HitPredict

Interactor 1: HS90A (P07900)
Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86) (Heat shock protein family C member 1) (Lipopolysaccharide-associated protein 2) (LAP-2) (LPS-associated protein 2) (Renal carcinoma antigen NY-REN-38)
Gene: HSP90AA1

Interactor 2: U5S1 (Q15029)
116 kDa U5 small nuclear ribonucleoprotein component (Elongation factor Tu GTP-binding domain-containing protein 2) (SNU114 homolog) (hSNU114) (U5 snRNP-specific protein, 116 kDa) (U5-116 kDa)
Gene: EFTUD2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	28515276, 19875381
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003723 - RNA binding GO:0005525 - GTP binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol and 2 others more... GO:0016020 - membrane GO:0042220 - response to cocaine
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 732 Hs			1 972
+	Hs
		438180 HS90B_HUMAN (19-732): 0: 1059: 86.13		U5S1_HUMAN (1-972): 0: 1062: 100.00
+	Hs
		431483 HS90A_HUMAN (1-732): 0: 1087: 100.00		EF2_HUMAN (111-957): 0: 915: 38.16
+	Hs
		437850 HS90B_HUMAN (19-732): 0: 1059: 86.13		EF2_HUMAN (111-957): 0: 915: 38.16
+	Hs
		538238 ENPL_HUMAN (14-701): 0: 898: 46.78		U5S1_HUMAN (1-972): 0: 1062: 100.00
+	Ca
		804505 HSP90_CANAL (12-732): 0: 914: 60.50		EF2_CANAL (111-957): 0: 875: 36.04
+	Sc
		365955 HSP82_YEAST (16-732): 0: 907: 60.08		EF2_YEAST (111-957): 0: 879: 36.04
+	Sc
		543368 HSC82_YEAST (16-732): 0: 902: 59.39		EF2_YEAST (111-957): 0: 879: 36.04
+	Sc
		366111 HSP82_YEAST (16-732): 0: 907: 60.08		SN114_YEAST (3-967): 0: 692: 32.82