Lyn

1

14

Small-scale

0.479

High

423997

MMP2
72 kDa type IV collagenase

1

14

Small-scale

0.479

High

424001

PGFRB
Platelet-derived growth factor receptor beta

1

14

Small-scale

0.479

High

424006

PGFRA
Platelet-derived growth factor receptor alpha

1

14

Small-scale

0.479

High

424007

CD36
Platelet glycoprotein 4

1

2

Small-scale

0.479

High

424009

PTN
Pleiotrophin

1

1

Small-scale

0.479

High

424016

VGFR2
Vascular endothelial growth factor receptor 2

1

12

Small-scale

0.479

High

424019

KSYK
Tyrosine-protein kinase SYK

1

20

Small-scale

0.479

High

424021

TISD
mRNA decay activator protein ZFP36L2

1

1

High-throughput

0.479

High

424030

ILK
Scaffold protein ILK

1

6

Small-scale

0.479

High

424033

CASL
Enhancer of filamentation 1

1

1

Small-scale

0.479

High

424039

URP2
Fermitin family homolog 3

1

17

Small-scale

0.479

High

424040

ITCH
E3 ubiquitin-protein ligase Itchy homolog

1

8

Small-scale

0.479

High

424000

VIME
Vimentin

1

0

Small-scale

0.458

High

424042

CIB1
Calcium and integrin-binding protein 1

1

0

Small-scale

0.458

High

424044

GULP1
PTB domain-containing engulfment adapter protein 1

1

12

Small-scale

0.457

High

424046

RBGP1
Rab GTPase-activating protein 1

1

5

Small-scale

0.457

High

424023

CX3C1
CX3C chemokine receptor 1

1

1

Small-scale

0.445

High

424027

PTN11
Tyrosine-protein phosphatase non-receptor type 11

1

10

Small-scale

0.445

High

424035

MICB
MHC class I polypeptide-related sequence B

1

2

High-throughput

0.445

High

424043

B3GN2
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2

1

4

High-throughput

0.437

High

387684

FIBA
Fibrinogen alpha chain [Cleaved into: Fibrinopeptide A; Fibrinogen alpha chain]

1

6

Small-scale

0.408

High

424036

MIIP
Migration and invasion-inhibitory protein

1

0

Small-scale

0.292

High

378351

IFNB
Interferon beta

1

0

Small-scale

0.261

Low

424034

PDK1
[Pyruvate dehydrogenase

1

0

Small-scale

0.261

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025