HitPredict

Interactor 1: HS90A (P07900)
Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86) (Heat shock protein family C member 1) (Lipopolysaccharide-associated protein 2) (LAP-2) (LPS-associated protein 2) (Renal carcinoma antigen NY-REN-38)
Gene: HSP90AA1

Interactor 2: UN45A (Q9H3U1)
Protein unc-45 homolog A (Unc-45A) (GCUNC-45) (Smooth muscle cell-associated protein 1) (SMAP-1)
Gene: UNC45A

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.72	1.00	0.854

Property	Details
Experiments	18285346, 27888470, 19875381
Identification Methods	pull down, two hybrid, affinity chromatography technology, tandem affinity purification
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	HSP90~TPR_8
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0048471 - perinuclear region of cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 732 Hs			1 944
+	Hs
		111940 K9JA46_HUMAN (1-732): 0: 1087: 100.00		UN45B_HUMAN (20-939): 0: 905: 56.70
+	Hs
		432038 HS90A_HUMAN (1-732): 0: 1087: 100.00		UN45B_HUMAN (20-939): 0: 905: 56.70
+	Hs
		432268 HS90A_HUMAN (1-732): 0: 1087: 100.00		RPAP3_HUMAN (15-343): 5.32e-41: 163: 17.06
+	Hs
		111935 K9JA46_HUMAN (1-732): 0: 1087: 100.00		PPP5_HUMAN (10-180): 3.77e-39: 154: 23.98
+	Hs
		431681 HS90A_HUMAN (1-732): 0: 1087: 100.00		PPP5_HUMAN (10-180): 3.77e-39: 154: 23.98
+	Hs
		432194 HS90A_HUMAN (1-732): 0: 1087: 100.00		TTC1_HUMAN (11-172): 2.98e-40: 152: 28.49
+	Mm
		432427 HS90A_MOUSE (1-732): 0: 1083: 97.82		PPP5_MOUSE (10-180): 2.35e-39: 155: 23.98
+	Hs
		213451 HS90A_HUMAN (1-732): 0: 1087: 100.00		SGTA_HUMAN (1-141): 4.45e-39: 149: 27.66
+	Hs
		432363 HS90A_HUMAN (1-732): 0: 1087: 100.00		CHIP_HUMAN (8-159): 1.54e-35: 139: 29.30
+	Mm
		513680 HS90B_MOUSE (19-732): 0: 1063: 86.98		PPP5_MOUSE (10-180): 2.35e-39: 155: 23.98
+	Hs
		431886 HS90A_HUMAN (1-732): 0: 1087: 100.00		TOM34_HUMAN (2-139): 4.73e-31: 126: 27.54
+	Hs
		431774 HS90A_HUMAN (1-732): 0: 1087: 100.00		SPAG1_HUMAN (16-201): 1.08e-25: 116: 22.61
+	Mm
		513709 HS90B_MOUSE (19-732): 0: 1063: 86.98		CHIP_MOUSE (17-159): 3.41e-35: 138: 29.05
+	Hs
		174556 HS90A_HUMAN (1-732): 0: 1087: 100.00		OGT1_HUMAN (3-192): 2.53e-24: 112: 12.63
+	Hs
		111934 K9JA46_HUMAN (1-732): 0: 1087: 100.00		STIP1_HUMAN (4-228): 9.18e-17: 86.8: 15.32
+	Hs
		431574 HS90A_HUMAN (1-732): 0: 1087: 100.00		STIP1_HUMAN (4-228): 9.18e-17: 86.8: 15.32
+	Hs
		432331 HS90A_HUMAN (1-732): 0: 1087: 100.00		Z3H7B_HUMAN (21-143): 1.06e-11: 71.2: 33.33
+	Hs
		111943 K9JA46_HUMAN (1-732): 0: 1087: 100.00		FKBPL_HUMAN (25-135): 1.26e-11: 69.3: 37.93
+	Hs
		432338 HS90A_HUMAN (1-732): 0: 1087: 100.00		FKBPL_HUMAN (25-135): 1.26e-11: 69.3: 37.93
+	Hs
		297024 HS90A_HUMAN (1-732): 0: 1087: 100.00		TOM70_HUMAN (12-220): 4.6e-09: 62.2: 13.08