HitPredict

Interactor 1: HS90A (P07900)
Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86) (Heat shock protein family C member 1) (Lipopolysaccharide-associated protein 2) (LAP-2) (LPS-associated protein 2) (Renal carcinoma antigen NY-REN-38)
Gene: HSP90AA1

Interactor 2: Q9H4D1 (Q9H4D1)
Protein kinase
Gene: dik

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	1.00	0.827

Property	Details
Experiments	26972000, 29435596, 33961781
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	HSP90~Pkinase
Common GO terms	GO:0005524 - ATP binding GO:0005737 - cytoplasm
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 732 Hs			1 784
+	Hs
		432186 HS90A_HUMAN (1-732): 0: 1087: 100.00		Q96T11_HUMAN (1-784): 0: 705: 99.49
+	Hs
		431704 HS90A_HUMAN (1-732): 0: 1087: 100.00		RIPK4_HUMAN (1-784): 0: 693: 93.99
+	Hs
		438529 HS90B_HUMAN (19-732): 0: 1059: 86.13		Q9H4D1_HUMAN (1-784): 0: 712: 100.00
+	Hs
		538399 ENPL_HUMAN (14-701): 0: 898: 46.78		Q9H4D1_HUMAN (1-784): 0: 712: 100.00
+	Hs
		538174 ENPL_HUMAN (14-701): 0: 898: 46.78		RIPK4_HUMAN (1-784): 0: 693: 93.99
+	Hs
		431682 HS90A_HUMAN (1-732): 0: 1087: 100.00		DAPK1_HUMAN (464-783): 4.07e-81: 286: 25.39
+	Hs
		438082 HS90B_HUMAN (19-732): 0: 1059: 86.13		ANK2_HUMAN (328-623): 7.99e-64: 235: 23.57
+	Hs
		201744 HS90A_HUMAN (1-732): 0: 1087: 100.00		RIPK2_HUMAN (31-284): 2.18e-54: 198: 44.36
+	Hs
		432073 HS90A_HUMAN (1-732): 0: 1087: 100.00		ANKK1_HUMAN (333-607): 8.82e-45: 174: 22.10
+	Hs
		438117 HS90B_HUMAN (19-732): 0: 1059: 86.13		ANK3_HUMAN (611-784): 2.5e-46: 182: 32.57
+	Hs
		438365 HS90B_HUMAN (19-732): 0: 1059: 86.13		ANKK1_HUMAN (333-607): 8.82e-45: 174: 22.10
+	Hs
		432396 HS90A_HUMAN (1-732): 0: 1087: 100.00		RIPK3_HUMAN (21-286): 1.6e-35: 143: 35.74
+	Hs
		438651 HS90B_HUMAN (19-732): 0: 1059: 86.13		RIPK3_HUMAN (21-286): 1.6e-35: 143: 35.74
+	Hs
		1123425 H90B4_HUMAN (30-604): 0: 571: 62.61		ANKK1_HUMAN (333-607): 8.82e-45: 174: 22.10