Protein: RHG12
Rho GTPase-activating protein 12 (Rho-type GTPase-activating protein 12)

Gene: RHG12, ARHGAP12
Organism: Homo sapiens
Interactions: 68
UniProt ID: Q8IWW6

Gene Ontology (top 5):
GO:0001891 - phagocytic cup
GO:0002011 - morphogenesis of an epithelial sheet
GO:0005096 - GTPase activator activity
GO:0005737 - cytoplasm
GO:0005886 - plasma membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1311220

ZO2
Tight junction protein 2

5

7

High-throughput

0.908

High

1311223

ASAP1
Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1

4

13

High-throughput

0.875

High

1150873

CIP4
Cdc42-interacting protein 4

3

14

High-throughput

0.845

High

207927

ASAP2
Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2

3

13

High-throughput

0.839

High

952941

ACTB
Actin, cytoplasmic 1

3

19

High-throughput

0.839

High

1311227

SHAN2
SH3 and multiple ankyrin repeat domains protein 2

2

10

High-throughput

0.783

High

987756

GRB2
Growth factor receptor-bound protein 2

2

20

High-throughput

0.754

High

631332

RAB5A
Ras-related protein Rab-5A

2

1

High-throughput

0.737

High

1006528

SRPK2
SRSF protein kinase 2

1

10

High-throughput

0.710

High

1311213

SRPK1
SRSF protein kinase 1

1

7

High-throughput

0.710

High

885832

KC1E
Casein kinase I isoform epsilon

1

16

High-throughput

0.691

High

993235

ACTG
Actin, cytoplasmic 2

1

19

High-throughput

0.691

High

1153373

MK11
Mitogen-activated protein kinase 11

1

7

High-throughput

0.691

High

1200995

ACTBL
Beta-actin-like protein 2

1

19

High-throughput

0.691

High

1258031

RAPH1
Ras-associated and pleckstrin homology domains-containing protein 1

1

5

High-throughput

0.691

High

1311214

SHAN3
SH3 and multiple ankyrin repeat domains protein 3

1

13

High-throughput

0.691

High

1311218

ABI2
Abl interactor 2

1

20

High-throughput

0.691

High

133670

WASL
Actin nucleation-promoting factor WASL

3

4

High-throughput

0.665

High

1272175

CYFP1
Cytoplasmic FMR1-interacting protein 1

3

4

High-throughput

0.650

High

988510

RAC1
Ras-related C3 botulinum toxin substrate 1

1

20

High-throughput

0.647

High

1311199

ABI1
Abl interactor 1

1

16

High-throughput

0.618

High

126687

RHOD
Rho-related GTP-binding protein RhoD

1

20

High-throughput

0.618

High

375700

RASK
GTPase KRas

1

15

High-throughput

0.618

High

463636

LYN
Tyrosine-protein kinase Lyn

1

15

High-throughput

0.618

High

945037

RAB25
Ras-related protein Rab-25

1

1

High-throughput

0.618

High

978145

RHOB
Rho-related GTP-binding protein RhoB

1

20

High-throughput

0.618

High

1311211

RHOV
Rho-related GTP-binding protein RhoV

1

20

High-throughput

0.618

High

1311215

RHOF
Rho-related GTP-binding protein RhoF

1

20

High-throughput

0.618

High

1311225

ALK
ALK tyrosine kinase receptor

1

20

High-throughput

0.618

High

611217

PTN1
Tyrosine-protein phosphatase non-receptor type 1

2

8

High-throughput

0.611

High

1311200

FNBP4
Formin-binding protein 4

1

0

High-throughput

0.578

High

977748

ACTA
Actin, aortic smooth muscle

1

18

High-throughput

0.575

High

1311198

PHAR4
Phosphatase and actin regulator 4

1

1

High-throughput

0.536

High

1311206

PALLD
Palladin

1

5

High-throughput

0.536

High

1311207

WASF1
Actin-binding protein WASF1

1

5

High-throughput

0.536

High

1311209

CYFP2
Cytoplasmic FMR1-interacting protein 2

1

4

High-throughput

0.536

High

1311216

MUC5B
Mucin-5B

1

3

High-throughput

0.536

High

1311217

JPH1
Junctophilin-1

1

4

High-throughput

0.536

High

1311222

DMBT1
Scavenger receptor cysteine-rich domain-containing protein DMBT1

1

4

High-throughput

0.536

High

1311226

SUFU
Suppressor of fused homolog

1

1

High-throughput

0.536

High

1311228

WASF3
Actin-binding protein WASF3

1

2

High-throughput

0.536

High

1311229

NCKP1
Nck-associated protein 1

1

1

High-throughput

0.536

High

1150759

SF01
Splicing factor 1

2

2

High-throughput

0.521

High

1311204

BRK1
Protein BRICK1

1

0

High-throughput

0.513

High

888636

YLPM1
YLP motif-containing protein 1

1

5

High-throughput

0.489

High

1311205

RN138
E3 ubiquitin-protein ligase RNF138

1

1

High-throughput

0.489

High

1311219

NHSL3
NHS-like protein 3

1

7

High-throughput

0.489

High

1311224

PRR12
Proline-rich protein 12

1

4

High-throughput

0.489

High

1311231

WASF2
Actin-binding protein WASF2

1

3

High-throughput

0.489

High

173037

XPO1
Exportin-1

1

15

High-throughput

0.479

High

431182

LA
Lupus La protein

1

4

High-throughput

0.479

High

642961

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

7

High-throughput

0.479

High

1254542

TRI67
Tripartite motif-containing protein 67

1

20

High-throughput

0.479

High

1288718

KTN1
Kinectin

1

8

High-throughput

0.479

High

1311201

BICD2
Protein bicaudal D homolog 2

1

11

High-throughput

0.479

High

1311221

ZRAN1
Ubiquitin thioesterase ZRANB1

1

8

High-throughput

0.479

High

1311212

MAGBA
Melanoma-associated antigen B10

1

4

High-throughput

0.470

High

379668

IGHA1
Immunoglobulin heavy constant alpha 1

1

5

High-throughput

0.445

High

530052

TAU
Microtubule-associated protein tau

1

8

High-throughput

0.445

High

537472

HSP7C
Heat shock cognate 71 kDa protein

1

2

High-throughput

0.445

High

106235

APRIO
Alternative prion protein

1

8

High-throughput

0.437

High

973761

RUXE
Small nuclear ribonucleoprotein E

1

1

High-throughput

0.437

High

1311203

PPIL4
Peptidyl-prolyl cis-trans isomerase-like 4

1

4

High-throughput

0.437

High

1311208

ESR2
Estrogen receptor beta

1

11

High-throughput

0.437

High

1311210

BICD1
Protein bicaudal D homolog 1

1

9

High-throughput

0.437

High

1311230

NOC2L
Nucleolar complex protein 2 homolog

1

1

High-throughput

0.437

High

1311202

BPIB1
BPI fold-containing family B member 1

1

0

High-throughput

0.279

Low

1229554

VIR
Protein virilizer homolog

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025