HitPredict

Interactor 1: HS90A (P07900)
Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86) (Heat shock protein family C member 1) (Lipopolysaccharide-associated protein 2) (LAP-2) (LPS-associated protein 2) (Renal carcinoma antigen NY-REN-38)
Gene: HSP90AA1

Interactor 2: STYK1 (Q6J9G0)
Tyrosine-protein kinase STYK1 (EC 2.7.10.2) (Novel oncogene with kinase domain) (Protein PK-unique) (Serine/threonine/tyrosine kinase 1)
Gene: STYK1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.72	0.60	0.660

Property	Details
Experiments	32707033, 35384245, 22939624
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 732 Hs			1 422
+	Hs
		431691 HS90A_HUMAN (1-732): 0: 1087: 100.00		EPHB1_HUMAN (5-417): 7.24e-127: 391: 19.38
+	Hs
		431472 HS90A_HUMAN (1-732): 0: 1087: 100.00		FGFR1_HUMAN (11-417): 2.76e-127: 388: 24.20
+	Hs
		431536 HS90A_HUMAN (1-732): 0: 1087: 100.00		FGFR3_HUMAN (10-409): 1.6e-125: 383: 27.01
+	Hs
		431562 HS90A_HUMAN (1-732): 0: 1087: 100.00		EPHA3_HUMAN (2-408): 7.62e-122: 378: 20.49
+	Hs
		431561 HS90A_HUMAN (1-732): 0: 1087: 100.00		EPHA2_HUMAN (46-411): 2.25e-121: 377: 21.95
+	Hs
		431435 HS90A_HUMAN (1-732): 0: 1087: 100.00		RET_HUMAN (8-415): 2.01e-119: 375: 23.29
+	Hs
		431692 HS90A_HUMAN (1-732): 0: 1087: 100.00		EPHA4_HUMAN (42-417): 8.52e-119: 370: 18.73
+	Hs
		169159 HS90A_HUMAN (1-732): 0: 1087: 100.00		MUSK_HUMAN (24-393): 4.95e-119: 368: 22.28
+	Hs
		431534 HS90A_HUMAN (1-732): 0: 1087: 100.00		FGFR4_HUMAN (80-392): 2.13e-119: 367: 28.79
+	Hs
		169160 HS90B_HUMAN (19-732): 0: 1059: 86.13		MUSK_HUMAN (24-393): 4.95e-119: 368: 22.28
+	Hs
		431481 HS90A_HUMAN (1-732): 0: 1087: 100.00		SRC_HUMAN (90-390): 1.63e-110: 336: 28.95
+	Hs
		411945 HS90A_HUMAN (1-732): 0: 1087: 100.00		FYN_HUMAN (92-390): 1.01e-109: 334: 28.33
+	Hs
		431627 HS90A_HUMAN (1-732): 0: 1087: 100.00		FRK_HUMAN (83-386): 1.13e-109: 333: 28.25
+	Hs
		431433 HS90A_HUMAN (1-732): 0: 1087: 100.00		YES_HUMAN (88-390): 1.93e-108: 331: 28.76
+	Hs
		337312 HS90A_HUMAN (1-732): 0: 1087: 100.00		ABL1_HUMAN (143-387): 8.6e-41: 156: 35.34
+	Hs
		431626 HS90A_HUMAN (1-732): 0: 1087: 100.00		ABL2_HUMAN (143-381): 3.74e-40: 155: 36.63
+	Hs
		431591 HS90A_HUMAN (1-732): 0: 1087: 100.00		TIE1_HUMAN (120-380): 8.51e-36: 142: 32.96
+	Hs
		431619 HS90A_HUMAN (1-732): 0: 1087: 100.00		CSK_HUMAN (144-386): 2.31e-36: 140: 36.89
+	Hs
		337314 HS90B_HUMAN (19-732): 0: 1059: 86.13		ABL1_HUMAN (143-387): 8.6e-41: 156: 35.34
+	Hs
		69196 HS90B_HUMAN (19-732): 0: 1059: 86.13		A9UEZ6_HUMAN (143-387): 1.01e-40: 156: 35.34