HitPredict

Interactor 1: HS90A (P07900)
Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86) (Heat shock protein family C member 1) (Lipopolysaccharide-associated protein 2) (LAP-2) (LPS-associated protein 2) (Renal carcinoma antigen NY-REN-38)
Gene: HSP90AA1

Interactor 2: SIM2 (Q14190)
Single-minded homolog 2 (Class E basic helix-loop-helix protein 15) (bHLHe15)
Gene: SIM2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	22939624
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 732 Hs			1 667
+	Hs
		438165 HS90B_HUMAN (19-732): 0: 1059: 86.13		SIM2_HUMAN (1-667): 0: 541: 100.00
+	Hs
		431737 HS90A_HUMAN (1-732): 0: 1087: 100.00		SIM1_HUMAN (1-663): 2.16e-160: 481: 55.31
+	Mm
		432429 HS90A_MOUSE (1-732): 0: 1083: 97.82		SIM1_MOUSE (1-663): 4.14e-158: 476: 54.73
+	Hs
		432201 HS90A_HUMAN (1-732): 0: 1087: 100.00		EPAS1_HUMAN (2-667): 1.56e-133: 415: 23.86
+	Mm
		432431 HS90A_MOUSE (1-732): 0: 1083: 97.82		HIF1A_MOUSE (2-525): 3.97e-129: 403: 31.11
+	Hs
		431903 HS90A_HUMAN (1-732): 0: 1087: 100.00		HIF1A_HUMAN (2-501): 2.75e-126: 395: 32.11
+	Hs
		438217 HS90B_HUMAN (19-732): 0: 1059: 86.13		HIF1A_HUMAN (2-501): 2.75e-126: 395: 32.11
+	Hs
		126097 HS90A_HUMAN (1-732): 0: 1087: 100.00		BMAL1_HUMAN (2-496): 1.25e-113: 356: 21.11
+	Hs
		432385 HS90A_HUMAN (1-732): 0: 1087: 100.00		HIF3A_HUMAN (2-660): 8.43e-109: 345: 26.19
+	Hs
		431556 HS90A_HUMAN (1-732): 0: 1087: 100.00		ARNT_HUMAN (2-576): 5.63e-105: 338: 16.72
+	Hs
		431594 HS90A_HUMAN (1-732): 0: 1087: 100.00		AHR_HUMAN (5-518): 5.16e-91: 303: 20.04
+	Mm
		432410 HS90A_MOUSE (1-732): 0: 1083: 97.82		AHR_MOUSE (5-517): 6.18e-92: 305: 22.65
+	Rn
		783943 HS90A_RAT (1-732): 0: 1085: 97.95		AHR_RAT (5-518): 3.38e-91: 303: 22.81
+	Hs
		438468 HS90B_HUMAN (19-732): 0: 1059: 86.13		NPAS1_HUMAN (2-494): 3.68e-101: 322: 31.60
+	Hs
		432199 HS90A_HUMAN (1-732): 0: 1087: 100.00		NPAS2_HUMAN (2-651): 1.41e-86: 290: 17.06
+	Mm
		513659 HS90B_MOUSE (19-732): 0: 1063: 86.98		AHR_MOUSE (5-517): 6.18e-92: 305: 22.65
+	Dm
		1096504 Q9VAY2_DROME (15-700): 0: 537: 46.13		SIMA_DROME (2-665): 6.85e-96: 325: 23.04