HitPredict

Interactor 1: HS90A (P07900)
Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86) (Heat shock protein family C member 1) (Lipopolysaccharide-associated protein 2) (LAP-2) (LPS-associated protein 2) (Renal carcinoma antigen NY-REN-38)
Gene: HSP90AA1

Interactor 2: M3K14 (Q99558)
Mitogen-activated protein kinase kinase kinase 14 (EC 2.7.11.25) (NF-kappa-beta-inducing kinase) (HsNIK) (Serine/threonine-protein kinase NIK)
Gene: MAP3K14

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.91	1.00	0.958

Property	Details
Experiments	30833792, 31980649, 32707033, 17563756, 22939624, 14743216, unassigned2173
Identification Methods	affinity chromatography technology, tandem affinity purification, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	HSP90~Pkinase
Common GO terms	GO:0005524 - ATP binding GO:0005654 - nucleoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 732 Hs			1 947
+	Hs
		431573 HS90A_HUMAN (1-732): 0: 1087: 100.00		AKT2_HUMAN (286-701): 1.96e-133: 411: 20.32
+	Hs
		432376 HS90A_HUMAN (1-732): 0: 1087: 100.00		AKT3_HUMAN (272-705): 8.39e-132: 406: 19.01
+	Hs
		431572 HS90A_HUMAN (1-732): 0: 1087: 100.00		AKT1_HUMAN (286-713): 3.76e-131: 405: 19.33
+	Rn
		812703 HS90A_RAT (1-732): 0: 1085: 97.95		AKT1_RAT (286-713): 2.82e-131: 405: 19.33
+	Hs
		432286 HS90A_HUMAN (1-732): 0: 1087: 100.00		PAK6_HUMAN (70-672): 1.33e-125: 397: 17.46
+	Hs
		431800 HS90A_HUMAN (1-732): 0: 1087: 100.00		AAPK1_HUMAN (374-909): 2.62e-124: 390: 17.48
+	Hs
		431542 HS90A_HUMAN (1-732): 0: 1087: 100.00		KS6B1_HUMAN (341-818): 1.79e-124: 389: 18.20
+	Rn
		871252 HS90A_RAT (1-732): 0: 1085: 97.95		AAPK1_RAT (374-909): 5.75e-123: 386: 17.30
+	Hs
		431511 HS90A_HUMAN (1-732): 0: 1087: 100.00		KAPCA_HUMAN (361-691): 1.53e-122: 378: 20.46
+	Hs
		116956 HS90A_HUMAN (1-732): 0: 1087: 100.00		SGK1_HUMAN (354-729): 7.08e-116: 363: 21.19
+	Hs
		432294 HS90A_HUMAN (1-732): 0: 1087: 100.00		STK36_HUMAN (406-773): 1.77e-98: 338: 26.50
+	Hs
		431672 HS90A_HUMAN (1-732): 0: 1087: 100.00		KS6A3_HUMAN (319-656): 2.54e-97: 324: 20.46
+	Hs
		431873 HS90A_HUMAN (1-732): 0: 1087: 100.00		KS6A2_HUMAN (319-657): 9e-97: 322: 21.49
+	Hs
		431792 HS90A_HUMAN (1-732): 0: 1087: 100.00		STK4_HUMAN (405-650): 2.6e-99: 321: 30.80
+	Hs
		431876 HS90A_HUMAN (1-732): 0: 1087: 100.00		KS6A1_HUMAN (319-695): 1.9e-95: 318: 18.21
+	Hs
		432343 HS90A_HUMAN (1-732): 0: 1087: 100.00		KS6A6_HUMAN (305-712): 2.32e-93: 313: 17.70
+	Hs
		431620 HS90A_HUMAN (1-732): 0: 1087: 100.00		M3K8_HUMAN (379-647): 2.68e-29: 124: 30.66
+	Hs
		431808 HS90A_HUMAN (1-732): 0: 1087: 100.00		M3K1_HUMAN (370-643): 2.05e-24: 112: 30.52
+	Hs
		432386 HS90A_HUMAN (1-732): 0: 1087: 100.00		M3K2_HUMAN (386-626): 1.28e-24: 112: 33.60
+	Hs
		432200 HS90A_HUMAN (1-732): 0: 1087: 100.00		M3K3_HUMAN (373-612): 7.37e-23: 106: 32.14